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ISSN: 2590-2806

CreCENT: Creatinine and Chloride based Electrochemical Non-faradaic renal health mapping Technology

In this work, we propose a novel biosensing scheme to enable the stratification of kidney diseases based on severity and progression for timely triage and efficient management. Here, using Creatinine...

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In addition to early biomarkers, what else can be done with urine?

Biomarkers are measurable changes associated with physiological or pathophysiological processes in the body. Many types of biomarkers can accumulate in urine, which is not strictly subjected to homeostatic...

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Changes in the urine proteome in patients with advanced lung cancer after different drug treatments

Lung cancer is one of the most threatening diseases to human life and health because of its mortality. How to choose more efficient drugs and the appropriate timing of treatment for patients with advanced...

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A review on traditional natural compounds and conventional methods for the treatment of UTI

The intensity of the urinary tract infection (UTI), a recurrent infection that is common in coastal locations and that affects people of different ages, varies. One of the main bacteria that causes...

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A new HPLC-MS/MS method for urinary creatinine determination: Comparison study with Jaffè’s method

Urinary biomarkers are usually reported as a normalized ratio to creatinuria, a lack of correct creatinine determination lead to wrong final data. This study aimed to evaluate the Jaffè method accuracy,...

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Induced crystal formation in urine as an easily accessible indicator of tumor stage? – A translational explorative study

Urinary concentrations of metabolic products associated with neoplasms can change the supersaturation and thus alter the potential of crystal formation in urine. This study examines the ability of the...

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A facile strategy for comprehensive proteome analysis of urine using ultracentrifugation fractionation, solid-phase alkylation based sample preparation and liquid chromatography-mass spectrometry

In this work, a facile strategy with combination of ultracentrifugation fraction, solid-phase alkylation sample preparation and liquid chromatography-mass spectrometry (LC-MS) was developed to achieve...

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Urine; a new promising biological fluid to act as a non-invasive biomarker for different human diseases

Traditional disease diagnosis often involves invasive procedures like biopsies or blood draws, which are uncomfortable, costly, and carry risks. However, recent advancements in non-invasive biomarker...

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Commentary: Why have different key biomarkers been reported in the same types of samples from patients with identical diseases?

Accurate biomarkers are crucial for early disease detection and improved prognosis. However, the inconsistent reporting of different key biomarkers in the same types of samples from patients with identical...

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Urine biomarkers can outperform serum biomarkers in certain diseases

Urinary biomarkers offer a non-invasive and easily accessible means of assessing an individual's health and susceptibility to various diseases. Urine biomarkers have advantages in no need or mechanism...

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Perspectives in urine AD7c-NTP: A biomarker for Alzheimer's disease

Biomarkers are important for early diagnosis of Alzheimer's disease (AD) in routine clinical practice and research. Alzheimer-associated neuronal thread protein (AD7c-NTP) is a member of the “neuronal...

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The devil is in the detail

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Urine metabolome reveals candidate biomarkers for divergent residual feed intake in beef cattle

We analyzed the amine/phenol-metabolome of urine samples to identify urinary metabolic biomarkers associated with residual feed intake in beef cattle. A group of 56 crossbred growing beef steers (average...

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Hematuria as a possible clinical presentation in monkeypox

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Comparison laser anatomical endoscopic enucleation of the prostate (LAEEP) and transurethral resection of the prostate (TURP) in BPH treatment: A meta-analysis

Laser anatomical endoscopic enucleation of the prostate (LAEEP) is one of the alternative surgical procedures other than TURP for benign prostate hyperplasia (BPH). However, the consideration for clinical...

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Comments on: Huang S. et al. “Biofluid Biomarkers of Alzheimer's disease: Progress, problems, and perspectives.” Neuroscience Bulletin (2022)

This paper by Huang S., et al. has retrospectively described the recent progress in biomarkers based on the A-T-N-X framework, A-T-N respectively represents Amyloid-Tau-Neurodegeneration, X represents...

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Urine concentration in elderly women and men

The degree of urine concentration, which is of relevance to healthcare, is higher in middle-aged males than in females, but whether this difference remains in elderly hospital patients is unknown. Urine...

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Using one-to-many urine proteome comparisons to provide clues for fever of unknown origin

To provide diagnostic evidence and clues for patients with fever of unknown origin (FUO) through urine proteomics analysis....

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Comments on: Saenger T. et al. “Urinary Biomarkers for Orange Juice Consumption.” Molecular Nutrition & Food Research (2021)

This paper by Saenger T., et al. has suggested the potential biomarkers for orange juice consumption and addressed an approach to distinguish between low, medium, and high orange juice consumption....

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The start of diabetes insipidus?

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The potential of spot and overnight urine in the evaluating of proteinuria and electrolyte

Urine testing has been a primary standard clinical method for assessing proteinuria and electrolyte intake. The traditional 24 ​h urine collection method, despite its high accuracy, has some limitations...

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A matter of perspective—Cutting-edge technology-driven urine proteome in COVID-19

In a recent issue of Nature Communications, we highlighted in-depth urine proteomic research in which significant immunosuppression was revealed in early SARS-CoV-2- infected patients 1. The application...

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Urine proteome of COVID-19 patients

The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain...

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Urinary metabolomic and proteomic analyses in a mouse model of prostatic inflammation

Lower urinary tract symptoms (LUTS) are common among aging men. Since prostatic inflammation is one of its etiologies, it is plausible that urinary metabolite and protein biomarkers could be identified...

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