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Most Downloaded Brain Hemorrhages Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. The blood brain barrier in cerebral ischemic injury – Disruption and repair

March 2020
Wenting Zhang | Ling Zhu | Chengrui An | Rongrong Wang | Liqun Yang | Weifeng Yu | Peiying Li | Yanqin Gao

With the emergence of novel technologies and ground breaking concepts in BBB basic research in the past decades, the researchers’ attention on the critical role of blood brain barrier (BBB) integrity...

2. Anticoagulant-associated intracerebral hemorrhage

March 2020
Andrea Morotti | Joshua N. Goldstein

Intracerebral hemorrhage (ICH) is the most dangerous complication of oral anticoagulant treatment (OAT). Up to half of patients with OAT-related ICH experience early clinical deterioration due to active...

3. Collaterals in ischemic stroke

March 2020
Konark Malhotra | David S. Liebeskind

Collateral flow plays a pivotal role, both in acute and chronic phases of cerebral ischemia. Recruitment of these redundant vascular networks maintains cerebral blood flow to ischemic areas, while primary...

4. Artificial intelligence: The dawn of a new era for cutting-edge technology based diagnosis and treatment for stroke

March 2020
Yang Ma | Ping Zhang | Yingxin Tang | Chao Pan | Gaigai Li | Na Liu | Yang Hu | Zhouping Tang

Stroke is the second leading cause of death worldwide. Therefore, research on prevention and treatment for stroke has great significance. In recent years, the development of artificial intelligence...

5. Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke

March 2020
Sydney Corey | Brooke Bonsack | Matt Heyck | Alex Shear | Nadia Sadanandan | Henry Zhang | Cesar V. Borlongan

Hemorrhagic stroke is a global health crisis plagued by neuroinflammation in the acute and chronic phases. Neuroinflammation approximates secondary cell death, which in turn robustly contributes to...

6. Behavioral assessment of post-stroke depression and anxiety in rodents

June 2020
Danyang Chen | Junmin Wang | Yinpei Xing | Peijun Jia | Yuheng Zhang | Jiarui Wang | Honglei Ren | Anh Le | Xuemei Chen | Jian Wang

In this review, we compare behavioral protocols (e.g., equipment specification, test duration), evaluation indexes, application characteristics, and advantages and disadvantages of six tests used to...

7. Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke

June 2020
Yu Hasegawa | Cao Cheng | Kenyu Hayashi | Yushin Takemoto | Shokei Kim-Mitsuyama

Stroke is a primary cause of death and a leading cause of disability throughout the world. Although researchers have long studied ways for improving mortality and morbidity, few effective treatments...

8. The effectiveness of hyperbaric oxygen modalities against vascular component of traumatic brain injury

June 2020
Robert P. Ostrowski | Emanuela Pucko | Ewa Matyja

Intracranial bleeding occurs in a substantial percentage of patients with neurotrauma and may gravely impact clinical outcomes. Hyperbaric oxygen (HBO) has been tested for traumatic brain injury (TBI),...

9. Imaging markers in acute phase of stroke: Implications for prognosis

March 2020
Ying Zhou | Sheng Zhang | Min Lou

Currently, various methods for inspecting ischemic stroke are available, especially the imaging techniques, which play an important role in assisting diagnosis and prognostication of ischemic stroke....

10. Temporal evolution of heme oxygenase-1 expression in reactive astrocytes and microglia in response to traumatic brain injury

March 2020
Alexander Morita | Amandine Jullienne | Arjang Salehi | Mary Hamer | Emon Javadi | Yasir Alsarraj | Jiping Tang | John H. Zhang | William J. Pearce | André Obenaus

Heme oxygenase-1 (HO-1) is an inducible enzyme that catabolizes heme into biliverdin (which is converted to bilirubin), carbon monoxide, and free iron. HO-1 and its downstream molecules have antioxidant...

11. Mechanisms and potential therapeutic targets for spontaneous intracerebral hemorrhage

June 2020
Wei Hua | Xuemei Chen | Junmin Wang | Weidong Zang | Chao Jiang | Honglei Ren | Michael Hong | Jiarui Wang | He Wu | Jian Wang

In this review paper, the most recent research on intracerebral hemorrhage (ICH) is summarized and novelperspectives are offered on the pathomechanisms of ICH. These underlying pathomechanisms of ICH...

12. Intracerebral hemorrhage in translational research

March 2020
Ruiyi Zhang | Qian Bai | Yang Liu | Yan Zhang | Zhaofu Sheng | Mengzhou Xue | V. Wee Yong

Intracerebral hemorrhage (ICH) is a serious stroke subtype with high morbidity and mortality. The prognosis of ICH is poor. In recent years, there have been many studies on how to improve the prognosis...

