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Most Downloaded Frontiers in Laboratory Medicine Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Molecular targeted therapy of cancer: The progress and future prospect

June 2017
Xing Ke | Lisong Shen

Cancer has become a major public health problem worldwide. Researches focus on the new approaches for cancer treatments that involve the specific targets of the cancer disease. The premise of targeted...

2. Synthesis of chitosan mediated silver nanoparticles (Ag NPs) for potential antimicrobial applications

March 2018
R. Kalaivani | M. Maruthupandy | T. Muneeswaran | A. Hameedha Beevi | M. Anand | C.M. Ramakritinan | A.K. Kumaraguru

•Synthesis of chitosan mediated silver nanoparticles (Ag NPs) using laser ablation method.•Characterization of synthesized Ag NPs was using UV, FTIR, XRD, AFM and TEM techniques.•Synthesized Ag NPs...

3. Release of cardiac troponin from healthy and damaged myocardium

September 2017
Alan H.B. Wu

Cardiac troponins T and I are proteins released into serum after cardiac injury, and are the standard biomarkers for patients presenting to the emergency department with a suspicion of acute myocardial...

4. Synthesis of chitosan nanoparticles by TPP and their potential mosquito larvicidal application

June 2018
M. Anand | P. Sathyapriya | M. Maruthupandy | A. Hameedha Beevi

Nowadays chitosan nanoparticles (CS NPs) have been extensively considered for biomedical applications. The purpose of this paper is to summarize the results of larvicidal activities of extracted chitosan...

5. The application of Student’s t-test in internal quality control of clinical laboratory

September 2017
Yang-chun Feng | Yan-chun Huang | Xiu-min Ma

James O. Westgard advised that the relation between internal quality control (IQC) and statistical methods, such as t-test, should be seriously considered. The results of IQC fully fit in the requirements...

6. Autophagy: A new target for the treatment of atherosclerosis

June 2018
Yan Sun | Xiu-ru Guan

Atherosclerosis remains one of the main causes of death in both developed and developing countries, leading to acute cardiovascular events and chronic injuries. Atherosclerosis is a multifactorial disease,...

7. Application of terahertz spectroscopy in biomolecule detection

Available online 6 June 2019
Liu Wei | Liu Yu | Huang Jiaoqi | Huang Guorong | Zhang Yang | Fu Weiling

Terahertz (THz = 1012 Hz) radiation has caused enormous widespread attention due to its use in biomedical sciences. The tremendous advances in THz instruments have made an impressive breakthrough in...

8. Detection of ESBL genes from ciprofloxacin resistant Gram negative bacteria isolated from urinary tract infections (UTIs)

March 2018
Govindan Rajivgandhi | Muthuchamy Maruthupandy | Govindan Ramachandran | Muthu Priyanga | Natesan Manoharan

Urinary tract infections (UTIs) are the most disregarded diseases in both developing and developed countries and accountable for one fourth of the health care related infections. Even though the women...

9. The pathogenesis of autoimmune hepatitis

March 2018
Mingxue Wang | Hua Zhang

Autoimmune hepatitis (AIH) is a liver inflammatory disease via induction of debris-like necrosis in the liver portal area, which is characterized by hypergammaglobulinemia and a variety of autoantibodies....

10. Graphene quantum dots in biomedical applications: Recent advances and future challenges

December 2017
Fei Chen | Weiyin Gao | Xiaopei Qiu | Hong Zhang | Lianhua Liu | Pu Liao | Weiling Fu | Yang Luo

Graphene quantum dots (GQDs)-based nanohybrid materials have gained great attention in multiple research applications, particularly in biomedical fields due to their unique physicochemical properties...

11. Advances of lncRNA in autoimmune diseases

June 2018
Jiajian Wang | Feng Wei | Haizhou Zhou

Long non-coding RNA (lncRNA) is a newly identified non-coding RNA with various regulatory functions. Recent evidence has shown how lncRNA affect the disease development at different degrees. Studies...

12. A digital PCR assay development to detect EGFR T790M mutation in NSCLC patients

September 2018
Ruifeng Zhou | Yiran Cai | Zhaoliang Li | Shuangye Shen | Mozhou Sha | Steven R. Head | Yan Wang

Epidermal growth factor receptor (EGFR) is a crucial factor in the development of non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitor (TKI) therapy requires a sensitive and accurate assay...

13. Using digital PCR to detect HER2 amplification in breast and gastric cancer patients

September 2018
Ruifeng Zhou | Peng Yuan | Lihua Zhang | Shuangye Shen | Zhaoliang Li | Yan Wang

HER2 amplification detection assays are widely used as companion diagnostic tools for Herceptin targeted therapy on Breast and Gastric cancer patients. Current tests approved for clinical use are in...

