Enantioselective domino alkyl arylation of vinyl phosphonates by combining photoredox and nickel catalysis
Available online 9 April 2024
A nickel/photoredox mediated asymmetric domino alkyl arylation of vinyl phosphonates to generate a diverse array of enantioenriched α-aryl phosphonates is disclosed. This asymmetric three-component...
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N-Heterocyclic nitrenium-catalyzed photoreductive radical-polar crossover for alkene dicarbofunctionalization
Available online 18 March 2024
The photoredox radical-polar crossover paradigm is a valuable tool for 1,2-difunctionalization of alkenes. However, the use of unactivated alkyl halides as radical precursors remains far less developed....
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Unraveling chemical glycosylation: DFT insights into factors imparting stereoselectivity
Available online 15 March 2024
Stereoselective chemical glycosylation reactions are pivotal for preparing manifold biologically and medically important compounds, while mechanisms of chemical glycosylation reactions remain obscure...
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Photo- and electro-induced perfluoroalkylation/cyclization of o-hydroxyaryl enaminones: Synthesis of perfluoroalkyl chromones
Available online 13 March 2024
A practical, metal-, and additive-free strategy for photo- and electro-induced perfluoroalkylation/cyclization of o-hydroxyaryl enaminones with sodium perfluoroalkanesulfinates under mild conditions...
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Enantioselective synthesis of planar chiral ferrocenes via gold(I)-catalyzed hydroarylation of N-ferrocenyl propiolamides
Available online 8 March 2024
Herein, we report an intramolecular 6-endo-dig cyclization of N-ferrocenyl propiolamides for the synthesis of planar chiral ferrocenes enabled by gold(I)-catalyzed hydroarylation. By using this protocol,...
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Mild and green thioacylation with dithiocarboxylates via photoredox catalysis
Available online 7 March 2024
A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent. The...
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Simple nucleophile/H2O promoted defluorinative ring-opening of gem-difluorocyclopropenes
February 2024
A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good...
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Natural attapulgite supported nano-Ni catalysts for the efficient reductive amination of biomass-derived aldehydes and ketones
February 2024
The efficient synthesis of useful primary amines via reductive amination of biomass-based aldehydes and ketones over earth-abundant base metal catalysts is an attractive biomass value-adding technology...
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Sustainable electrochemical dearomatization for the synthesis of diverse 2, 3-functionalized indolines
February 2024
Herein, we achieved a green and efficient dearomatization for the synthesis of 2,3-functionalized polycyclic indolines in an electrochemical way. This avoiding of external oxidants and metals approach...
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Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines
February 2024
A catalyst-free and atom-economical [4 + 3] cycloaddition of azadienes with C,N-cyclic azomethine imines has been developed, providing an efficient and environmentally benign access to 1,2,4-triazepines...
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Visible-light-enabled multicomponent synthesis of trifluoromethylated 3-indolequinoxalin-2(1H)-ones without external photocatalysis
February 2024
A novel and sustainable visible-light-enabled multicomponent reaction involving quinoxalin-2(1H)-ones, indoles, and CF3SO2Na that does not require an external photocatalyst is described. This photoinduced...
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Visible-light-promoted tandem decarboxylation coupling/cyclization of N-aryl glycines with quinoxalinones: Easy access to tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
February 2024
A visible-light-promoted formal [2 + 2 + 1] cyclization of N-aryl glycines with quinoxalin-2(1H)-ones to synthesize tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones have been developed. The protocol...
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1,6-Conjugate addition of para-quinone methides using gem-diborylcarbanions: Practical access to gem-diborylalkanes bearing vicinal tertiary/quaternary stereocenters
February 2024
A novel, efficient and pragmatic method to prepare gem-diboron products with vicinal tertiary/quaternary stereocenters using LiTMP-mediated 1,6-conjugate addition of gem-diborylalkanes to para-quinone...
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Visible-light-induced decarboxylative alkynylation of carboxylic acids in batch and continuous flow
February 2024
A green efficient photoredox-catalyzed decarboxylative alkynylation of carboxylic acids with alkynyl bromides has been developed. This broadly applicable protocol is presented wherein α-amino, aliphatic...
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Photomediated core modification of diaryl dihydrophenzines through three-component alkylarylation of alkenes toward organocatalyzed ATRP
February 2024
The design and synthesis of a novel organic photocatalyst (OPC) have attracted broad interest from both the organic chemistry and polymer community. Herein, we presented a visible-light-induced alkylarylation...
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Photocatalytic generation of 1,4-disubstituted 1,2,3-triazoles under metal, oxidant and azide-free conditions
February 2024
Available online A mild and efficient photocatalytic-induced radical method has been developed for [4 + 1] cycloaddition reaction of 1,4-disubstituted 1,2,3-triazoles with N-tosylhydrazides and primary...
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Synthesis of biheteroaryls via 2-methyl quinoline C(sp3)-H functionalization under metal-free conditions
February 2024
An acetic acid-promoted C(sp3)-H functionalization of 2-methyl quinoline, enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Thioamide construction via sulfur interrupted Brook rearrangement
Available online 28 February 2024
Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis, employing acylsilanes in conjunction with diverse amines and elemental sulfur. The driving force of thioamidation...
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Palladium-catalyzed halosulfonylation of alkynes with ionic liquid as the green solvent and halide sources
Available online 26 February 2024
The first palladium-catalyzed halosulfonylation of alkynes with arylsulfonic acid under aerobic conditions was accomplished. This catalytic protocol provides a straightforward and effective synthetic...
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Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles
Available online 24 February 2024
Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel...
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1,5-Pentanediol production from 3,4-dihydro-2H-pyran and acetic acid via successive reactions of esterification and hydrogenation
Available online 24 February 2024
1,5-Pentanediol as an important chemical intermediate is commonly used for the manufacture of polyesters and polyurethanes. A novel process was developed for the production of bio-based 1,5-pentanediol...
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Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions
Available online 23 February 2024
The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na2S have been accomplished. This convenient and novel protocol involves the synthesis of valuable...
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Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
Available online 13 February 2024
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
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