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Recent Frontiers in Laboratory Medicine Articles

Recently published articles from Frontiers in Laboratory Medicine.

Association of ATG16L1 genetic variant with Helicobacter pylori infection in Egyptian patients with chronic gastritis disease

Available online 11 September 2019
Aya Hamdy Abd-EL Aziz | Heba Mohamed Abdallah | Samah Mohamed Awad | Osama EL-Bahr | Ashraf Khalil | Gamal Youssef Abo Riaa

Helicobacter pylori infection remains a major risk for gastroduodenal inflammation and ulceration with capability to disrupt the defensive autophagy pathway in the gastric mucosal cell thus producing...

MicroRNA profiling of cerebrospinal fluid from patients with intracerebral haemorrhage

Available online 14 August 2019
Qinghai Shi | Di Ge | Qi Yang | Li Wang | Jianfeng Fu

Differential expression profiles of free microRNAs (miRNAs) in cerebrospinal fluid (CSF) from patients with intracerebral haemorrhage (ICH) and controls were analysed to identify miRNA markers associated...

Application of terahertz spectroscopy in biomolecule detection

Available online 6 June 2019
Liu Wei | Liu Yu | Huang Jiaoqi | Huang Guorong | Zhang Yang | Fu Weiling

Terahertz (THz = 1012 Hz) radiation has caused enormous widespread attention due to its use in biomedical sciences. The tremendous advances in THz instruments have made an impressive breakthrough in...

Study on the immunity protection of 14-3-3–MPLA–liposome vaccine against cystic echinococcosis in mice

Available online 24 May 2019
ZongJi Li | Shuqing Ding | Yuan Li

The study aims to investigate the protective immunity against Echinococcus granulosus in mice immunized with14-3-3–MPLA–liposome vaccine. ICR (Institute of Cancer Research) mice were subcutaneously...

Combined detection of erythrocyte and reticulocyte to improve screening efficiency of thalassaemia trait in pregnancy

September 2018
Yuwei Yang | Jiafu Feng | Bi Peng | Xiaohong Chen | Jun Ying | Tao Yang

Both iron deficiency anemia (IDA) and thalassaemia trait (TT) are indistinguishable in pregnancy. This study aimed to establish some new hematological indices based on erythrocyte and reticulocyte parameters...

Prognostic value of Bmi-1 oncoprotein expression in non-small cell lung cancer

September 2018
Dan Xiong | Yunlin Ye | Bohua Kuang | Hongmei Mo | Xiaoqing Xu | Qinquan Cai | Enyun Wang | Wensen Lu | Yanping Luo | Jiehong Wei | Xiuming Zhang

Background: In our prior study, Bmi-1 was elevated in non-small cell lung cancer (NSCLC) and took an important role in the early stage of progression. However, the clinical significance of Bmi-1 in...

Prevalence of hepatitis E virus infection among pregnant women in Zhenjiang, China

September 2018
Zhilian Rui | Lihua Jiang | Xiaochun Wang | Yan Yang | Ying Peng | Yu Ling | Wen Zhang | Xingli Fu | Chenglin Zhou | Shixing Yang | Quan Shen

Most hepatitis E virus (HEV) infections are mild or subclinical, however, the infections are characteristically associated with a high incidence of symptomatic presentation among pregnant women....

Using digital PCR to detect HER2 amplification in breast and gastric cancer patients

September 2018
Ruifeng Zhou | Peng Yuan | Lihua Zhang | Shuangye Shen | Zhaoliang Li | Yan Wang

HER2 amplification detection assays are widely used as companion diagnostic tools for Herceptin targeted therapy on Breast and Gastric cancer patients. Current tests approved for clinical use are in...

A digital PCR assay development to detect EGFR T790M mutation in NSCLC patients

September 2018
Ruifeng Zhou | Yiran Cai | Zhaoliang Li | Shuangye Shen | Mozhou Sha | Steven R. Head | Yan Wang

Epidermal growth factor receptor (EGFR) is a crucial factor in the development of non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitor (TKI) therapy requires a sensitive and accurate assay...

Laboratory diagnosis of antiphospholipid syndrome

September 2018
Chao Wang | Xiu-ru Guan

Antiphospholipid syndrome (APS) is an autoimmune disease with manifestations of recurrent thromboembolic events, unexplained miscarriage, and thrombocytopenia. Although the presence of one or more types...

