Digital twins for stroke prediction and management
Available online 2 April 2026
•Digital twins: dynamic computational replicas integrating multimodal patient data.•Patient-specific left atrial modelling stratifies AF-related embolic risk.•Imaging-informed cerebrovascular hemodynamics...
Association of pre-admission use of sartans and calcium channel antagonists with outcomes after spontaneous intracerebral hemorrhage: A retrospective cohort study
Available online 2 April 2026
Spontaneous intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high morbidity and mortality. Preclinical studies suggest that angiotensin II-type 1 receptor blockers such as sartans...
Oxidative stress in post-stroke neurorestoration: from mechanisms to therapy
Available online 1 April 2026
The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk
Available online 1 April 2026
Neuroinflammation is a convergent feature of neurodegenerative diseases, hemorrhagic and ischemic stroke, and spinal cord injury. Central to this process is the Toll-like receptor 4 (TLR4) and myeloid...
Dual-port robot-assistant visualized minimally invasive aspiration (RAVMIA) for evacuation of irregular basal ganglia hemorrhage: A technical note
Available online 31 March 2026
The surgical management of intracerebral hemorrhage (ICH) remains controversial. While minimally invasive endoscopic techniques have shown promise, recent trials have not demonstrated positive outcomes...
Effectiveness of clazosentan in aneurysmal subarachnoid hemorrhage: A 12-year multicenter real-world study
Available online 31 March 2026
Outcomes of aneurysmal subarachnoid hemorrhage (SAH) remain poor. This study aimed to investigate changes in outcomes before and after the introduction of an endothelin A receptor antagonist clazosentan...
Precision medicine for cerebral Haemorrhage: Integrating Neuromarkers, Therapeutics, and recovery pathways
Available online 9 March 2026
Application of “three-in-one” technique in spontaneous supratentorial intracerebral hemorrhage with cerebral herniation
Available online 5 February 2026
Spontaneous supratentorial intracerebral hemorrhage (SSICH) with cerebral herniation has extremely high mortality rate and poor prognosis. Rapid and sufficient decompression is of great significance...
Prognostic value of TC/HDL-C ratios in ischemic stroke: a multicenter observational study
Available online 3 February 2026
This study aimed to determine the relationship between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and adverse outcomes in patients with first-ever ischemic stroke...
Neural decoding for EEG-BCI: from conventional machine learning to deep learning models
Available online 12 January 2026
Brain–computer interfaces (BCIs) decode neural signals to support alternative communication for individuals with motor and speech impairments, including severe speech disorders. We review EEG-BCI decoding...
Comparison of single-channel EEG decoding performance in imagined speech tasks
Available online 5 January 2026
EEG-based imagined speech decoding technology offers a communication solution for patients with language impairments. However, existing research on English-language systems cannot be directly applied...
The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage
December 2025
The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...
Novel middle meningeal artery-targeted mini-craniotomy incision and technique for treatment of chronic subdural hematoma with membranes/septations – technical note and case series
December 2025
Subdural hematomas (SDH) requiring surgery are associated with significant morbidity in elderly patients. We describe a novel technique/incision for minimizing invasiveness and duration, minimizing...
The role of D-dimer in intracerebral haemorrhage outcomes
December 2025
Activation of the coagulation and fibrinolysis system is a significant factor in secondary brain injury following spontaneous intracerebral haemorrhage (ICH). However, the relationships between plasma...
Application and future directions of brain-computer interfaces in neurological disorders: Technological advances, clinical practices, and challenges
December 2025
Brain-Computer Interfaces (BCIs) represent an innovative frontier in technology, establishing a direct link between the brain and external devices. This rapidly evolving field is increasingly recognized...
Tongji Biobank: A High-Quality Repository Integrating Multi-Dimensional Biomedical Data
December 2025
With the advancement of biotechnology and computer technology, life sciences and medical data have grown rapidly, and research paradigms have undergone revolutionary changes. Biomedical and clinical...
IRRAflow active irrigation and drainage system: A glimpse into the future of cerebrospinal fluid shunts
December 2025
Chronic hydrocephalus after subarachnoid hemorrhage may become inevitable, necessitating a permanent cerebrospinal fluid shunt. We report a 40-year-old woman with SAH and a CHESS score of 6. We implemented...
Zero-shot multi-modal large language models v.s. supervised deep learning: A comparative analysis on CT-based intracranial hemorrhage subtyping
December 2025
Comparison of responses from six multi-modal large language models on a random case, which illustrates a fracture in the patient’s left skull due to trauma, with subdural hemorrhage (SDH) evident in...
Impact of pre-existing neuroendocrine tumors on brain tissue compliance following intracerebral hemorrhage in old spontaneously hypertensive rats
December 2025
Conditions associated with mass effect, such as intracranial tumors and hemorrhagic stroke (intracerebral hemorrhage; ICH), disrupt intracranial pressure (ICP) regulation by exhausting the brain’s compliance...
Targeting mitochondrial NOX4/ROS to prevent hyperglycemia-induced hemorrhagic transformation after mechanical thrombectomy in acute ischemic stroke
December 2025
This study examines whether mitochondrial NOX4 (mtNOX4) plays a crucial role in hemorrhagic transformation (HT) after mechanical thrombectomy (MT) in acute ischemic stroke (AIS)....
Robot-Assisted surgery for primary brainstem Hemorrhage: A systematic review and Meta-Analysis
December 2025
This systematic review and meta-analysis evaluated the efficacy and safety of robot-assisted surgery for primary brainstem hemorrhage (PBSH)....
A study on the relationship between the severity of leukoaraiosis and post-thrombolytic hemorrhage in acute cerebral infarction thrombolysis patients
Available online 30 December 2025
This study aims to investigate the relationship between the severity of leukoaraiosis and post-thrombolytic cerebral hemorrhage in patients with acute cerebral infarction undergoing thrombolytic therapy....
MiRNAs to predict clinical outcome in intracerebral hemorrhage: a systematic review
Available online 22 November 2025
To summarize, the involvement of miRNAs in predicting the progression of spontaneous intracerebral hemorrhage (sICH) correlated with the clinical outcome under systematic, structured review....
ASL evaluation of cerebral microcirculation after coil embolization for aneurysmal subarachnoid hemorrhage: effects of clazosentan
Available online 19 November 2025
To evaluate the effect of continuous intravenous clazosentan on cerebral microcirculation after coil embolization for aneurysmal subarachnoid hemorrhage (aSAH) using arterial spin labeling (ASL) MR...
Research progress on risk stratification warning models for early hematoma expansion and poor outcome in intracerebral hemorrhage: A narrative review
Available online 14 November 2025
This review explores recent advances in risk stratification systems for early hematoma expansion (HE), focusing on predictive models using CTA, NCCT, radiomics, and artificial intelligence to enhance...
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