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Recent Chronic Diseases and Translational Medicine Articles

Recently published articles from Chronic Diseases and Translational Medicine.

Managing cardiotoxicity associated with immune checkpoint inhibitors

Available online 21 March 2019
Sireesha Upadhrasta | Hadi Elias | Keval Patel | Lei Zheng

Immuno-oncology is a fast evolving field of cancer therapy and immune checkpoint inhibitors (ICIs) are clearly a breakthrough in this field. Cardiotoxicity with conventional anti-cancer therapies has...

Evidence-based medicine in China

Available online 20 March 2019
Ji-Yao Wang | Xue-Juan Jin

Apoptosis of mesenchymal stem cells is regulated by Rspo1 via the Wnt/β-catenin signaling pathway

Available online 19 March 2019
Xiao-Xia Cheng | Qiao-Yan Yang | Yong-Li Qi | Zhi-Zhen Liu | Dan Liu | Sheng He | Li-Hong Yang | Jun Xie

The aim of this study was to investigate the effect and possible mechanism of action of Rspo1 in the apoptosis of rat bone marrow mesenchymal stem cells (BMSCs)....

Current advances in Hodgkin’s lymphoma

Available online 19 March 2019
Joseph Vadakara | Benjamin Andrick

Hodgkin’s lymphoma is a highly treatable malignancy. It has high cure rates yet there are many patients who relapse or are refractory to treatment. Traditionally, treatment has been with conventional...

Advances in reducing cardiovascular risk in the management of patients with type 2 diabetes mellitus

Available online 15 March 2019
Ying Hu

Treatment intended to lower cardiovascular (CV) risk in patients with diabetes has always been a primary goal of diabetes treatment. Due to the subdued effects of reducing hemoglobin A1c (HbA1c) on...

Artificial intelligence—Developments in medicine in the last two years

Available online 9 January 2019
Rezida Maratovna Galimova | Igor Vyacheslavovich Buzaev | Kireev Ayvar Ramilevich | Lev Khadyevich Yuldybaev | Aigul Fazirovna Shaykhulova

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

December 2018
Camilla P. Stice | Hui Xia | Xiang-Dong Wang

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol...

Hospital length of stay and healthcare costs among African American women due to obesity and diabetic conditions in United States: A model for correlation studies comparing ethnicity, co-morbidities and hospital resources

December 2018
Terris R. Moss

To examine obesity and diabetes associations with United States hospital use and healthcare costs for African American women, to explore the relationship between co-morbidities of interest (obesity...

Isoniazid-induced liver disorder in the treatment of tuberculosis

December 2018
Srinivasan Sivannan | Atukuri Vishnuvardhan | Karthikeyan Elumalai | Sivaneswari Srinivasan | Kalpana Eluri | Manogaran Elumalai | Ramasamy Muthu

Chimeric antigen receptor modified T-cells for cancer treatment

December 2018
Xiao Han | Yao Wang | Wei-Dong Han

T cells engineered with the chimeric antigen receptor (CAR) are rapidly emerging as an important immunotherapy for hematologic malignancies. The anti-cluster of differentiation (CD)19 CAR-T cell therapy...

Selectins modify dendritic cells during atherosclerosis

December 2018
Zhi-Shuai Ye | Rong-Chong Huang

Dendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune...

Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

December 2018
Xiang-Lei Kong | Xiao-Jing Ma | Cheng-Yin Zhang | Dong-Mei Xu

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Previous studies have indicated that clustering of major CVD risk factors is common. We aimed to explore the association...

Percutaneous left ventricular assist device vs. intra-aortic balloon pump in patients with severe left ventricular dysfunction undergoing cardiovascular intervention: A meta-analysis

December 2018
Fang-Bin Hu | Lian-Qun Cui

Although controversial, the intra-aortic balloon pump (IABP) and percutaneous left ventricular assist device (PLVAD) are widely used for initial hemodynamic stabilization. We performed a meta-analysis...

Association between timing of peritoneal dialysis initiation and mortality in end-stage renal disease

Available online 21 December 2018
Yuan Peng | Xiao Yang | Wei Chen | Xue-Qing Yu

Despite the widespread use of chronic dialysis for end-stage renal disease (ESRD), there is no consensus on the optimal timing of initiating renal replacement therapy. Over the past decade, a worldwide...

Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

Available online 13 November 2018
Chun-Song Hu | Qing-Hua Wu | Da-Yi Hu | Tengiz Tkebuchava

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes...

Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer

Available online 23 October 2018
Liang-Yu Bie | Dan Li | Yu Mu | Sheng Wang | Bei-Bei Chen | Hui-Fang Lyu | Li-Li Han | Cai-Yun Nie | Chang-Cheng Yang | Lin Wang | Chuan-Chuan Ren | Wei-Jie Zhang | Ping Guo | Feng Shi | Qing-Xia Fan | Liu-Xing Wang | Xiao-Bing Chen | Su-Xia Luo

To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment....

Guide for Authors

September 2018

Systemic treatment for hepatocellular carcinoma

September 2018
Manushi Aggarwal | Abeer Arain | Zhaohui Jin

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality worldwide. Treatment options for patients with advanced stage HCC remain a great challenge. However, novel agents...

Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: A review

September 2018
Meri R. Räihä | Pauli A. Puolakkainen

Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection...

Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China

September 2018
Tao Li | Rong Hu | Zi Chen | Qiyuan Li | Shouxiong Huang | Zhou Zhu | Lin-Fu Zhou

Air pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China....

Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside

September 2018
Yong-Xi Chen | Xiao-Nong Chen

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with...

Progress in targeted therapy for breast cancer

September 2018
Jie Ju | An-Jie Zhu | Peng Yuan

Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade. Due to the further...

Usefulness of upright T wave in lead aVR for predicting short-term prognosis of patients with ischemic stroke

September 2018
Hong-Jie Yang | Xin Liu | Chuan Qu | Shao-Bo Shi | Bo Yang

Upright T wave in lead aVR (TaVR) has recently been reported to be associated with cardiovascular death and mortality in general population and in patients with prior cardiovascular disease (CVD). However,...

Fasting glucose and its association with 20-year all-cause and cause-specific mortality in Chinese general population

Available online 25 September 2018
Long Zhou | Jin-Zhuang Mai | Ying Li | Yong Wu | Min Guo | Xiang-Min Gao | Yang-Feng Wu | Lian-Cheng Zhao | Xiao-Qing Liu

The aim of this study was to explore the relationship between fasting glucose levels and all-cause and cause-specific mortality in Chinese population....

Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults

Available online 12 July 2018
Zhen-Zhen Zhang | Ping Wang | Xiang-Lei Kong | Wen-Li Mao | Mei-Yu Cui

Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse...

DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer

June 2018
Xin (Eric) Jiang | Ting Xu | Qingyi Wei | Peng Li | Daniel R. Gomez | Laurence E. Court | Zhongxing Liao

The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in...

Chronic lung disease, lung regeneration and future therapeutic strategies

June 2018
Xuan-Ye Cao | Si-Yu Xiao

Chronic lung diseases have been recognized as one of the world's leading causes of death in recent decades. Lacking effective treatments brings the patients not only bad quality of life but also higher...

Effects of particulate matter on allergic respiratory diseases

June 2018
Jin-Zhun Wu | Dan-Dan Ge | Lin-Fu Zhou | Ling-Yun Hou | Ying Zhou | Qi-Yuan Li

The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with...

Air pollutants and early origins of respiratory diseases

June 2018
Dasom Kim | Zi Chen | Lin-Fu Zhou | Shou-Xiong Huang

Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants...

In-hospital direct costs for thromboembolism and bleeding in Chinese patients with atrial fibrillation

June 2018
San-Shuai Chang | Jia-Hui Wu | Yi Liu | Ting Zhang | Xin Du | Jian-Zeng Dong | Gregory Y.H. Lip | Chang-Sheng Ma

Limited data are available on the direct costs of hospitalization owing to thromboembolism and bleeding in patients with atrial fibrillation (AF) in China. Such data are essential for policy development,...

Novel findings in relation to multiple anti-atherosclerotic effects of XueZhiKang in humans

June 2018
Rui-Xia Xu | Yan Zhang | Yuan-Lin Guo | Chun-Yan Ma | Yu-Hong Yao | Sha Li | Xiao-Lin Li | Ping Qing | Ying Gao | Na-Qiong Wu | Cheng-Gang Zhu | Geng Liu | Qian Dong | Jing Sun | Jian-Jun Li

Previous studies have clearly demonstrated that XueZhiKang (XZK), an extract of cholestin, can decrease low-density lipoprotein cholesterol (LDL-C) and cardiovascular events. However, the mechanism...

