Special issue on mRNA synthesis, delivery and applications
Published 28 September, 2022
Introduction:
As a result of recent scientific discoveries made in response to the COVID-19 outbreak, messenger RNA (mRNA) research and development has been thrust into the public eye as a potentially game-changing disruptive technology. The interest in mRNA is driven by three essential parameters: safety, speed and effectiveness. However, the scientific community must still overcome difficulties to make the process of producing mRNA vaccines and therapies more effective and efficient. To reach the full potential of mRNA, it is vital to focus on key areas and strategies that can aid in the elimination of bottlenecks in this increasing market segment, resulting in a paradigm-shifting development in the biopharmaceutical industry and other fields. Cooperation, open conversation and a concerted effort will be required to pave the way for the mRNA industry's bright future.
Topics covered:
These will include, but not be limited to:
- Computational mRNA design
- mRNA synthesis
- DNA template preparation
- In vitro transcription
- mRNA degradation and stabilisation
- mRNA capping
- mRNA poly(A) tail
- Unnatural mRNA modification
- mRNA structure prediction
- Circular mRNA
- Novel mRNA structure
- mRNA storage
- Viral and non-viral vectors for mRNA delivery
- mRNA vaccine
- mRNA therapeutic development
- mRNA immunological mechanisms
- Industrial mRNA manufacturing
- mRNA formulation strategy
- mRNA safety
- Novel mRNA applications
Important deadlines:
- Submission deadline: 31 March 2023
- Publication date: upon acceptance
Submission instructions:
Please read the Guide for Authors before submitting. All articles should be submitted online; please select the special issue “mRNA synthesis, delivery and applications”.
Manuscripts will be reviewed and published on a first-come, first-served basis. Once all accepted manuscripts are published, they will be gathered together in this special issue.
Guest Editor:
- Yuan Lu, Tsinghua University, China. Email: yuanlu@mail.tsinghua.edu.cn