English English | 中文 中文

Recent Chronic Diseases and Translational Medicine Articles

Recently published articles from Chronic Diseases and Translational Medicine.

Ten-eleven translocation-2 affects the fate of cells and has therapeutic potential in digestive tumors

Available online 8 January 2020
Feng Wang | Jing Zhang | Jian Qi

Ten-eleven translocation (TET) methylcytosine dioxygenases catalyze the oxidative reactions of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine...

Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease

Available online 8 January 2020
Qin Zhou | Wei Chen | Xue-Qing Yu

Long non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development...

Challenge in the new era: Translational medicine in gastrointestinal endoscopy and early cancer

Available online 8 January 2020
Yang Yu | Yan-Hua Yin | Li Min | Sheng-Tao Zhu | Peng Li | Shu-Tian Zhang

Translational medicine is a new medical model that has emerged over the past 20 years and is dedicated to bridging the gap between basic and clinical research. At the same time, the diagnosis and treatment...

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

Available online 8 January 2020
Amin Zargar | Samantha Chang | Ankita Kothari | Antoine M. Snijders | Jian-Hua Mao | Jessica Wang | Amanda C. Hernández | Jay D. Keasling | Trever G. Bivona

Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms,...

Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations

Available online 8 January 2020
Chao Peng | Yi Hu | Zhong-Ming Ge | Quan-Ming Zou | Nong-Hua Lyu

Helicobacter pylori (H. pylori) infection is associated with various gastric and extra-gastric diseases. Importantly, this infection is the strongest known risk factor for gastric cancer (GC). H. pylori...

Relevance of SYNTAX score for assessment of saphenous vein graft failure after coronary artery bypass grafting

Available online 3 December 2019
Jia-Hui Li | Xian-Tao Song | Xue-Yao Yang | Wen-Yi Zhang | Hao-Ran Xing

To identify risk factors of saphenous vein graft (SVG) failure and to investigate the utility of anatomical SYNTAX score (SS) and SYNTAX score II (SS-II) in predicting SVG failure....

Development and preliminary verification of the evaluation system for clinical practice guidelines in China

Available online 17 October 2019
Ji-Yao Wang | Qiang Wang | Xiao-Qin Wang | Xue-Juan Jin | Bo-Heng Zhang | Shi-Yao Chen | Xue-Cheng Gao

Clinical practice guidelines can improve healthcare processes and patient outcomes; however, the quality of these guidelines varies greatly in China. The aim of this study was to construct a comprehensive...

Guide for Authors

September 2019

Cross-talk between Myc and p53 in B-cell lymphomas

September 2019
Li Yu | Tian-Tian Yu | Ken H. Young

Myc and p53 proteins are closely associated with many physiological cellular functions, including immune response and lymphocyte survival, and are expressed in the lymphoid organs, which are sites for...

Who benefits from R0 resection? A single-center analysis of patients with stage Ⅳ gallbladder cancer

September 2019
Chen Chen | Lin Wang | Rui Zhang | Qi Li | Ya-Ling Zhao | Guan-Jun Zhang | Wen-Zhi Li | Zhi-Min Geng

Most patients with gallbladder cancer (GBC) present with advanced-stage disease and have a poor prognosis. Radical resection remains the only therapeutic option to improve survival in patients with...

Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy

September 2019
Bin-Bin Li | Bo Wang | Cheng-Ming Zhu | Di Tang | Jun Pang | Jing Zhao | Chun-Hui Sun | Miao-Juan Qiu | Zhi-Rong Qian

Current cancer therapies have encountered adverse response due to poor therapeutic efficiency, severe side effects and acquired resistance to multiple drugs. Thus, there are urgent needs for finding...

Incidence and mortality of liver cancer in Henan province in 2015

September 2019
Xiao-Qin Cao | Ru-Fei Cao | Shu-Zheng Liu | Qiong Chen | Pei-Liang Quan | Su-Xia Luo

Liver cancer is one of the most common types of cancer. We aimed to use the cancer registration data in 2015 to estimate the incidence and mortality of liver cancer in Henan province....

The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

September 2019
Chun-Hui Sun | Bin-Bin Li | Bo Wang | Jing Zhao | Xiao-Ying Zhang | Ting-Ting Li | Wen-Bing Li | Di Tang | Miao-Juan Qiu | Xin-Cheng Wang | Cheng-Ming Zhu | Zhi-Rong Qian

Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue;...

Programmed death ligand-1/programmed death-1 inhibition therapy and programmed death ligand-1 expression in urothelial bladder carcinoma

September 2019
Wei-Bo Yu | Jian-Yu Rao

After two decades of unchanged paradigms, the treatment strategies for advanced urothelial bladder cancer have been revolutionized by emerging programmed death ligand-1 (PD-L1)/programmed death-1 (PD1)...

