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Recent Non-coding RNA Research Articles

Recently published articles from Non-coding RNA Research.

Non-coding RNA regulation in reproduction: Their potential use as biomarkers

June 2019
Vanesa Robles | David G. Valcarce | Marta F. Riesco

Non-coding RNAs (ncRNAs) are crucial regulatory elements in most biological processes and reproduction is also controlled by them. The different types of ncRNAs, as well as the high complexity of these...

The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs

June 2019
Oxana V. Klimenko | Alexey Sidorov

Virus-induced cellular genetic modifications result in the development of many human cancers....

Dietary non-coding RNAs from plants: Fairy tale or treasure?

June 2019
Gopinath M. Sundaram

The past two decades have witnessed soaring interest in the field of non-coding RNAs, largely attributed by its regulatory role in controlling two third of human transcriptional output. Though, there...

Long non-coding RNAs in cancer

June 2019
Mi-Young Kim

C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks

June 2019
Stefan Stamm | J. Stephen Lodmell

C/D box snoRNAs (SNORDs) are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate...

On a stake-out: Mycobacterial small RNA identification and regulation

Available online 16 May 2019
Sagarika Taneja | Tanmay Dutta

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their survival in the...

Thank you note

March 2019

Long non-coding RNAs: Functional regulatory players in breast cancer

March 2019
Rana Ahmed Youness | Mohamed Zakaria Gad

Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional...

miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

March 2019
Valérie Metzinger-Le Meuth | Laurent Metzinger

microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded...

Circular RNA expression and function in the brain

March 2019
Shobana Sekar | Winnie S. Liang

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for...

Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics

March 2019
Elisa De Paola | Veronica Verdile | Maria Paola Paronetto

In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases....

Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development

December 2018
Vanessa Zammit | Mark R. Brincat | Viktor Cassar | Yves Muscat-Baron | Duncan Ayers | Byron Baron

Mesenchymal Stem Cells (MSCs) are widely used in therapeutic applications. Their plasticity and predisposition to differentiate into a variety of cell types, including those of the neuronal lineage,...

NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

Long non coding RNAs and ALS: Still much to do

December 2018
Stella Gagliardi | Cecilia Pandini | Maria Garofalo | Matteo Bordoni | Orietta Pansarasa | Cristina Cereda

Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated...

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma

December 2018
Bernhard Biersack

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The...

LONG-NONCODING RNAs in gastroesophageal cancers

December 2018
Giuseppe Nicolò Fanelli | Pierluigi Gasparini | Irene Coati | Ri Cui | Hubert Pakula | Basudev Chowdhury | Nicola Valeri | Fotios Loupakis | Juozas Kupcinskas | Rocco Cappellesso | Matteo Fassan

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates....

Non-coding RNA influences in dementia

December 2018
Duncan Ayers | Charles Scerri

Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other...

Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

December 2018
Andrew G.L. Douglas

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense...

Long non-coding RNA and extracellular matrix: the hidden players in cancer-stroma cross-talk

December 2018
Edoardo D'Angelo | Marco Agostini

Currently available high-throughput technologies combined with bioinformatics analyses revealed that nearly 80% of the genome is transcribed, whereas only 2% of the genetic code is translated in proteins....

Relations between approved platinum drugs and non-coding RNAs in mesothelioma

December 2018
Bernhard Biersack

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically...

Macro roles for microRNAs in neurodegenerative diseases

September 2018
Dipen Rajgor

Neurodegenerative diseases (NDs) are typically adult-onset progressive disorders that perturb neuronal function, plasticity and health that arise through a host of one or more genetic and/or environmental...

Myocardial cell-to-cell communication via microRNAs

September 2018
Lara Ottaviani | Marida Sansonetti | Paula A. da Costa Martins

The ensemble diversity of non-coding RNA structure is lower than random sequence

September 2018
Walter N. Moss

In addition to energetically optimal structures, RNAs can fold into near energy suboptimal conformations that may be populated and play functional roles. The diversity of this structural ensemble can...

BC200 (BCYRN1) – The shortest, long, non-coding RNA associated with cancer

September 2018
J. Samson | S. Cronin | K. Dean

With the discovery that the level of RNA synthesis in human cells far exceeds what is required to express protein-coding genes, there has been a concerted scientific effort to identify, catalogue and...

