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Most Downloaded Cell Regeneration Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Molecular switch model for cardiomyocyte proliferation

June 2019
Satwat Hashmi | H.R. Ahmad

This review deals with the human adult cardiomyocyte proliferation as a potential source for heart repair after injury. The mechanism to regain the proliferative capacity of adult cardiomyocytes is...

2. Use of large animal models to investigate Huntington's diseases

June 2019
Sen Yan | Shihua Li | Xiao-Jiang Li

Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment. There is no doubt that small animal models have...

3. Methods and applications of CRISPR/Cas system for genome editing in stem cells

December 2019
Guang Yang | Xingxu Huang

Genome editing technology holds great promise for genome manipulation and gene therapy. While widespread utilization, genome editing has been used to unravel the roles of specific genes in differentiation...

4. Retrograde monosynaptic tracing through an engineered human embryonic stem cell line reveals synaptic inputs from host neurons to grafted cells

June 2019
Qi Xing | Aiping Lin | Zhenghui Su | Chunhua Liu | Wenhao Huang | Wenjing Guo | Guangjin Pan | Yiping Guo | Xiaofen Zhong

Retrograde monosynaptic tracing with EnvA-pseudotyped rabies virus has been employed to identify the afferent and efferent connectivity of transplanted human embryonic stem (hES) cell-derived neurons...

5. Approaches for generation of anti-leukemia specific T cells

December 2018
Zhenyi Jin | Ling Xu | Yangqiu Li

As three decades ago, it was reported that adoptive T cell immunotherapy by infusion of autologous tumor infiltrating lymphocytes (TILs) mediated objective cancer regression in patients with metastatic...

6. Cardiac progenitor reprogramming for heart regeneration

September 2018
Behnam Ebrahimi

Myocardial infarction leads to the loss of a huge number of cardiomyocytes and the reparatory response to this phenomenon is scar tissue formation, which impairs heart function. Direct reprogramming...

7. Hematopoiesis and microenvironment in hematological malignancies

September 2018
Hui Cheng | Guohuan Sun | Tao Cheng

Adult hematopoietic stem cells (HSCs) and progenitors (HPCs) reside in the bone marrow, a highly orchestrated architecture. In the bone marrow, the process of how HSCs exert self-renewal and differentiation...

8. Research advances in erythrocyte regeneration sources and methods in vitro

December 2018
Shuming Sun | Yuanliang Peng | Jing Liu

Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells...

9. Illumination of neural development by in vivo clonal analysis

December 2018
Mingrui Xu | Jingjing Wang | Xize Guo | Tingting Li | Xia Kuang | Qing-Feng Wu

Single embryonic and adult neural stem cells (NSCs) are characterized by their self-renewal and differentiation potential. Lineage tracing via clonal analysis allows for specific labeling of a single...

10. Relaunching of Cell Regeneration

December 2019
Ye-Guang Chen | Ying Lou

11. Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art

Eleni Oberbauer | Carolin Steffenhagen | Christoph Wurzer | Christian Gabriel | Heinz Redl | Susanne Wolbank

In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous...

12. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming

June 2019
Zhiwei Luo | Xiaobing Qing | Christina Benda | Zhijian Huang | Meng Zhang | Yinghua Huang | Hui Zhang | Lulu Wang | Yiwei Lai | Carl Ward | Giacomo Volpe | Xiaofen Zhong | Baoming Qin | Qiang Zhuang | Miguel A. Esteban | Wenjuan Li

Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind...

13. Long non-coding RNAs in hematopoietic regulation

December 2018
Weiqian Li | Yue Ren | Yanmin Si | Fang Wang | Jia Yu

Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate...

14. Vascularization mediated by mesenchymal stem cells from bone marrow and adipose tissue: a comparison

Karoline Pill | Sandra Hofmann | Heinz Redl | Wolfgang Holnthoner

Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting...

15. Role of Oct4 in the early embryo development

Guangming Wu | Hans R Schöler

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs)...

16. A protocol for generating induced T cells by reprogramming B cells in vivo

September 2018
Qitong Weng | Fangxiao Hu | Mengyun Zhang | Yong Dong | Cui Lv | Ying Wang | Xiaofei Liu | Jinyong Wang

Obtaining T cells by reprogramming is one of the major goals in regenerative medicine. Here, we describe a protocol for generating functional T cells from Hoxb5-expressing pro/pre-B cells in vivo. This...

17. Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension

September 2018
Bo Wang | Dongwei Li | Jiekai Chen | Jing Liu | Duanqing Pei

The oncogene c-Jun plays a key role in development and cancer. Yet, its role in cell fate decision remains poorly understood at the molecular level. Here we report that c-Jun confers different fate...

18. Genomic and molecular control of cell type and cell type conversions

December 2017
Xiuling Fu | Fangfang He | Yuhao Li | Allahverdi Shahveranov | Andrew Paul Hutchins

Organisms are made of a limited number of cell types that combine to form higher order tissues and organs. Cell types have traditionally been defined by their morphologies or biological activity, yet...

19. Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency

Behnam Ebrahimi

Induced pluripotent stem cells are powerful tools for disease modeling, drug screening, and cell transplantation therapies. These cells can be generated directly from somatic cells by ectopic expression...

20. Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles

Frank Fontaine | Jeroen Overman | Mathias François

Much research on transcription factor biology and their genetic pathways has been undertaken over the last 30 years, especially in the field of developmental biology and cancer. Yet, very little is...

21. Efficient cleavage resolves PAM preferences of CRISPR-Cas in human cells

December 2019
Lianchao Tang | Fayu Yang | Xiaoxue He | Haihua Xie | Xiaoyu Liu | Junhao Fu | Haitao Xi | Xiaosheng Lu | Changbao Liu | Zongming Song | Jia Qu | Junzhao Zhao | Feng Gu

Clustered regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas) of bacterial adaptive immunity have been adopted as a powerful and versatile tool for manipulation of the...

22. Wnt/β-catenin signaling in heart regeneration

Gunes Ozhan | Gilbert Weidinger

The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can...

23. Stem cell therapy for amyotrophic lateral sclerosis

Zhijuan Mao | Suming Zhang | Hong Chen

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole,...

24. Defining synthetic surfaces for human pluripotent stem cell culture

Jack W Lambshead | Laurence Meagher | Carmel O'Brien | Andrew L Laslett

Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling...

25. Using mouse models to study function of transcriptional factors in T cell development

Peng Li | Yiren Xiao | Zhixin Liu | Pentao Liu

Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we...

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