13. Effects of apple polyphenols on oxidative stress and cerebral vasospasm after subarachnoid hemorrhage in a rabbit double hemorrhage model

March 2020
Masato Naraoka | Yuchen Li | Takeshi Katagai | Hiroki Ohkuma

Subarachnoid hemorrhage (SAH) is almost always caused by ruptured cerebral aneurysms, and the most serious complication after SAH is cerebral vasospasm. Oxidative stress due to free radicals released...

14. Imaging predictors for hematoma expansion in patients with intracerebral hemorrhage: A current review

June 2020
Xin-Ni Lv | Qi Li

Spontaneous intracerebral hemorrhage (ICH) is the common subtype of stroke and has a higher risk of morbidity and mortality than ischemic stroke. Early enlargement of the hematoma has been identified...

15. Double porous media modeling in computational fluid dynamics for hemodynamics of stent-assisted coiling of intracranial aneurysms: A technical case report

March 2020
Masanori Tsuji | Fujimaro Ishida | Tomoyuki Kishimoto | Kazuhiro Furukawa | Yoichi Miura | Masato Shiba | Takanori Sano | Keiji Fukazawa | Katsuhiro Tanaka | Hiroshi Tanemura | Yasuyuki Umeda | Ryuta Yasuda | Shinichi Shimosaka | Hidenori Suzuki

Endovascular therapy is developing, but not all aneurysms are completely obliterated even by using the techniques such as stent-assisted coiling or a flow diverter. To predict the aneurysm-occlusion...

16. Effects of the treatment timing of minimally invasive surgery and urokinase dosage on perihaematomal oedema in intracerebral hemorrhage evacuation

March 2020
Yang Ma | Ping Zhang | Yingxin Tang | Xiaohua Yang | Zhouping Tang

The main aims of the study were to explore the correlation between different times of a minimally invasive operation and perihaematomal oedema properties in patients with cerebral hemorrhage, to identify...

17. Predictors of risk of intracerebral hemorrhage after intracranial artery intervention in intracranial atherosclerotic stenosis patients

March 2020
Liang Liu | Jie Li | Qing-Wu Yang

To investigate the relationship between clinical characters of intracranial atherosclerotic stenosis patients and occurrence of cerebral hemorrhage after intracranial artery intervention. Clinical data...

18. Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

March 2020
Zhe Kang Law | Michael Desborough | Kamini Rakkar | Philip M. Bath | Ulvi Bayraktutan | Nikola Sprigg

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH...

19. Up-regulation of PPARγ, Nrf2 and HO-1 in microglia activated by thrombin

June 2020
Hang Hang | Likun Wang | Guofeng Wu | Siying Ren

To explore the molecular mechanism involved in secondary brain damage caused by intracerebral hemorrhage (ICH), we activated microglia by thrombin, to observe the changes of peroxisome proliferator-activated...

20. Comparison of transradial and transfemoral cerebral angiography

March 2020
M.D. Liu | Gai Y.T.

To compare the feasibility, safety and effectiveness of transradial and transfemoral artery puncture cerebral angiography....

21. Fractalkine/CX3CR1 pathway is neuroprotective in intracerebral hemorrhage through facilitating the expression of TGF-β1

Available online 10 July 2020
Hai-Han Yu | Gai-Gai Li | Ying-Xin Tang | Shuang Bai | Chao Pan | Zhou-Ping Tang

Pronounced inflammation after intracerebral hemorrhage (ICH) contributes to secondary brain injury, which seriously affects the prognosis of ICH patients. Fractalkine (FKN)/CX3CR1 pathway may play an...

22. Classification mechanism and clinical analysis of perihematomal edema in intracerebral hemorrhage

Available online 10 July 2020
Shuhua Xie | Zhengfang Qin | Xiaoping Yin

The classification and mechanism of perihematomal edema in cerebral hemorrhage are complicated. The edema theory in different periods needs to be unified due to various reasons. Secondary perihematomal...

23. Scanning electron microscopy analysis of incidence and growth pattern of experimentally induced intracranial aneurysms in rat model

Available online 22 July 2020
Lucia Schwyzer | Serge Marbacher | Javier Fandino | Aaron S. Dumont

Experimental animal models are most valuable to study the initiation and growth of cerebral aneurysms. The aim of our study is to analyze the time course, incidence, location and growth pattern of intracranial...

24. Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage

Available online 25 July 2020
Guangyu Guo | Wenliang Guo | Yangyang Feng | Hong Deng | Ping Zhang | Yingxin Tang | Guofeng Wu | Qi Li | Chao Pan | Zhouping Tang

Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate...

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