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Most Downloaded Translational Medicine of Aging Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Therapeutic potential of boosting NAD+ in aging and age-related diseases

January 2018
Yahyah Aman | Yumin Qiu | Jun Tao | Evandro F. Fang

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging...

2. Amino acids in the regulation of aging and aging-related diseases

Clare-Ann Canfield | Patrick C. Bradshaw

Amino acids are the building blocks of protein, but also play important cellular signaling roles. The mechanisms through which altered levels of many amino acids are sensed and the signals transmitted...

3. Senescence in aging and disorders of the central nervous system

Barbara L. Swenson | Charlton F. Meyer | Tyler J. Bussian | Darren J. Baker

Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...

4. RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

Matt Kaeberlein

The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...

5. Automation of C. elegans lifespan measurement

Daniel P. Felker | Christine E. Robbins | Mark A. McCormick

Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...

6. Genome instability and aging: Cause or effect?

October 2017
Jan Vijg | Cristina Montagna

Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal...

7. A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease

Emelyne Teo | Soon Yew John Lim | Sheng Fong | Anis Larbi | Graham D. Wright | Nicholas Tolwinski | Jan Gruber

Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...

8. Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans

Eun Ji E. Kim | Seung-Jae V. Lee

Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs...

9. Nutrition, sarcopenia and frailty: An Asian perspective

Jean Woo | Sherlin Ong | Ruth Chan | Liz Li | Jianqin Sun | Yoke Mun Chan | Shiou-Liang Wee | Nghiem Nguyet Thu | Pham Thang | Siti Setiati | Yi-Chen Huang | Mark L. Wahlqvist | Lisette CPGM. de Groot

Despite a growing body of evidence that nutrition plays a key role in the pathophysiology, prevention and intervention programs of frailty and sarcopenia, as well as in promoting brain health, the awareness...

10. Remodeling of the H3 nucleosomal landscape during mouse aging

Yilin Chen | Juan I. Bravo | Jyung Mean Son | Changhan Lee | Bérénice A. Benayoun

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and deregulation of gene expression correlates with aging. A key...

11. Alternative splicing in aging and age-related diseases

October 2017
Huan Li | Ziyue Wang | Tianyi Ma | Gang Wei | Ting Ni

Alternative splicing (AS) of mRNA generates multiple protein isoforms from a single gene. This greatly expands proteome diversity and plays important roles in most biological processes. Global changes...

12. Translational geroscience: A new paradigm for 21st century medicine

October 2017
Matt Kaeberlein

Advances in geroscience are allowing scientists and clinicians, for the first time, to consider interventions aimed at directly targeting the hallmarks of aging. Unlike disease-specific approaches,...

13. Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

Available online 12 September 2019
Richard O'Laughlin | Meng Jin | Yang Li | Lorraine Pillus | Lev S. Tsimring | Jeff Hasty | Nan Hao

Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative...

14. Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism

Gulperi Yalcin | Cheol-Koo Lee

Extension of lifespan and amelioration of aging-associated phenotypes have been targets of many studies. Some of the established methods of increasing lifespan including dietary restriction and genetic...

15. Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

Shin-Hae Lee | Kyung-Jin Min

Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable...

16. Nanocarriers targeting senescent cells

Daniel Muñoz-Espín

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological...

17. Hypothesis: Plant stem cells hold the key to extreme longevity

Paul P. Dijkwel | Alvina G. Lai

Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not...

18. Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals

Hou-Ling Wang | Hongwei Guo | Zhonghai Li

Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention...

19. Advances in pharmacological interventions of aging in mice

Minxian Qian | Baohua Liu

The remarkable breakthroughs in aging research pave the way allowing us to explore potential interventions to slow down aging process, and more importantly, to improve healthiness. Multiple approaches,...

20. Role of the circadian clock in fine-tuning the process of leaf senescence in plants

Hyunmin Kim | Sunghyun Hong

Leaf senescence is a developmental process and a critical evolutionary strategy for fitness in plants, involving highly organized regulatory mechanisms. Many environmental signals as well as internal...

21. A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Takashi K. Ito | Tomohito Sato | Akio Hakamata | Yuki Onoda | Shumpei Sato | Fumiyoshi Yamazaki | Makoto Horikawa | Yutaka Takahashi | Takuya Kitamoto | Masako Suzuki | Shinya Uchida | Keiichi Odagiri | Mitsutoshi Setou

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...

22. An inexpensive microscopy system for microfluidic studies in budding yeast

Kenneth L. Chen | Toby N. Ven | Matthew M. Crane | Dexter E. Chen | Yen-Chi Feng | Nozomi Suzuki | Adam E. Russell | Diogo de Moraes | Matt Kaeberlein

Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high...

23. Alcohol and aging: From epidemiology to mechanism

October 2017
Stuart S. Adamson | Lear E. Brace | Brian K. Kennedy

Alcohol is one of the most widely encountered drugs in the world and is credited with a wealth of health interactions. Light to moderate regular consumption (14–28 g daily) can promote heart health,...

24. The functions of sarcopenia related myokines

January 2018
Lili Han | Si Wu | Ping Hu

Skeletal muscle is not only responsible for locomotion, but also a major metabolism and endocrine organ. Skeletal muscle produces several secreted factors to regulate the microenvironment of both muscle...

25. Computational tools for geroscience

Joseph C.P. Kruempel | Marshall B. Howington | Scott F. Leiser

The rapid progress of the past three decades has led the geroscience field near a point where human interventions in aging are plausible. Advances across scientific areas, such as high throughput “-omics”...

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