Thirdhand smoke: Genotoxicity and carcinogenic potential

Available online 26 September 2019
Bo Hang | Pin Wang | Yue Zhao | Hang Chang | Jian-Hua Mao | Antoine M. Snijders

Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread...

Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers

June 2019
Ai-Min Yang | Xiao-Bin Hu | Simin Liu | Ning Cheng | De-Sheng Zhang | Juan-Sheng Li | Hai-Yan Li | Xiao-Wei Ren | Na Li | Xi-Pin Sheng | Jiao Ding | Shan Zheng | Min-Zheng Wang | Tong-Zhang Zheng | Ya-Na Bai

Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol...

Symptom frequency and development of a generic functional disorder symptom scale suitable for use in studies of patients with irritable bowel syndrome, fibromyalgia syndrome or chronic fatigue syndrome

June 2019
Michael E. Hyland | Alison M. Bacon | Joseph W. Lanario | Anthony F. Davies

To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom...

Association of handgrip strength with the prevalence of hypertension in a Chinese Han population

June 2019
Manthar Ali Mallah | Min Liu | Yu Liu | Hai-Feng Xu | Xiao-Jun Wu | Xiao-Tian Chen | Hui Wang | Chun-Lan Liu | Yuan-Rui Tian | Meng-Xia Li | Qun Li | Jun Fu | Chong Shen

Handgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a...

Preferences and attitudes of young Chinese clinicians about using a shared decision making tools for communicating cardiovascular risk

June 2019
Rong-Chong Huang | Xian-Tao Song | Dong-Feng Zhang | Jia-Ying Xu | Kasey R. Boehmer | Aaron A. Leppin | Michael R. Gionfriddo | Henry H. Ting | Victor M. Montori

This study assesses the attitudes and preferences of Chinese clinicians toward their involvement in shared decision making (SDM)....

Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

June 2019
Chun-Song Hu | Qing-Hua Wu | Da-Yi Hu | Tengiz Tkebuchava

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes...

Fasting glucose and its association with 20-year all-cause and cause-specific mortality in Chinese general population

June 2019
Long Zhou | Jin-Zhuang Mai | Ying Li | Yong Wu | Min Guo | Xiang-Min Gao | Yang-Feng Wu | Lian-Cheng Zhao | Xiao-Qing Liu

The aim of this study was to explore the relationship between fasting glucose levels and all-cause and cause-specific mortality in Chinese population....

Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults

June 2019
Zhen-Zhen Zhang | Ping Wang | Xiang-Lei Kong | Wen-Li Mao | Mei-Yu Cui

Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse...

Current advances in Hodgkin’s lymphoma

March 2019
Joseph Vadakara | Benjamin Andrick

Hodgkin’s lymphoma is a highly treatable malignancy. It has high cure rates yet there are many patients who relapse or are refractory to treatment. Traditionally, treatment has been with conventional...

Managing cardiotoxicity associated with immune checkpoint inhibitors

March 2019
Sireesha Upadhrasta | Hadi Elias | Keval Patel | Lei Zheng

Immuno-oncology is a fast evolving field of cancer therapy and immune checkpoint inhibitors (ICIs) are clearly a breakthrough in this field. Cardiotoxicity with conventional anti-cancer therapies has...

Apoptosis of mesenchymal stem cells is regulated by Rspo1 via the Wnt/β-catenin signaling pathway

March 2019
Xiao-Xia Cheng | Qiao-Yan Yang | Yong-Li Qi | Zhi-Zhen Liu | Dan Liu | Sheng He | Li-Hong Yang | Jun Xie

The aim of this study was to investigate the effect and possible mechanism of action of roof plate-specific spondin1 (Rspo1) in the apoptosis of rat bone marrow mesenchymal stem cells (BMSCs)....

Evidence-based medicine in China

March 2019
Ji-Yao Wang | Xue-Juan Jin

Advances in reducing cardiovascular risk in the management of patients with type 2 diabetes mellitus

March 2019
Ying Hu

Treatment intended to lower cardiovascular (CV) risk in patients with diabetes has always been a primary goal of diabetes treatment. Due to the subdued effects of reducing hemoglobin A1c (HbA1c) on...

Association between timing of peritoneal dialysis initiation and mortality in end-stage renal disease

March 2019
Yuan Peng | Xiao Yang | Wei Chen | Xue-Qing Yu

Despite the widespread use of chronic dialysis for end-stage renal disease (ESRD), there is no consensus on the optimal timing of initiating renal replacement therapy. Over the past decade, a worldwide...

Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer

March 2019
Liang-Yu Bie | Dan Li | Yu Mu | Sheng Wang | Bei-Bei Chen | Hui-Fang Lyu | Li-Li Han | Cai-Yun Nie | Chang-Cheng Yang | Lin Wang | Chuan-Chuan Ren | Wei-Jie Zhang | Ping Guo | Feng Shi | Qing-Xia Fan | Liu-Xing Wang | Xiao-Bing Chen | Su-Xia Luo

To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment....

Artificial intelligence—Developments in medicine in the last two years

March 2019
Rezida Maratovna Galimova | Igor Vyacheslavovich Buzaev | Kireev Ayvar Ramilevich | Lev Khadyevich Yuldybaev | Aigul Fazirovna Shaykhulova

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

December 2018
Camilla P. Stice | Hui Xia | Xiang-Dong Wang

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol...

Hospital length of stay and healthcare costs among African American women due to obesity and diabetic conditions in United States: A model for correlation studies comparing ethnicity, co-morbidities and hospital resources

December 2018
Terris R. Moss

To examine obesity and diabetes associations with United States hospital use and healthcare costs for African American women, to explore the relationship between co-morbidities of interest (obesity...

Isoniazid-induced liver disorder in the treatment of tuberculosis

December 2018
Srinivasan Sivannan | Atukuri Vishnuvardhan | Karthikeyan Elumalai | Sivaneswari Srinivasan | Kalpana Eluri | Manogaran Elumalai | Ramasamy Muthu

Chimeric antigen receptor modified T-cells for cancer treatment

December 2018
Xiao Han | Yao Wang | Wei-Dong Han

T cells engineered with the chimeric antigen receptor (CAR) are rapidly emerging as an important immunotherapy for hematologic malignancies. The anti-cluster of differentiation (CD)19 CAR-T cell therapy...

Selectins modify dendritic cells during atherosclerosis

December 2018
Zhi-Shuai Ye | Rong-Chong Huang

Dendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune...

Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

December 2018
Xiang-Lei Kong | Xiao-Jing Ma | Cheng-Yin Zhang | Dong-Mei Xu

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Previous studies have indicated that clustering of major CVD risk factors is common. We aimed to explore the association...

Percutaneous left ventricular assist device vs. intra-aortic balloon pump in patients with severe left ventricular dysfunction undergoing cardiovascular intervention: A meta-analysis

December 2018
Fang-Bin Hu | Lian-Qun Cui

Although controversial, the intra-aortic balloon pump (IABP) and percutaneous left ventricular assist device (PLVAD) are widely used for initial hemodynamic stabilization. We performed a meta-analysis...

Guide for Authors

September 2018

Systemic treatment for hepatocellular carcinoma

September 2018
Manushi Aggarwal | Abeer Arain | Zhaohui Jin

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality worldwide. Treatment options for patients with advanced stage HCC remain a great challenge. However, novel agents...

Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review

September 2018
Meri R. Räihä | Pauli A. Puolakkainen

Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection...

Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China

September 2018
Tao Li | Rong Hu | Zi Chen | Qiyuan Li | Shouxiong Huang | Zhou Zhu | Lin-Fu Zhou

Air pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China....

Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside

September 2018
Yong-Xi Chen | Xiao-Nong Chen

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with...

Progress in targeted therapy for breast cancer

September 2018
Jie Ju | An-Jie Zhu | Peng Yuan

Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade. Due to the further...

Usefulness of upright T wave in lead aVR for predicting short-term prognosis of patients with ischemic stroke

September 2018
Hong-Jie Yang | Xin Liu | Chuan Qu | Shao-Bo Shi | Bo Yang

Upright T wave in lead aVR (TaVR) has recently been reported to be associated with cardiovascular death and mortality in general population and in patients with prior cardiovascular disease (CVD). However,...

Chronic lung disease, lung regeneration and future therapeutic strategies

June 2018
Xuan-Ye Cao | Si-Yu Xiao

Chronic lung diseases have been recognized as one of the world's leading causes of death in recent decades. Lacking effective treatments brings the patients not only bad quality of life but also higher...

Effects of particulate matter on allergic respiratory diseases

June 2018
Jin-Zhun Wu | Dan-Dan Ge | Lin-Fu Zhou | Ling-Yun Hou | Ying Zhou | Qi-Yuan Li

The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with...

Air pollutants and early origins of respiratory diseases

June 2018
Dasom Kim | Zi Chen | Lin-Fu Zhou | Shou-Xiong Huang

Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants...

Share this page: