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Recent Non-coding RNA Research Articles

Recently published articles from Non-coding RNA Research.

MicroRNA-486-5p and MicroRNA-486-3p: Multifaceted Pleiotropic Mediators in Oncological and Non-Oncological Conditions

Available online 9 January 2020
Aisha M. ElKhouly | R.A. Youness | M.Z. Gad

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration...

Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome

December 2019
Zainularifeen Abduljaleel | Mohammad Athar | Faisal A. Al-Allaf | Saied Al-Dehlawi | Jose R. Vazquez

The human gene MUTYH codes for a DNA glycosylase involved in the repair of oxidative DNA damage. Faulty MUTYH protein activity causes the accumulation of G→T transversions due to unrepaired 8-oxoG:A...

Identification of novel microRNAs and their targets in Chlorophytum borivilianum by small RNA and degradome sequencing

December 2019
Monika Kajal | Nishant Kaushal | Ravneet kaur | Kashmir Singh

Plant specific miRNAs (Novel miRNAs) are well known to perform distinctive functions in biological processes. Identification of new miRNAs is necessary to understand their gene regulation. Degradome...

Potential physiological roles of the 31/32-nucleotide Y4-RNA fragment in human plasma

December 2019
Sho Ninomiya | Tatsuya Ishikawa | Masayuki Takahashi | Mineaki Seki | Masayuki Nashimoto

The 31- and 32-nt 5′-fragments of Y4-RNA (Y4RNAfr) exist abundantly in human plasma. The Y4RNAfr can function as 5′-half-tRNA-type sgRNA for tRNase ZL, although we do not know yet what its physiological...

Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways

December 2019
Gabriel Pisani | Byron Baron

The nucleus is an essential hub for the regulation of gene expression in both spatial and temporal contexts. The complexity required to manage such a feat has resulted in the evolution of multiple sub-structures...

Comprehensive structure-function analysis of causative variants in retinal pigment epithelium specific 65 kDa protein associated Leber Congenital Amaurosis

December 2019
Zainularifeen Abduljaleel

A recent study published to screen RPE65 in 187 families with Leber Congenital Amaurosis (LCA) by Zilin Zhong in 2019. There are seven novel variants were identified in RPE65, which was associated with...

Unravelling the role of long non-coding RNA - LINC01087 in Breast cancer

Available online 24 December 2019
Rashmi Tripathi | Imlimaong Aier | Pavan Chakraborty | Pritish Kumar Varadwaj

Apoptosis is a ‘programmed fate’ of all cells participating in diverse physiological and pathological conditions. The role of critical regulators and their involvement in this complex multi-stage process...

The 31-nucleotide Y4-RNA fragment in plasma is a potential novel biomarker

Available online 17 December 2019
Tatsuya Ishikawa | Arisa Haino | Mineaki Seki | Taro Kurihara | Takayuki Hirose | Yosuke Imai | Takuro Ishiguro | Takaaki Chou | Muneatsu Toshima | Hiroshi Terada | Masayuki Nashimoto

The 31- and 32-nt 5′-fragment of Y4-RNA (Y4RNAfr) exists abundantly in human peripheral blood plasma. Although physiological roles of the plasma Y4RNAfr are not well established, its potential utility...

Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation

September 2019
Zainularifeen Abduljaleel

Oxidative damaged DNA base lesions are repaired through human 8-oxoguanine DNA glycosylase gene (hOGG1) mediated pathways. A recent report based on the meta-analysis has suggested that the DNA Repair...

Non-coding RNAs, a real Next-Gen Class of Biomarkers?

September 2019
Chiara Borga | Syed M. Meeran | Matteo Fassan

Neurodegeneration: The emerging non-coding connections

September 2019
Dipen Rajgor | Emanuele Buratti

Current role of non-coding RNAs in the clinical setting

September 2019
Caterina Vicentini | Francesca Galuppini | Vincenzo Corbo | Matteo Fassan

Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and...

A novel enhancer RNA, Hmrhl, positively regulates its host gene, phkb, in chronic myelogenous leukemia

September 2019
Roshan Fatima | Subhendu Roy Choudhury | Divya T.R | Utsa Bhaduri | M.R.S. Rao

Noncoding RNAs are increasingly being accredited with key roles in gene regulation during development and disease. Here we report the discovery and characterization of a novel long noncoding RNA, Hmrhl,...

On a stake-out: Mycobacterial small RNA identification and regulation

September 2019
Sagarika Taneja | Tanmay Dutta

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their survival in the...

Non-coding RNA regulation in reproduction: Their potential use as biomarkers

June 2019
Vanesa Robles | David G. Valcarce | Marta F. Riesco

Non-coding RNAs (ncRNAs) are crucial regulatory elements in most biological processes and reproduction is also controlled by them. The different types of ncRNAs, as well as the high complexity of these...

