Special Issue on Smart Materials and Approaches for Soft and Hard Tissue Regeneration in the Oral and Maxillofacial Region

Published 16 February, 2021

This special issue will present key advances in smart biomaterials and stem cells in the head and neck region, particularly in the fields of smart materials and dental pulp stem cells, as well as devices and novel technologies for the regeneration of defected soft and hard tissue.

Soft and hard tissue defects may develop in the oral and maxillofacial region as a result of trauma, infection, severe tooth loss, pathological conditions or tumour resection. They are a common problem that impact a patient’s quality of life and can result in poor dietary intake, poor productivity and tremendous financial loss. Healing is a complex process that includes many biological cascades that regulate cellular proliferation, differentiation, as well as several pathways activating angiogenesis, chondrogenesis, osteogenesis, etc. These precisely-controlled mechanisms create new tissue and lead to complete rehabilitation of several soft and hard tissue defects. However, in some cases of trauma, pathological conditions, congenital problems and systemic health problems such as diabetes mellitus, the defects will reach or exceed the critical threshold for self-repair. In addition, some pathological conditions cause a reduction in the natural regenerative capacity of tissues. To address these problems, several tissue-engineering strategies have been developed which include smart materials, responsive delivery systems, and stem-cell based therapies. 

This special issue will feature recent advances in these tissue-engineering strategies, with a focus on oral and maxillofacial reconstructions.

Topics Covered:

  • The use of smart biomaterials, which are responsive to external stimuli (such as light, temperature, etc.) or internal stimuli (such as ion, glucose, enzyme, etc.)  for hard and soft tissue regeneration in the oral and maxillofacial region.
  • The use of stem cells, e.g., adipose-derived stem cells, dental pulp stem cells, etc. in the regeneration of oral and maxillofacial tissues.
  • Bio-fabrication and biofunctionalisation of scaffolds to create a biomimetic platform for regenerating soft and hard tissues.
  • Micro/nano systems for the controlled delivery of bioactive molecules (such as proteins, drugs and genes) to the progenitor cells for soft and hard tissue regeneration in the oral and maxillofacial region.
  • Multifunction systems to realise the special functions of antibacterial, antioxidant and vascularisation under the harsh ecological environment of the oral and maxillofacial region.
  • Experimental, pre-clinical and clinical studies on the applications of smart materials and novel technologies for treating oral diseases or defects.
  • Other relevant bioactive materials to improve the regeneration of soft and hard tissue in the oral and maxillofacial region.

Important Deadlines:

Submission deadline: 31 December 2021

Submission Instructions:

Please read the Guide for Authors before submitting. All articles should be submitted online; please select “tissue regeneration” on submission.

Guest Editors:

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