Amoxicillin and cotrimoxazole-driven dysbiosis disrupted blood cell levels, cytokine balance and induced oxido-nitrosative stress in young mice
November 2026
Amoxicillin and cotrimoxazole are among the most frequently prescribed antibiotics, yet their impact on gut microbiota and systemic physiology, particularly during early life, remains a critical concern....
An in-depth exploration of CNN-based deep learning models in cervical carcinoma analysis
November 2026
Cervical cancer has an extreme effect on women's health worldwide, recognized as the 4th most significant contributor to cancer fatalities among female. World Health Organization (WHO) states that there...
In silico screening of tripeptide inhibitors reveals potential lead compounds for targeting zika virus NS2B-NS3 protease
November 2026
ZIKV is a public health threat causing neurological complications such as microcephaly and Guillain-Barre syndrome, with the additional risk of sexual transmission. The absence of FDA-approved drugs...
Methanol extract of Smritisagara Rasa attenuates neurobehavior, neurochemical and stress indicators in rotenone-induced Drosophila model of Parkinson's disease
November 2026
Smritisagara Rasa (SSR), a traditional Ayurvedic herbo-mineral formulation, has long been prescribed for the treatment of Parkinson's disease (PD) since ancient times. Nevertheless, the underlying molecular...
Exploring the potential of IP-10 and sCD14 as inflammatory biomarkers in HIV–TB co-infection: a systematic review
November 2026
Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are major global health challenges, especially in sub-Saharan Africa and Southeast Asia, where their co-infection greatly increases illness and...
Mapping autophagy-lncRNA co-expression networks in early ovarian carcinoma by stage-resolved transcriptomic modelling
November 2026
Early-stage ovarian carcinoma exhibits heterogeneous molecular programming that influences tumor progression and therapeutic vulnerability. Using RNA-seq data from 96 tumors (GSE101108), we developed...
Evaluation of toxicity and antioxidant activities of various crude extracts of leaves and stems of Zygophyllumsimplex
2025
Zygophyllum simplex (Z. simplex) is a plant that has been used for a long time for the treatment of human diseases. Therefore, this present research study aims to prepare various plant extracts and...
Etiological connections between initial COVID-19 and two rare infectious diseases
2025
The origin of COVID-19 remains unclear despite extensive research. Theoretical models can simplify complex epigenetic landscapes by reducing vast methylation sites into manageable sets, revealing fundamental...
Unraveling ankylosing spondylitis: Exploring the genetic and immunological factors and latest treatment innovations
2025
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints. Gut microbiota significantly affects ankylosing spondylitis (AS) pathophysiology....
Bringing lab to the field: Exploring innovations in point-of-care diagnostics for the rapid detection and management of tropical diseases in resource-limited settings
2025
Tropical diseases present major health challenges in regions with limited resources, where access to advanced laboratory facilities is often scarce. This study explores the innovative techniques emerging...
Application of Generative Adversarial Networks on RNASeq data to uncover COVID-19 severity biomarkers
2025
The COVID-19 pandemic has highlighted the need for reliable biomarkers to predict disease severity and guide treatment strategies. However, the analysis of RNASeq data for biomarker discovery using...
MiRNA based target identification of TNFα gene in nephrotic syndrome
2025
Nephrotic syndrome (NS) can be caused by various underlying kidney conditions. In most cases, the exact cause of NS is unknown, although it may be related to the body's immune system malfunctioning....
Genomic analysis identifies an incipient signature to forecast imatinib resistance before start of treatment in patients with chronic myeloid leukemia
2025
The unprecedented success of tyrosine kinase inhibitor (TKI), imatinib, to induce remission in 86 % of chronic phase (CP) patients of chronic myeloid leukemia (CML) is undermined by drug resistance....
Clinical features and predictive model for invasive pulmonary fungal infections in hematologic disorders
2025
This study was to investigate the clinical features of hematological disorders complicated by invasive pulmonary fungal infections and identify factors affecting treatment outcomes, with the aim of...
A mini review: Role of novel biomarker for kidney disease of future study
2025
In the world, kidney disease is most common cause of death. Primary care physicians must conduct appropriate diagnosis, and management in order to avoid detrimental consequences linked to death as well...
Procalcitonin and C-reactive protein as alternative salivary biomarkers in infection and inflammatory diseases detection and patient care: A scoping review
2025
In ambulatory and hospital settings, inflammatory diseases stand a significant challenge for both patients and clinicians. These conditions, often serve as precursors to sepsis, necessitate effective...
Biomarkers in immunology: Their impact on immune function and response
2025
The immune system is a complex network of organs, tissues, and cells that plays a critical role in defending the body against life-threatening diseases such as infections, cancer, Alzheimer's, and Crohn's...
CAR-T and nanotechnology: A comparative Perspective on autoimmune disease and cancer
2025
Nanotechnology has emerged as a key transformative force in upgrading Chimeric Antigen Receptor T-cell (CAR-T) from generation to generation in cancer and autoimmune treatment. Nanotechnology-aided...
Investigations of solid waste biosorbents for eliminations of total hardness from water: An experimental study of conversion of waste into valuable products
2025
Hard water is a serious problem in the village areas. Alkaline hardness can cause eye pain, respiratory tract collapse, liver difficulties, and skin concerns. Human biological hardness after the extreme...
Urine PD-L1 as a non-invasive biomarker for immune checkpoint inhibitor (ICI) therapy in bladder cancer
2025
Bladder cancer (BCa) is a common urological malignancy with a high recurrence rate, often within 2 years of initial diagnosis and treatment. Due to this high recurrence, near all patients require cystoscopic...
Machine learning-driven discovery of anoikis-related biomarkers in Adult T-Cell Leukemia/Lymphoma subtypes
2025
Adult T-Cell Leukemia/Lymphoma (ATLL) is a malignancy that arises from T-cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1). The disease is characterized by uncontrolled proliferation...
Implementation of a disease trigger prediction model using AIML for early diagnosis of epilepsy
2025
Epilepsy is one of the most prevalent neurological disorders that negatively impacts patients' quality of life and poses a severe health risk. It is often characterized by recurrent brain seizures....
Decoding inflammatory signaling networks: From molecular mechanisms to therapeutic targets
2025
This review aims to provide a comprehensive overview of inflammatory signalling pathways and their pharmacological significance in human health and disease. Inflammation signifies a basic biological...
The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease
2025
Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether...
Lung-brain axis-generated inflammatory biomarkers in traumatic brain injury and acute respiratory distress syndrome: Role of mechanical ventilation/stress
2025
The unmet need for effective therapeutic strategies to address the bi-directional perturbation of the lung-brain axis following traumatic brain injury (TBI) or associated with Acute Lung Injury/Acute...