The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs

June 2019
Oxana V. Klimenko | Alexey Sidorov

Virus-induced cellular genetic modifications result in the development of many human cancers....

Dietary non-coding RNAs from plants: Fairy tale or treasure?

June 2019
Gopinath M. Sundaram

The past two decades have witnessed soaring interest in the field of non-coding RNAs, largely attributed by its regulatory role in controlling two third of human transcriptional output. Though, there...

Long non-coding RNAs in cancer

June 2019
Mi-Young Kim

C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks

June 2019
Stefan Stamm | J. Stephen Lodmell

C/D box snoRNAs (SNORDs) are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate...

Thank you note

March 2019

Long non-coding RNAs: Functional regulatory players in breast cancer

March 2019
Rana Ahmed Youness | Mohamed Zakaria Gad

Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional...

miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

March 2019
Valérie Metzinger-Le Meuth | Laurent Metzinger

microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded...

Circular RNA expression and function in the brain

March 2019
Shobana Sekar | Winnie S. Liang

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for...

Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics

March 2019
Elisa De Paola | Veronica Verdile | Maria Paola Paronetto

In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases....

Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development

December 2018
Vanessa Zammit | Mark R. Brincat | Viktor Cassar | Yves Muscat-Baron | Duncan Ayers | Byron Baron

Mesenchymal Stem Cells (MSCs) are widely used in therapeutic applications. Their plasticity and predisposition to differentiate into a variety of cell types, including those of the neuronal lineage,...

NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

Long non coding RNAs and ALS: Still much to do

December 2018
Stella Gagliardi | Cecilia Pandini | Maria Garofalo | Matteo Bordoni | Orietta Pansarasa | Cristina Cereda

Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated...

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma

December 2018
Bernhard Biersack

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The...

LONG-NONCODING RNAs in gastroesophageal cancers

December 2018
Giuseppe Nicolò Fanelli | Pierluigi Gasparini | Irene Coati | Ri Cui | Hubert Pakula | Basudev Chowdhury | Nicola Valeri | Fotios Loupakis | Juozas Kupcinskas | Rocco Cappellesso | Matteo Fassan

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates....

Non-coding RNA influences in dementia

December 2018
Duncan Ayers | Charles Scerri

Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other...

Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

December 2018
Andrew G.L. Douglas

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense...

Long non-coding RNA and extracellular matrix: the hidden players in cancer-stroma cross-talk

December 2018
Edoardo D'Angelo | Marco Agostini

Currently available high-throughput technologies combined with bioinformatics analyses revealed that nearly 80% of the genome is transcribed, whereas only 2% of the genetic code is translated in proteins....

Relations between approved platinum drugs and non-coding RNAs in mesothelioma

December 2018
Bernhard Biersack

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically...

Macro roles for microRNAs in neurodegenerative diseases

September 2018
Dipen Rajgor

Neurodegenerative diseases (NDs) are typically adult-onset progressive disorders that perturb neuronal function, plasticity and health that arise through a host of one or more genetic and/or environmental...

Myocardial cell-to-cell communication via microRNAs

September 2018
Lara Ottaviani | Marida Sansonetti | Paula A. da Costa Martins

The ensemble diversity of non-coding RNA structure is lower than random sequence

September 2018
Walter N. Moss

In addition to energetically optimal structures, RNAs can fold into near energy suboptimal conformations that may be populated and play functional roles. The diversity of this structural ensemble can...

BC200 (BCYRN1) – The shortest, long, non-coding RNA associated with cancer

September 2018
J. Samson | S. Cronin | K. Dean

With the discovery that the level of RNA synthesis in human cells far exceeds what is required to express protein-coding genes, there has been a concerted scientific effort to identify, catalogue and...

Long non-coding RNAs in the failing heart and vasculature

September 2018
Steffie Hermans-Beijnsberger | Marc van Bilsen | Blanche Schroen

Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function...

Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies: Hype or hope?

June 2018
Hetty Helsmoortel | Celine Everaert | Nicolaas Lumen | Piet Ost | Jo Vandesompele

Prostate cancer is a heterogeneous malignancy, with clinical courses widely differing between indolent and aggressive lethal disease. This heterogeneity calls for a more personalized approach towards...

Molecular functions and specific roles of circRNAs in the cardiovascular system

June 2018
Lesca M. Holdt | Alexander Kohlmaier | Daniel Teupser

As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge...

Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis

June 2018
Jameel M. Abduljalil

Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or...

Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs

June 2018
Vasiliki Zarkou | Alexandros Galaras | Antonis Giakountis | Pantelis Hatzis

The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway...

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

March 2018
John Aird | Anne-Marie Baird | Marvin C.J. Lim | Ray McDermott | Stephen P. Finn | Steven G. Gray

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion...

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