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Most Downloaded Chronic Diseases and Translational Medicine Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19)

June 2020
Lu-Lu Yang | Ting Yang

As a highly infectious respiratory tract disease, coronavirus disease 2019 (COVID-19) can cause respiratory, physical, and psychological dysfunction in patients. Therefore, pulmonary rehabilitation...

2. Expert recommendations on blood purification treatment protocol for patients with severe COVID-19

June 2020
Xiang-Hong Yang | Ren-Hua Sun | Ming-Yan Zhao | Er-Zhen Chen | Jiao Liu | Hong-Liang Wang | Rong-Li Yang | De-Chang Chen

Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international...

3. Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients

June 2020
Chun-Rong Ju | Qiao-Yan Lian | Jian-Heng Zhang | Tao Qiu | Zhi-Tao Cai | Wen-Yang Jiang | Jing Zhang | Qin Cheng | Gang Chen | Ning Li | Chun-Yan Wang | Jian-Xing He

Since December 2019, increasing attention has been paid to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Wuhan, China. SARS-CoV-2 primarily invades the respiratory tract...

4. Management recommendations for patients with chronic kidney disease during the novel coronavirus disease 2019 (COVID-19) epidemic

June 2020
Juan Li | Shuang-Xi Li | Li-Fang Zhao | De-Liang Kong | Zhi-Yong Guo

COVID-19 has become a pandemic and it has already spread to at least 171 countries/regions. Chronic kidney disease (CKD) is a global public health problem with a total of approximately 850 million patients...

5. Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019

June 2020
Meng-Yuan Liu | Bo Zheng | Yan Zhang | Jian-Ping Li

Coronavirus disease 2019 is a major threat to public health globally. Though its pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has been recently identified as a...

6. Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

December 2019
Amin Zargar | Samantha Chang | Ankita Kothari | Antoine M. Snijders | Jian-Hua Mao | Jessica Wang | Amanda C. Hernández | Jay D. Keasling | Trever G. Bivona

Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms,...

7. Recommendations for prevention and management of COVID-19 in peritoneal dialysis patients

June 2020
Xue-Li Lai | Hai-Yan Wang | Zhi-Yong Guo

The World Health Organization characterized coronavirus disease (COVID-19) as a pandemic on March 11, 2020. Peritoneal dialysis patients have a weakened immune system that is associated with a high...

8. Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

March 2020
Ke-Yu Li | Jia-Long Yuan | Diego Trafton | Jian-Xin Wang | Nan Niu | Chun-Hui Yuan | Xu-Bao Liu | Lei Zheng

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune...

9. Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China

September 2018
Tao Li | Rong Hu | Zi Chen | Qiyuan Li | Shouxiong Huang | Zhou Zhu | Lin-Fu Zhou

Air pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China....

11. Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations

December 2019
Chao Peng | Yi Hu | Zhong-Ming Ge | Quan-Ming Zou | Nong-Hua Lyu

Helicobacter pylori (H. pylori) infection is associated with various gastric and extra-gastric diseases. Importantly, this infection is the strongest known risk factor for gastric cancer (GC). H. pylori...

12. Current advances in Hodgkin’s lymphoma

March 2019
Joseph Vadakara | Benjamin Andrick

Hodgkin’s lymphoma is a highly treatable malignancy. It has high cure rates yet there are many patients who relapse or are refractory to treatment. Traditionally, treatment has been with conventional...

13. Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

June 2019
Chun-Song Hu | Qing-Hua Wu | Da-Yi Hu | Tengiz Tkebuchava

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes...

14. Air pollutants and early origins of respiratory diseases

June 2018
Dasom Kim | Zi Chen | Lin-Fu Zhou | Shou-Xiong Huang

Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants...

15. Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

March 2018
Vincenzo Bellizzi | Patrizia Calella | Juan Jesus Carrero | Denis Fouque

The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but...

16. Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

December 2018
Camilla P. Stice | Hui Xia | Xiang-Dong Wang

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol...

17. New advances in the diagnosis of primary aldosteronism

March 2020
Hang Shen | Zhi-Xin Xu | Qi-Fu Li

Primary aldosteronism (PA) is a common form of endocrine hypertension. The diagnostic process of PA includes a screening test, confirmatory test, and subtype classification. In this review, we have...

18. The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

September 2019
Chun-Hui Sun | Bin-Bin Li | Bo Wang | Jing Zhao | Xiao-Ying Zhang | Ting-Ting Li | Wen-Bing Li | Di Tang | Miao-Juan Qiu | Xin-Cheng Wang | Cheng-Ming Zhu | Zhi-Rong Qian

Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue;...

19. Environmental heavy metals and cardiovascular diseases: Status and future direction

Available online 3 April 2020
Ai-Min Yang | Kenneth Lo | Tong-Zhang Zheng | Jing-Li Yang | Ya-Na Bai | Ying-Qing Feng | Ning Cheng | Si-Min Liu

Cardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly...

20. Targeting MET in cancer therapy

September 2017
Hong-Nan Mo | Peng Liu

MET encodes a receptor tyrosine kinase c-MET for hepatocyte growth factor (HGF). The specific combination of c-MET and HGF activates downstream signaling pathways to trigger cell migration, proliferation,...

21. Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

September 2020
Zhi Zhu | Ying-Bo Gong | Hui-Mian Xu

Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival...

22. Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy

September 2019
Bin-Bin Li | Bo Wang | Cheng-Ming Zhu | Di Tang | Jun Pang | Jing Zhao | Chun-Hui Sun | Miao-Juan Qiu | Zhi-Rong Qian

Current cancer therapies have encountered adverse response due to poor therapeutic efficiency, severe side effects and acquired resistance to multiple drugs. Thus, there are urgent needs for finding...

23. Cross-talk between Myc and p53 in B-cell lymphomas

September 2019
Li Yu | Tian-Tian Yu | Ken H. Young

Myc and p53 proteins are closely associated with many physiological cellular functions, including immune response and lymphocyte survival, and are expressed in the lymphoid organs, which are sites for...

24. Effects of particulate matter on allergic respiratory diseases

June 2018
Jin-Zhun Wu | Dan-Dan Ge | Lin-Fu Zhou | Ling-Yun Hou | Ying Zhou | Qi-Yuan Li

The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with...

25. Frequent exercise: A healthy habit or a behavioral addiction?

December 2016
Wan-Jing Chen

It is well known that regular physical activity helps improve overall health and fitness and reduces the risk of many chronic diseases. However, excessive exercise might be harmful. Exercise addiction...

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