Long non-coding RNAs in humans: Classification, genomic organization and function
April 2025
Long non-coding RNAs (lncRNAs) regulate numerous biological functions in animals. Despite recent advances in lncRNA research, their structural and functional annotation and classification remain an...
The emerging role of miRNAs in biological aging and age-related diseases
August 2025
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes....
Recent advances in the development and clinical application of miRNAs in infectious diseases
February 2025
In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression,...
Small RNA sequencing in individually selected sperm: Biomarkers for male subfertility and predictors of pregnancy success
February 2026
Sperm quality defined by motility and morphology has critical implications for fertility and pregnancy outcomes. Small RNAs, including microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), play regulatory...
Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response
February 2025
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs),...
Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine
December 2024
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs),...
Long non-coding RNAs: Mechanism of action and functional utility
October 2016
Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance
June 2024
Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma...
RNA and liquid-liquid phase separation
June 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...
Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker
December 2025
To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker...
The progress of m6A methylation-regulated non-coding RNAs in osteogenic differentiation and osteoporosis
April 2026
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic RNA, and has increasingly been recognized as a critical regulator of gene expression at both the transcriptional and...
Non-coding RNAs in congenital heart disease and placental development: Bridging molecular mechanisms to clinical biomarkers and therapies
February 2026
Non-coding RNAs (ncRNAs) have emerged as pivotal regulators of gene expression, orchestrating embryonic development and disease pathogenesis. This review synthesizes current knowledge on the origin,...
Integrative analysis of tissue and circulating miRNAs as biomarkers for progression and survival in hepatocellular carcinoma
February 2026
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited biomarkers available for early diagnosis and risk stratification. In this study, we performed an integrative...
MiR-21 modulates P.g-LPS induced apoptosis and inflammatory response in HUVECs via NF-κB/iNOS/NO pathway by targeting PDCD4
February 2026
Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), a key virulence factor in periodontitis, contributes to systemic vascular diseases, notably atherosclerosis. MicroRNA-21 (miR-21), a critical post-transcriptional...
New mechanism of LncRNA: In addition to act as a ceRNA
December 2024
Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals...
miRNA-195-5p modulates cell proliferation and stemness by targeting the Wnt signalling network in breast cancer
December 2025
Cancer stem cells (CSCs) are a specific subpopulation of cells within the tumour characterised by self-renewal, proliferation and tumorigenic potential. Heterogeneity in the CSCs population and their...
Small non-coding RNAs as regulators of structural evolution and carcinogenesis
June 2017
Small non-coding RNAs (sncRNAs) are part of non-coding oligonucleotide regulators with wide physiologic and morphologic functions. They control genetic programing of cells, and may modulate processes...
Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease
April 2025
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate...
Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system
February 2025
Recently, the various regulative functions of long non-coding RNAs (LncRNAs) have been well determined. Recently, the vital role of LncRNAs as gene regulators has been identified in the immune system,...
The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs
June 2019
Virus-induced cellular genetic modifications result in the development of many human cancers....
Noncoding RNAs are indispensable architects and regulators of biomolecular condensates
June 2026
Liquid-liquid phase separation (LLPS) is a biophysical mechanism by which certain biomolecules demix from the cytosol or nucleoplasm to form membraneless organelles. These droplet-like assemblies are...
NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?
December 2018
Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...
Development of a microRNA-Based age estimation model using whole-blood microRNA expression profiling
June 2025
Age estimation is a critical aspect of human identification. Traditional methods, reliant on morphological examinations, are often suitable for living subjects. However, there are relatively few studies...
Circular RNA MALAT1 as a potential target for antimetastatic therapy
April 2026
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) located in the nucleus that is involved in the regulation of gene expression and alternative splicing...
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance
February 2026
Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribute...