Special issue on engineering gene regulation

Gene expression and its regulation are central to the engineering of biological systems. Complex cellular phenotypes, ranging from optimised biosynthesis to robust responses to environmental stimuli, may only be achieved by precisely controlling both the levels and dynamics of gene expression in genetic circuits. The parts that form the basis of these circuits operate at the transcriptional, posttranscriptional, translational and/or even post-translational levels to control gene expression. Modelling, cell-free and systems biology approaches have also revolutionised our ability to rapidly prototype and identify optimal designs for diverse applications. In this special issue of Synthetic and Systems Biotechnology, we invite research articles and review perspectives on the discovery, engineering and prototyping of gene regulation mechanisms for diverse applications.

Topics covered:

These will include, but not be limited to:

• Transcription factor engineering and/or discovery
• CRISPRi/a approaches for controlling gene expression
• Promoter engineering and/or discovery
• RNA devices for controlling gene expression
• Engineering post-translational regulation
• Orthogonal translation systems
• Cell-free prototyping of genetic circuits
• Modelling of genetic circuits

Important deadlines:

• Submission deadline (for full papers): 31 August 2022
• Publication date: upon acceptance

Submission instructions:

Please read the Guide for Authors before submitting. All articles should be submitted online; please select the special issue “Engineering gene regulation”.

Manuscripts will be reviewed and published on a first-come, first-served basis. Once all accepted manuscripts are published, they will be gathered together in this special issue.

Guest Editors:

• Prof. Nicholas Sandoval, Tulane University, USA. Email: nsandova@tulane.edu
• Prof. Kevin Solomon, University of Delaware, USA. Email: kvs@udel.edu