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Recent Cell Regeneration Articles

Recently published articles from Cell Regeneration.

RNA-binding proteins in mouse male germline stem cells: a mammalian perspective

2016
Huayu Qi

Adult stem cells that reside in particular types of tissues are responsible for tissue homeostasis and regeneration. Cellular functions of adult stem cells are intricately related to the gene expression...

Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency

2016
Young Jin Lee | Suresh Ramakrishna | Himanshu Chauhan | Won Sun Park | Seok-Ho Hong | Kye-Seong Kim

Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional...

Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish

2016
Wuhong Pei | Sunny C. Huang | Lisha Xu | Kade Pettie | María Laura Ceci | Mario Sánchez | Miguel L. Allende | Shawn M. Burgess

We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose...

ETV2 expression increases the efficiency of primitive endothelial cell derivation from human embryonic stem cells

2015
Anne G Lindgren | Matthew B Veldman | Shuo Lin

Endothelial cells line the luminal surface of blood vessels and form a barrier between the blood and other tissues of the body. Ets variant 2 (ETV2) is transiently expressed in both zebrafish and mice...

Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles

2015
Frank Fontaine | Jeroen Overman | Mathias François

Much research on transcription factor biology and their genetic pathways has been undertaken over the last 30 years, especially in the field of developmental biology and cancer. Yet, very little is...

Wnt/β-catenin signaling in heart regeneration

2015
Gunes Ozhan | Gilbert Weidinger

The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can...

GATA2−/− human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment

2015
Ke Huang | Juan Du | Ning Ma | Jiajun Liu | Pengfei Wu | Xiaoya Dong | Minghui Meng | Wenqian Wang | Xin Chen | Xi Shi | Qianyu Chen | Zhongzhou Yang | Shubin Chen | Jian Zhang | Yuhang Li | Wei Li | Yi Zheng | Jinglei Cai | Peng Li | Xiaofang Sun | Jinyong Wang | Duanqing Pei | Guangjin Pan

Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple...

The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis

2015
S.T. Ngo | F.J. Steyn

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is characterized by the selective degeneration of upper motor neurons and lower spinal motor neurons, resulting in the...

Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art

2015
Eleni Oberbauer | Carolin Steffenhagen | Christoph Wurzer | Christian Gabriel | Heinz Redl | Susanne Wolbank

In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous...

Stem cell aging in adult progeria

2015
Hoi-Hung Cheung | Duanqing Pei | Wai-Yee Chan

Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration,...

Regulatory functions and pathological relevance of the MECP2 3′UTR in the central nervous system

2015
Heather McGowan | Zhiping P. Pang

Methyl-CpG-binding protein 2 (MeCP2), encoded by the gene MECP2, is a transcriptional regulator and chromatin-remodeling protein, which is ubiquitously expressed and plays an essential role in the development...

Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency

2015
Behnam Ebrahimi

Induced pluripotent stem cells are powerful tools for disease modeling, drug screening, and cell transplantation therapies. These cells can be generated directly from somatic cells by ectopic expression...

Vascularization mediated by mesenchymal stem cells from bone marrow and adipose tissue: a comparison

2015
Karoline Pill | Sandra Hofmann | Heinz Redl | Wolfgang Holnthoner

Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting...

Stem cell therapy for amyotrophic lateral sclerosis

2015
Zhijuan Mao | Suming Zhang | Hong Chen

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole,...

Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

2015
Songwei He | Yiping Guo | Yixin Zhang | Yuan Li | Chengqian Feng | Xiang Li | Lilong Lin | Lin Guo | Haitao Wang | Chunhua Liu | Yi Zheng | Chuanming Luo | Qiang Liu | Fuhui Wang | Hao Sun | Lining Liang | Lingyu Li | Huanxing Su | Jiekai Chen | Duanqing Pei | Hui Zheng

Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptional...

Characterization of a novel cell penetrating peptide derived from human Oct4

2014
Eva Harreither | Hanna A Rydberg | Helene L Åmand | Vaibhav Jadhav | Lukas Fliedl | Christina Benda | Miguel A Esteban | Duanqing Pei | Nicole Borth | Regina Grillari-Voglauer | Oliver Hommerding | Frank Edenhofer | Bengt Nordén | Johannes Grillari

Oct4 is a transcription factor that plays a major role for the preservation of the pluripotent state in embryonic stem cells as well as for efficient reprogramming of somatic cells to induced pluripotent...

Generation of knockout rabbits using transcription activator-like effector nucleases

2014
Yu Wang | Nana Fan | Jun Song | Juan Zhong | Xiaogang Guo | Weihua Tian | Quanjun Zhang | Fenggong Cui | Li Li | Philip N Newsome | Jon Frampton | Miguel A Esteban | Liangxue Lai

Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of...

Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

2014
Aline C Planello | Junfeng Ji | Vivek Sharma | Rajat Singhania | Faridah Mbabaali | Fabian Müller | Javier A Alfaro | Christoph Bock | Daniel D De Carvalho | Nizar N Batada

The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced...

glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data

2014
Andrew Paul Hutchins | Ralf Jauch | Mateusz Dyla | Diego Miranda-Saavedra

Genomic datasets and the tools to analyze them have proliferated at an astonishing rate. However, such tools are often poorly integrated with each other: each program typically produces its own custom...

OCT4: A penetrant pluripotency inducer

2014
Xuecong Wang | Ralf Jauch

Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches,...

A mitochondrial strategy for safeguarding the reprogrammed genome

2014
Alessandro Prigione | James Adjaye

Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports...