A digital PCR based assay to detect all ALK fusion species

June 2018
Ruifeng Zhou | Yiran Cai | Shuangye Shen | Mozhou Sha | Zhaoliang Li | Steven R. Head | Yan Wang

Accurate detection of Anaplastic lymphoma kinase (ALK) fusion in lung cancer cells is essential to screen for patients suitable for targeted drug treatments such as crizotinib. ALK fusion involves multiple...

Factors related to postoperative prognosis of kidney transplant recipients: A retrospective analysis of 127 patients

June 2018
Yuanyuan Gao | Xue Yu | Xiao Feng | Ya Zhang

At present, kidney transplant recipients are more likely to suffer from postoperative infection, rejection, or accidental death than general population. This study aims to discuss whether or not certain...

Advances of lncRNA in autoimmune diseases

June 2018
Jiajian Wang | Feng Wei | Haizhou Zhou

Long non-coding RNA (lncRNA) is a newly identified non-coding RNA with various regulatory functions. Recent evidence has shown how lncRNA affect the disease development at different degrees. Studies...

Applications of cerebrospinal miRNA in the detection and treatment of acute CNS injury

June 2018
Qi Yang | Qinghai Shi | Jianfeng Fu

MicroRNAs (miRNAs) are short-chain 20–24-nucleotide RNAs that are produced and processed from endogenous non-coding RNA (sncRNA). They act as a bridge between DNA, mRNAs, and proteins, induce epigenetic...

Autophagy: A new target for the treatment of atherosclerosis

June 2018
Yan Sun | Xiu-ru Guan

Atherosclerosis remains one of the main causes of death in both developed and developing countries, leading to acute cardiovascular events and chronic injuries. Atherosclerosis is a multifactorial disease,...

Diagnostic performance of magnetic beads-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for esophageal squamous cell carcinoma: A meta-analysis

June 2018
Ting Zhang | Na-Na Wang | Zhao-Lian Lu | Xin-Yan Jing | Cheng-Jin Hu

This study aimed to assess the overall diagnostic accuracy of magnetic beads-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MB-based MALDI-TOF MS) in identifying...

A marine sponge Fascaplysinopsis sp. derived alkaloid fascaplysin inhibits the HepG2 hepatocellular carcinoma cell

June 2018
Seduraman Naveen kumar | Govindan Rajivgandhi | Govindan Ramachandran | Natesan Manoharan

Recently, marine sponge drug fascaplysin has been found to have the potential to overcome cancer, particularly those of hepatocellular carcinoma. In this study, the decreased cell viability of HepG2...

Synthesis of chitosan nanoparticles by TPP and their potential mosquito larvicidal application

June 2018
M. Anand | P. Sathyapriya | M. Maruthupandy | A. Hameedha Beevi

Nowadays chitosan nanoparticles (CS NPs) have been extensively considered for biomedical applications. The purpose of this paper is to summarize the results of larvicidal activities of extracted chitosan...

Association between Zinc transporter genes ZIP11 rs11077654 polymorphism with bladder cancer risk in Chinese Han Population

March 2018
Ding-wei Liu | Jiang-shui Yuan | Li Li | Xiao-chen Wang | Zong-liang Zhang | Wei-qing Song

To study the association between Zinc transporter genes ZIP11 rs11077654 polymorphism with bladder cancer risk in Chinese Han Population....

Research progress on anti-mullerian hormone clinical applications and immunoassay development

March 2018
Hui Sun | Huajie Mao | Jianhui Cai | Ya Zhao

Anti-mullerian hormone (AMH) is a member of the transforming growth factor-β (TGF-β) superfamily and is also known as mullerian inhibiting substance (MIS) due to its role in causing the regression of...

Expression and antibacterial activity of hybrid antimicrobial peptide cecropinA-thanatin in Pichia pastoris

March 2018
Zeqiang Liu | Mingxing Zhu | Xiangjun Chen | Guimao Yang | Tiantian Yang | Longmei Yu | Liyuan Hui | Xiuqing Wang

The hybrid peptide CA(1–7)-T(4–19) gene was designed according to the N-terminal 1–7 amino acid sequence of the antimicrobial peptide cecropinA (CA) and the N-terminal 4–19 amino acid sequence of thanatin...

The pathogenesis of autoimmune hepatitis

March 2018
Mingxue Wang | Hua Zhang

Autoimmune hepatitis (AIH) is a liver inflammatory disease via induction of debris-like necrosis in the liver portal area, which is characterized by hypergammaglobulinemia and a variety of autoantibodies....

