A magnetic-enhanced FRET biosensor for simultaneous detection of multiple antibodies
June 2024
Accurate, rapid and sensitive detection of specific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies in human samples is crucial for preventing and assessing pandemics, especially in the...
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Investigating the anti-inflammatory and bone repair-promoting effects of an injectable porous hydrogel containing magnesium ions in a rat periodontitis mode
June 2024
Periodontitis is associated with several systemic diseases, and advanced periodontitis is often linked to an extensive inflammatory microenvironment and irregularly shaped alveolar bone defects. However,...
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Recent progress of 3D printed vascularized tissues and organs
June 2024
Since the need for vascular networks to supply oxygen and nutrients while expelling metabolic waste, most cells can only survive within 200 μm of blood vessels; thus, the construction of well-developed...
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Machine learning for polyphenol-based materials
June 2024
Polyphenol-based materials, primarily composed of polyphenolic compounds, have attracted considerable attention due to their unique chemical structures and biological activities. However, there are...
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Heparin-loaded hierarchical fiber/microsphere scaffolds for anti-inflammatory and promoting wound healing
June 2024
Chronic non-healing wounds induced by oxidative stress and inflammation can activate inflammatory cells and produce large amounts of inflammatory mediators, which fail to maintain homeostasis in the...
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Artificial intelligence (AI) meets biomaterials and biomedicine
June 2024
With the rapid progress of information technology and life sciences, artificial intelligence (AI) technology has substantially changed the way in many areas of biomaterials and biomedicine, including...
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Mechano-immunological checkpoints: An emerging strategy for investigation and evaluation of disease and therapeutics
June 2024
Over the past decades, increasing evidence has indicated that multiple mechanical signals with different magnitude and pattern, including fluid flow-derived shear stress, topology of extracellular matrix...
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Inhalable nanomedicine for lung cancer treatment
Available online 10 April 2024
Lung cancer has surpassed other types of cancer to become the primary cause of cancer-related deaths. Surgery stands as the foremost clinical treatment strategy available for tackling this condition,...
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Bioactive carbon dots for tissue engineering applications
March 2024
Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials with characteristic sizes of less than 10 nm. Recently, bioactive CDs have made remarkable achievements in wound healing, bone and...
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Real-time actuation of a dielectric elastomer actuator neuroprosthesis for facial paralysis
March 2024
Facial paralysis is a highly burdening condition, resulting in a patient's inability to move his mimic musculature on one or both sides of his face. This condition compromises the patient's communication...
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Magnetosurgery: Principles, design, and applications
March 2024
Magnetosurgery, the guidance or actuation of surgical instruments during operations using magnetic forces, has become a global trend in minimally invasive surgeries performed remotely. Despite the promise...
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Recent advances in three-dimensional printing in cardiovascular devices: Bench and bedside applications
March 2024
Three-dimensional (3D) printing is emerging as an innovative technology, which is widely used in cardiovascular disease at bench and bedside. During the last decade, with the development of 3D printing...
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Octopus -inspired gelatin-methacrylate scaffolds loaded with hBMSC-derived exosomes promote wound healing by regulating macrophage polarization
March 2024
Excessive local movement and inflammation are common problems in the process of wound repair, which lead to failure of later repair. In order to solve this problem, inspired by the octopus sucker structure,...
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The marine natural product trichobotrysin B inhibits proliferation and promotes apoptosis of human glioma cells via the IL-6-mediated STAT3/JAK signaling pathway
March 2024
Glioma is the most common malignant tumor of the central nervous system. Drug-assisted chemotherapy is an important adjuvant treatment post-surgery, but currently, effective chemotherapy drugs for glioma...
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Optical nanoprobes in biomedical diagnosis assays: Recent progress
March 2024
Biomedical assays based on optical nanoprobes play an important role in human health. Optical nanoprobes, the nanomaterials with special optical properties, are widely utilized in biomedical assays....
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Enhancing bone regeneration with a novel bioactive glass-functionalized polyetheretherketone scaffold by regulating the immune microenvironment
March 2024
Polyetheretherketone (PEEK) has become a promising material for bone engineering due to its excellent mechanical properties, radiolucency and chemical resistance. However, its inherent bioinertness...
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A detailed protocol for cell force measurement by traction force microscopy
March 2024
Cellular traction forces (CTFs) are generated by adherent cells and involved in regulating migration, morphology, and homeostasis. Accurate measurement of CTFs is crucial for understanding fundamental...
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Potentiating sorafenib efficacy against hepatocellular carcinoma via a carrier-free nanomedicine of artesunate prodrug
March 2024
Sorafenib is a first-line drug for liver cancer treatment, but its clinical efficacy is still limited by drawbacks such as drug tolerance, toxic effects, and low bioavailability. Therefore, it is urgent...
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Optimising degradation and mechanical performance of additively manufactured biodegradable Fe–Mn scaffolds using design strategies based on triply periodic minimal surfaces
March 2024
Additively manufactured lattices based on triply periodic minimal surfaces (TPMS) have attracted significant research interest from the medical industry due to their good mechanical and biomorphic properties....
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Smartphone-based polydiacetylene colorimetric sensor for point-of-care diagnosis of bacterial infections
March 2024
The rapid progress in point-of-care testing (POCT) has become a promising decentralized patient-centered approach for the control of infectious diseases, especially in resource-limited settings. POCT...
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Hydrogel wound dressings containing bioactive compounds originated from traditional Chinese herbs: A review
March 2024
Various factors can cause skin defects, resulting in the loss of physiological functions and even death due to severe concurrent infection. Dressings are often clinically used to fully cover the wounds...
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Anti-fouling coatings for blood-contacting devices
March 2024
Blood-contacting medical devices, such as vascular stents, intravascular catheters, and artificial heart valves, frequently encounter complications in clinical practice, including thrombosis, inflammatory...
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Hydrogel-fiber-mesh-based 3D cell cultures: A new method for studying pituitary tumors
Available online 27 March 2024
Acromegaly is a challenging medical condition that arises from the excessive production of growth hormones and the insulin-like growth factor 1 in the pituitary gland. While surgery is the primary treatment...
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Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy
Available online 23 March 2024
Although characterized by high reactive oxygen species (ROS) generation, cancer cells maintain redox homeostasis to avoid severe damage (e.g., DNA, protein, and plasma membrane dysfunction) and facilitate...
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Biofabrication of natural Au/bacterial cellulose hydrogel for bone tissue regeneration via in-situ fermentation
2023
Bacterial cellulose (BC) possesses the desirable properties of biocompatibility, high porosity, high surface area and noticeable mechanical strength as a scaffold in bone tissue engineering. However,...
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