14. Accuracy of fasting plasma glucose and hemoglobin A1c testing for the early detection of diabetes: A pilot study

June 2017
John Kam-On Chung | Hang Xue | Eric Wing-Hang Pang | Daniel Chuen-Chu Tam

Diabetes, often referred as diabetes mellitus, describes a group of metabolic disorders characterized by chronic hyperglycaemia with disturbances of fat, carbohydrate and protein metabolism because...

15. A digital PCR based assay to detect all ALK fusion species

June 2018
Ruifeng Zhou | Yiran Cai | Shuangye Shen | Mozhou Sha | Zhaoliang Li | Steven R. Head | Yan Wang

Accurate detection of Anaplastic lymphoma kinase (ALK) fusion in lung cancer cells is essential to screen for patients suitable for targeted drug treatments such as crizotinib. ALK fusion involves multiple...

16. Using the VAP lipid panel for the detection, evaluation, and treatment of patients “at risk” for CAD

December 2017
Kenneth French | Yi Wang | Jianghua Jia | Yusheng Zhang

In the past several decades, multiple clinical trials have demonstrated the effects of dyslipidemia beyond low density lipoprotein cholesterol (LDL-C) on predicting risk for atherosclerosis and cardiovascular...

17. The analysis of the detection performance of nucleic acid testing and ELISA for HIV, HBV and HCB

December 2017
Wei Huang | Wei Wei | Xiao Tian Shi | Tianlun Jiang

To explore the clinical efficacy of Nucleic acid testing (NAT) in combination with Enzyme linked immunosorbent assay (ELISA)....

18. Laboratory diagnosis of antiphospholipid syndrome

September 2018
Chao Wang | Xiu-ru Guan

Antiphospholipid syndrome (APS) is an autoimmune disease with manifestations of recurrent thromboembolic events, unexplained miscarriage, and thrombocytopenia. Although the presence of one or more types...

19. Prevalence of hepatitis E virus infection among pregnant women in Zhenjiang, China

September 2018
Zhilian Rui | Lihua Jiang | Xiaochun Wang | Yan Yang | Ying Peng | Yu Ling | Wen Zhang | Xingli Fu | Chenglin Zhou | Shixing Yang | Quan Shen

Most hepatitis E virus (HEV) infections are mild or subclinical, however, the infections are characteristically associated with a high incidence of symptomatic presentation among pregnant women....

20. Applications of cerebrospinal miRNA in the detection and treatment of acute CNS injury

June 2018
Qi Yang | Qinghai Shi | Jianfeng Fu

MicroRNAs (miRNAs) are short-chain 20–24-nucleotide RNAs that are produced and processed from endogenous non-coding RNA (sncRNA). They act as a bridge between DNA, mRNAs, and proteins, induce epigenetic...

21. Research progress on anti-mullerian hormone clinical applications and immunoassay development

March 2018
Hui Sun | Huajie Mao | Jianhui Cai | Ya Zhao

Anti-mullerian hormone (AMH) is a member of the transforming growth factor-β (TGF-β) superfamily and is also known as mullerian inhibiting substance (MIS) due to its role in causing the regression of...

22. Expression and antibacterial activity of hybrid antimicrobial peptide cecropinA-thanatin in Pichia pastoris

March 2018
Zeqiang Liu | Mingxing Zhu | Xiangjun Chen | Guimao Yang | Tiantian Yang | Longmei Yu | Liyuan Hui | Xiuqing Wang

The hybrid peptide CA(1–7)-T(4–19) gene was designed according to the N-terminal 1–7 amino acid sequence of the antimicrobial peptide cecropinA (CA) and the N-terminal 4–19 amino acid sequence of thanatin...

23. Prognostic value of Bmi-1 oncoprotein expression in non-small cell lung cancer

September 2018
Dan Xiong | Yunlin Ye | Bohua Kuang | Hongmei Mo | Xiaoqing Xu | Qinquan Cai | Enyun Wang | Wensen Lu | Yanping Luo | Jiehong Wei | Xiuming Zhang

Background: In our prior study, Bmi-1 was elevated in non-small cell lung cancer (NSCLC) and took an important role in the early stage of progression. However, the clinical significance of Bmi-1 in...

24. p62/SQSTM1: A potential molecular target for treatment of atherosclerosis

June 2017
Xiao-fei Liang | Xiu-ru Guan

Atherosclerosis is a chronic inflammatory disease, and multiple signaling pathways participate in its pathophysiological process. It has been generally recognized that macrophage autophagy is involved...

25. Study on the immunity protection of 14-3-3–MPLA–liposome vaccine against cystic echinococcosis in mice

Available online 24 May 2019
ZongJi Li | Shuqing Ding | Yuan Li

The study aims to investigate the protective immunity against Echinococcus granulosus in mice immunized with14-3-3–MPLA–liposome vaccine. ICR (Institute of Cancer Research) mice were subcutaneously...

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