Synthesis of chitosan mediated silver nanoparticles (Ag NPs) for potential antimicrobial applications

March 2018
R. Kalaivani | M. Maruthupandy | T. Muneeswaran | A. Hameedha Beevi | M. Anand | C.M. Ramakritinan | A.K. Kumaraguru

•Synthesis of chitosan mediated silver nanoparticles (Ag NPs) using laser ablation method.•Characterization of synthesized Ag NPs was using UV, FTIR, XRD, AFM and TEM techniques.•Synthesized Ag NPs...

Detection of ESBL genes from ciprofloxacin resistant Gram negative bacteria isolated from urinary tract infections (UTIs)

March 2018
Govindan Rajivgandhi | Muthuchamy Maruthupandy | Govindan Ramachandran | Muthu Priyanga | Natesan Manoharan

Urinary tract infections (UTIs) are the most disregarded diseases in both developing and developed countries and accountable for one fourth of the health care related infections. Even though the women...

The analysis of the detection performance of nucleic acid testing and ELISA for HIV, HBV and HCB

December 2017
Wei Huang | Wei Wei | Xiao Tian Shi | Tianlun Jiang

To explore the clinical efficacy of Nucleic acid testing (NAT) in combination with Enzyme linked immunosorbent assay (ELISA)....

Highly crystalline sphere and rod-shaped TiO2 nanoparticles: A facile route to bio-polymer grafting

December 2017
Céline Falentin-Daudré | Jean-Sebastien Baumann | Véronique Migonney | Jolanda Spadavecchia

The goal of this report is to provide a versatile one step method based on UV irradiation in order to graft a bioactive polymer bearing sulfonate groups called poly(sodium styrene sulfonate) (polyNaSS)...

Guide for Authors

December 2017

Relationship between oxidative stress in patients with HBV-induced liver disease and HBV genotype/drug-resistant mutation

December 2017
Jia-fu Feng | Yu-wei Yang | Dong Wang | Jie Tang | Gang Xie | Ling-ying Fan

To explore the correlation of oxidative stress in patients with chronic hepatitis B and degree of severity of the disease with HBV genotype and drug-resistant mutation....

Graphene quantum dots in biomedical applications: Recent advances and future challenges

December 2017
Fei Chen | Weiyin Gao | Xiaopei Qiu | Hong Zhang | Lianhua Liu | Pu Liao | Weiling Fu | Yang Luo

Graphene quantum dots (GQDs)-based nanohybrid materials have gained great attention in multiple research applications, particularly in biomedical fields due to their unique physicochemical properties...

The association between long noncoding RNA H19 and pathological features in cancers: A meta-analysis

December 2017
Meng Cui | Qing Luo | Yi Zhang | Kaijiong Zhang | Jinbo Liu

Long noncoding RNA (lncRNA) H19 has been reported to be up-regulated and down-regulated in numerous tumors, but the relevance of clinical pathological features is not established. So, meta-analysis...

Small cell carcinoma of the endometrium: A case report with circulating tumor cell clusters

December 2017
Yongpeng He | Hai Huang | Haixia Wang | Lin Yi | Yichao Chen | Haiwei Zhang | Jing Ran | Hesong Shen | Qingming Jiang | Weiqi Nian

Primary small cell carcinoma (SCC) of the endometrium is a rare neuroendocrine tumor with aggressive behavior and poor prognosis, and no effective therapeutic method and prognosis monitoring were established....

Biological functions of miR-590 and its role in carcinogenesis

December 2017
Yang Dong | Guang-Bin Qiu

MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR)...

Opportunities and challenges for lung cancer screening in China

December 2017
Chuanli Ren | Chongxu Han

China accounts for nearly half of the incidence and mortality of lung cancer in the world. Furthermore, trends in lung cancer in China are increasing younger in age and the situation is deteriorating....

Using the VAP lipid panel for the detection, evaluation, and treatment of patients “at risk” for CAD

December 2017
Kenneth French | Yi Wang | Jianghua Jia | Yusheng Zhang

In the past several decades, multiple clinical trials have demonstrated the effects of dyslipidemia beyond low density lipoprotein cholesterol (LDL-C) on predicting risk for atherosclerosis and cardiovascular...

A simple assay for direct colorimetric detection of prostatic acid phosphatase (PAP) at fg levels using biphosphonated loaded PEGylated gold nanoparticles

December 2017
Maroua Ben Haddada | Fatima Aouidat | Maelle Monteil | Marc Lecouvey | Marc Lamy de la Chapelle | Jolanda Spadavecchia

A fast and sensitive colorimetric assay for the determination of prostatic acid phosphatase (PAP) levels using biphosphonates-PEG-coated gold nanoparticles (BP-PEG-AuNPs) has been developed. Addition...