Role of Oct4 in the early embryo development

2014
Guangming Wu | Hans R Schöler

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs)...

Bioengineering of a human whole tooth: progress and challenge

2014
Yanding Zhang | YiPing Chen

A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component...

Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin

2014
Anne Limbourg | Sabine Schnabel | Vladimir J Lozanovski | L Christian Napp | Teng-Cheong Ha | Tobias Maetzig | Johann Bauersachs | Hassan Y Naim | Axel Schambach | Florian P Limbourg

The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations...

Generation of multi-gene knockout rabbits using the Cas9/gRNA system

2014
Quanmei Yan | Quanjun Zhang | Huaqiang Yang | Qingjian Zou | Chengcheng Tang | Nana Fan | Liangxue Lai

The prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) is a simple, robust and efficient technique for gene targeting in model organisms such as zebrafish,...

Production of transgenic pigs over-expressing the antiviral gene Mx1

2014
Quanmei Yan | Huaqiang Yang | Dongshan Yang | Bentian Zhao | Zhen Ouyang | Zhaoming Liu | Nana Fan | Hongsheng Ouyang | Weiwang Gu | Liangxue Lai

The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interesting candidate gene to improve disease resistance in farm animals. In this study, we report...

Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

2014
Kamesh Narasimhan | Kevin Micoine | Emmanuel Lacôte | Serge Thorimbert | Edwin Cheung | Bernold Hasenknopf | Ralf Jauch

SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However,...

Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells

2014
Mark Ahearne | Joanne Lysaght | Amy P Lynch

Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linage differentiation capabilities. While much work has been done to optimize the differentiation media,...

The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

2013
Thomas Hill | Olga Krougly | Enayat Nikoopour | Stacey Bellemore | Edwin Lee-Chan | Lynette A Fouser | David J Hill | Bhagirath Singh

In Type 1 diabetes, the insulin-producing β-cells within the pancreatic islets of Langerhans are destroyed. We showed previously that immunotherapy with Bacillus Calmette-Guerin (BCG) or complete Freund's...

Generation of functional organs from stem cells

2013
Yunying Liu | Ru Yang | Zuping He | Wei-Qiang Gao

We are now well entering the exciting era of stem cells. Potential stem cell therapy holds great promise for the treatment of many diseases such as stroke, traumatic brain injury, Alzheimer's disease,...

SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells

2013
Leilei Zhang | Dajiang Qin | Chunfang Hao | Xiaodong Shu | Duanqing Pei

Sorting nexins are a large family of proteins that are associated with various components of the endosome system and they play many roles in processes such as endocytosis, intracellular protein trafficking...

Cohesin complexes with a potential to link mammalian meiosis to cancer

2013
Alexander Strunnikov

Among multiple genes aberrantly activated in cancers, invariably, there is a group related to the capacity of cell to self-renewal. Some of these genes are related to the normal process of development,...

Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs

2013
Renli Ru | Yongchao Yao | Songlin Yu | Benpeng Yin | Wanwan Xu | Siting Zhao | Li Qin | Xiaoping Chen

Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have been successfully used to knock out endogenous genes in stem cell research. However, the deficiencies of...

Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells

2013
Jinglei Cai | Yanmei Zhang | Pengfei Liu | Shubin Chen | Xuan Wu | Yuhua Sun | Ang Li | Ke Huang | Rongping Luo | Lihui Wang | Ying Liu | Ting Zhou | Shicheng Wei | Guangjin Pan | Duanqing Pei

Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth regularly due to accidents or diseases. An ideal solution to this problem is to regenerate tooth with patients’ own...

Defining synthetic surfaces for human pluripotent stem cell culture

2013
Jack W Lambshead | Laurence Meagher | Carmel O'Brien | Andrew L Laslett

Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling...

Differentiation of human mesenchymal stem cell spheroids under microgravity conditions

2012
Wolfgang H Cerwinka | Starlette M Sharp | Barbara D Boyan | Haiyen E Zhau | Leland W K Chung | Clayton Yates

To develop and characterize a novel cell culture method for the generation of undifferentiated and differentiated human mesenchymal stem cell 3D structures, we utilized the RWV system with a gelatin-based...

Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells

2012
Curtis C Hughey | Maria P Alfaro | Darrell D Belke | Jeffery N Rottman | Pampee P Young | David H Wasserman | Jane Shearer

Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction. Despite this, ischemia-induced death of transplanted cells remains...

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

2012
Wenguang Yin | Dapeng Liu | Nian Liu | Liangliang Xu | Song Li | Shuo Lin | Xiaodong Shu | Duanqing Pei

Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the...

A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro

2012
Fiona C Lewis | Nicholas Bryan | John A Hunt

Human embryonic stem cells (hESCs) represent a tremendous resource for cell therapies and the study of human development; however to maintain their undifferentiated state in vitro they routinely require...

Pluripotency and its layers of complexity

2012
Jolene Ooi | Pentao Liu

Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating...

Progress and bottleneck in induced pluripotency

2012
Zhen-Ning Zhang | Yang Xu

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of individual patients...

Using mouse models to study function of transcriptional factors in T cell development

2012
Peng Li | Yiren Xiao | Zhixin Liu | Pentao Liu

Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we...

Return to the hematopoietic stem cell origin

2012
Igor M Samokhvalov

Studying embryonic hematopoiesis is complicated by diversity of its locations in the constantly changing anatomy and by the mobility of blood cell precursors. Embryonic hematopoietic progenitors are...

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