Long non-coding RNAs in the failing heart and vasculature

September 2018
Steffie Hermans-Beijnsberger | Marc van Bilsen | Blanche Schroen

Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function...

Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies: Hype or hope?

June 2018
Hetty Helsmoortel | Celine Everaert | Nicolaas Lumen | Piet Ost | Jo Vandesompele

Prostate cancer is a heterogeneous malignancy, with clinical courses widely differing between indolent and aggressive lethal disease. This heterogeneity calls for a more personalized approach towards...

Molecular functions and specific roles of circRNAs in the cardiovascular system

June 2018
Lesca M. Holdt | Alexander Kohlmaier | Daniel Teupser

As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge...

Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis

June 2018
Jameel M. Abduljalil

Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or...

Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs

June 2018
Vasiliki Zarkou | Alexandros Galaras | Antonis Giakountis | Pantelis Hatzis

The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway...

Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart

March 2018
F. De Majo | M. Calore

Epigenetics refers to all the changes in phenotype and gene expression which are not due to alterations in the DNA sequence. These mechanisms have a pivotal role not only in the development but also...

Circular RNAs in the cardiovascular system

March 2018
Clarissa P.C. Gomes | Antonio Salgado-Somoza | Esther E. Creemers | Christoph Dieterich | Mitja Lustrek | Yvan Devaux

Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding...

The noncoding-RNA landscape in cardiovascular health and disease

March 2018
Vittoria Di Mauro | Maria Barandalla-Sobrados | Daniele Catalucci

The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in the human body. Therefore any alteration in regulatory networks that orchestrate heart development as well...

Carcinogenesis in prostate cancer: The role of long non-coding RNAs

March 2018
John Aird | Anne-Marie Baird | Marvin C.J. Lim | Ray McDermott | Stephen P. Finn | Steven G. Gray

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion...

Translational applications of microRNAs in cancer, and therapeutic implications

September 2017
Grace T. Kwok | Jing Ting Zhao | Jocelyn Weiss | Nancy Mugridge | Himanshu Brahmbhatt | Jennifer A. MacDiarmid | Bruce G. Robinson | Stan B. Sidhu

The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these...

LncRNA secondary structure in the cardiovascular system

September 2017
Leonie Martens | Frank Rühle | Monika Stoll

Long non-coding RNAs (lncRNAs) have been increasingly studied during the past decade. This led to an immense number of annotated transcripts, out of which many were linked to a diverse range of biological...

Long noncoding RNAs in the initiation, progression, and metastasis of hepatocellular carcinoma

September 2017
Johanna K. DiStefano

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Despite awareness of risk factors for the development of HCC and advances in the diagnosis and clinical management...

Clinical significance of CRNDE transcript variants in glioblastoma multiforme

June 2017
Karrie M.Y. Kiang | Gilberto K.K. Leung

The long non-coding RNA CRNDE is an oncogene that promotes tumor growth in glioblastoma multiforme (GBM). At least five CRNDE transcript variants with possibly different functional roles have been described...

Unraveling long non-coding RNAs through analysis of high-throughput RNA-sequencing data

June 2017
Rashmi Tripathi | Pavan Chakraborty | Pritish Kumar Varadwaj

Extensive genome-wide transcriptome study mediated by high throughput sequencing technique has revolutionized the study of genetics and epigenetic at unprecedented resolution. The research has revealed...

Non-coding RNAs are promising targets for stem cell-based cancer therapy

June 2017
Naoya Sakamoto | Ririno Honma | Yohei Sekino | Keisuke Goto | Kazuhiro Sentani | Akira Ishikawa | Naohide Oue | Wataru Yasui

The term “non-coding RNA” (ncRNA) is generally used to indicate RNA that does not encode a protein and includes several classes of RNAs, such as microRNA and long non-coding RNA. Several lines of evidence...

Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing

June 2017
Elena Garreta | Patricia Prado | Juan Carlos Izpisua Belmonte | Nuria Montserrat

In recent years, different studies have revealed that adult mammalian cardiomyocytes have the capacity to self-renew under homeostatic conditions and after myocardial injury. Interestingly, data from...

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