Association between apolipoprotein C3 gene promoter polymorphisms and fasting triglyceride level: A meta-analysis

September 2017
Shi Cheng | Bo Pang | Chun Gu | Shi-Peng Sun | Cheng An | Zhen-Peng Zhang | Jun Li | Gui-Jian Liu

The apolipoprotein C3 gene (APOC3) polymorphisms were reported to be associated with lipid levels. But recent studies showed contradictory results about the associations between APOC3 rs854116 and rs2854117...

Study on CD4+T lymphocytes of new Uygur HIV infectors in Urumqi area

September 2017
Guohong Huang | Yanjie Cui | Zhiwei Li | Rui Huang | Changmin Wang

Objective: To understand the immune status of new Uygur HIV infectors in Urumqi area by detecting and analyzing CD4+T lymphocytes. Methods: Flow cytometry was used to detect absolute counts of CD4+T...

Green extraction of endemic plants to synthesize gold nanoparticles for theranostic applications

September 2017
Anne-Laure Morel | Sophie Giraud | Anne Bialecki | Hanane Moustaoui | Marc Lamy de La Chapelle | Jolanda Spadavecchia

We report a simple and original method to synthesize water-soluble gold nanoparticles in which a polyphenolic fraction, extracted by two plants originated from Reunion Island, was mixed to tetrachloroauric...

The application of Student’s t-test in internal quality control of clinical laboratory

September 2017
Yang-chun Feng | Yan-chun Huang | Xiu-min Ma

James O. Westgard advised that the relation between internal quality control (IQC) and statistical methods, such as t-test, should be seriously considered. The results of IQC fully fit in the requirements...

Release of cardiac troponin from healthy and damaged myocardium

September 2017
Alan H.B. Wu

Cardiac troponins T and I are proteins released into serum after cardiac injury, and are the standard biomarkers for patients presenting to the emergency department with a suspicion of acute myocardial...

High-sensitivity cardiac troponins I sandwich assay by immunomagnetic microparticle and quantum dots

September 2017
Hua Jiang | Jiapin Zhu | Wenwei Liu | Fengsheng Cao

High-sensitivity cardiac troponins I (hs-cTnI) has been endorsed as a standard biomarker for diagnosis of acute myocardial infarction (AMI) and can provide information for risk stratification. Our study...

First case of Kerstersia gyiorum isolated from a patient with chronic osteomyelitis in China

September 2017
You Lan | Qun Yan | Yuying Yan | Wenen Liu

Kerstersia gyiorum is a member of the family Alcaligenaceae and is infrequently isolated from clinical samples. Here we reported the isolation of K. gyiorum from a patient with chronic osteomyelitis....

Evaluation of EGF, EGFR, and E-cadherin as potential biomarkers for gastrointestinal cancers

September 2017
Liejun Jiang | Steven Hochwald | Shuang Deng | Yanhui Zhu | Chunyan Tan | Qiulian Zhong | Ying Zhou | Hongying Zhao | Huayi Huang

Biomarkers for early diagnosis and prognostic evaluation of cancers are still unsatisfactory in clinical management. The seeking of new biomarkers with better performance is still a challenge. EGF,...

Can gut flora changes be new biomarkers for depression?

September 2017
Ping Lin | Qingtian Li

Major depressive disorder is a serious mental health condition that involves increasing patients, medical care, economic burden and scientific problems. In these years, a lot of evidence is mounting...

Pegylated doxorubicin gold complex: From nanovector to potential intercalant agent for biosensor applications

September 2017
Valentina Melani | Maroua Ben Haddada | Hanane Moustaoui | Jessem Landoulsi | Nadia Djaker | Marc Lamy de la Chapelle | Jolanda Spadavecchia

We report an original approach to synthesize hybrid gold nanostructures in which doxorubicin (DOX), mixed to Poliethylenglycole diacid (PEG-COOH) led to original hybrid gold nanovector (DOX IN PEG AuNPs)....

Label-free techniques for laboratory medicine applications

June 2017
Xueping Chen | Yu Liu | Jiaoqi Huang | Wei Liu | Junfu Huang | Yang Zhang | Weiling Fu

New technologies and advanced methods are the important basis for continuous development of laboratory medicine. Although the labeling analysis has become an important research method in laboratory...

p62/SQSTM1: A potential molecular target for treatment of atherosclerosis

June 2017
Xiao-fei Liang | Xiu-ru Guan

Atherosclerosis is a chronic inflammatory disease, and multiple signaling pathways participate in its pathophysiological process. It has been generally recognized that macrophage autophagy is involved...

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