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Most Downloaded Oncology Signaling Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Targeting cGMP/PKG signaling for the treatment or prevention of colorectal cancer with novel sulindac derivatives lacking cyclooxygenase inhibitory activity

Gary A. Piazza | Xi Chen | Antonio Ward | Alex Coley | Gang Zhou | Donald J. Buchsbaum | Yulia Maxuitenko | Adam B. Keeton

Approximately 28 million people in the United States have precancerous colonic adenomas with many at high risk of developing colorectal cancer who could benefit from a pharmacological approach to prevent...

2. Inhibition of dipeptidyl peptidase 4 (DPP4) activates immune cells chemotaxis in hepatocellular carcinoma

December 2019
Kristina Kovacovicova | Manlio Vinciguerra

A recent work by Nishina et al. provides new evidence that DPP4 inhibitors exert antitumor effects against hepatocellular carcinoma (HCC) by orchestrating immune responses....

3. Adequacy of sonographic guided fine needle aspiration cytology (FNAC) in abdominal lesions highlighting on malignant pathologies – A 10 year experience

December 2019
Evarisalin Marbaniang | Donboklang Lynser | Vandana Raphael | Akash Handique | Pranjal Phukan | Chhunthang Daniala | Yookarin Khonglah | Jaya Mishra | Biswajit Dey | Zachariah Chowdhury

To study on the adequacy of ultrasound guided FNACs in abdominal lesions and to evaluate and compare the adequate samples for malignant versus benign lesions and primary versus metastatic lesions in...

4. NEDD4 over-expression regulates the afatinib resistant phenotype of NSCLC cells

June 2018
Laurence Booth | Jane L. Roberts | Andrew Poklepovic | Paul Dent

We focused on defining the role of the E3 ligase NEDD4 in NSCLC cell afatinib resistance. Afatinib resistant H1975 clones over-expressed NEDD4 and c-MET compared to control clones and expressed less...

5. Regulation of c-Myc and NBS1 by ionizing radiation in glioblastoma cells

June 2018
Paulo Matheus Guerra Rodrigues | Roberto Salomon de Souza | Helena Lobo Borges | Rodrigo Alves Portela Martins

Glioblastoma is the most common primary brain tumor presenting the worst prognostic. Radioresistance of these tumors is barrier to better treatment and management. Cellular response to ionizing radiation...

6. Monoclonal antibody therapy in chronic lymphocytic leukemia

June 2018
Clive S. Zent

Optimal use of therapeutic monoclonal antibodies therapy requires an understanding of their mechanisms of action and how CLL cells resist these cytotoxic effects. This critical review details current...

7. Novel agents in the Canadian therapeutic landscape of chronic lymphocytic leukemia

June 2018
Anthea C. Peters | Andrei Fagarasanu

In this brief commentary, we discuss oral novel agents within in the armementarium of therapeutic options for Canadian patients with chronic lymphocytic leukemia (CLL). Previously limited to chemotherapy,...

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