WITHDRAWN: Anti-p53 autoantibody as a diagnostic biomarker for non-small cell lung cancer: A meta-analysis

Available online 7 June 2018
Cai-Xia Liang | Yuan-Kai Shi | Xiao-Hong Han

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause....

Functional promoter rs189037 variant of ATM is associated with decrease in lung diffusing capacity after irradiation for non–small-cell lung cancer

March 2018
Jose Luis Lopez Guerra | Yi-Peng Song | Quynh-Nhu Nguyen | Daniel R. Gomez | Zhongxing Liao | Ting Xu

Single-nucleotide polymorphisms (SNPs) in the ataxia telangiectasia–mutated gene ATM have been linked with pneumonitis after radiotherapy for lung cancer but have not been evaluated in terms of pulmonary...

Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies

March 2018
Rui-Fang Sun | Qian-Qian Yu | Ken H. Young

Accumulating evidence confirmed that many dysregulated signaling pathways and aberrant genetic alterations contribute to the oncogenesis and heterogeneity of lymphoid malignancies. Therapeutically targeting...

Customization of therapy for gastroesophageal adenocarcinoma patients

March 2018
Dilsa Mizrak Kaya | Kazuto Harada | Fatemeh G. Amlashi | Maria Vasilakopoulou | Jaffer A. Ajani

Gastroesophageal adenocarcinomas (GEACs) remain a global health problem. These are most often diagnosed at advanced stage and the estimated 5-year relative survival rate is about 5%. Although cure is...

Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

March 2018
Vincenzo Bellizzi | Patrizia Calella | Juan Jesus Carrero | Denis Fouque

The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but...

Quantitative image analysis for evaluation of tumor response in clinical oncology

March 2018
Wen-Li Cai | Guo-Bin Hong

The objective, accurate, and standardized evaluation of tumor response to treatment is an indispensable procedure in clinical oncology. Compared to manual measurement, computer-assisted linear measurement...

Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma

December 2017
Lin-Shu Zeng | Wen-Ting Huang | Tian Qiu | Ling Shan | Lei Guo | Jian-Ming Ying | Ning Lyu | Xiao-Li Feng

To investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTCL)....

Current progress and outcomes of clinical trials on using epidermal growth factor receptor-tyrosine kinase inhibitor therapy in non-small cell lung cancer patients with brain metastases

December 2017
Ling-Ling Kong | Lin-Lin Wang | Li-Gang Xing | Jin-Ming Yu

Non-small cell lung cancer (NSCLC) continues to be one of the major causes of cancer-related deaths worldwide, and brain metastases are the major cause of death in NSCLC patients. With recent advances...

Are statins beneficial for the treatment of pulmonary hypertension?

December 2017
Lei Wang | Ting Yang | Chen Wang

Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary...

Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular diseases

December 2017
Jun-Xuan Lv | Qi Kong | Xin Ma

Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory...

Intracranial artery stenosis: Current status of evaluation and treatment in China

December 2017
Bin Cai | Bin Peng

Intracranial artery stenosis (ICAS), a common cause of ischemic stroke, is a growing cause of concern in China. Recently, many epidemiological, etiological, pathophysiological, therapy, and diagnostic...

Main air pollutants and ventricular arrhythmias in patients with implantable cardioverter-defibrillators: A systematic review and meta-analysis

December 2017
Hong-Jie Yang | Xin Liu | Chuan Qu | Shao-Bo Shi | Jin-Jun Liang | Bo Yang

Previous studies of ambient air pollutants and ventricular arrhythmias in patients with implantable cardioverter-defibrillator (ICD) have yielded mixed results, and the association between air pollution...

Acute myocardial infarction caused by myocardial bridging alone confirmed by using intravascular ultrasonography

December 2017
Na-Qiong Wu | Mario Evora | U Po Lam | Man Fai Ip | Jian-Jun Li

Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis

December 2017
Chao Han | Xi-Kun Han | Fang-Chao Liu | Jian-Feng Huang

Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain...

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