Hemorrhage in brain tumor – An unresolved issue
June 2022
Intratumoral hemorrhage (ITH) as a variant of intracranial hemorrhage (ICH) is a known, albeit rare, clinical entity. Hemorrhages within brain neoplasms seem to remain underreported, including angiomatous...
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Clinical treatment progress of small amounts thalamus hemorrhage
June 2021
Thalamic hemorrhage is one of deep-seating cerebral lesions. Conservative therapy is preferred to patients with minor thalamic hemorrhage, and external ventricular drainage is usually applied in patients...
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Reliability of Siriraj stroke score to distinguish between hemorrhagic and ischemic stroke
March 2023
The aim of study was to establish a quick way to differentiate between hemorrhagic and ischemic stroke by using siriraj stroke score and find its specificity and sensitivity by comparing it with CT...
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Anticoagulant-associated intracerebral hemorrhage
March 2020
Intracerebral hemorrhage (ICH) is the most dangerous complication of oral anticoagulant treatment (OAT). Up to half of patients with OAT-related ICH experience early clinical deterioration due to active...
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Cerebral vasospasm after subarachnoid hemorrhage: Developing treatments
March 2021
Subarachnoid hemorrhage (SAH) can be devastating with high morbidity and mortality. A common sequela is cerebral vasospasm, the narrowing of cerebral blood vessels that can lead to ischemic stroke if...
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Behavioral tests in rodent models of stroke
December 2020
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties...
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The effect of cocaine and methamphetamine on saccular aneurysm formation and rupture: A literature review
September 2021
The pathophysiology of saccular aneurysm rupture (berry aneurysm) secondary to cocaine and methamphetamine use has been classically attributed to their effects on cerebrovasculature. We conducted a...
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Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report
February 2024
Falx interhemispheric subdural hematoma (FISH) is a rare subtype of subdural hematoma that occurs between the cerebral hemispheres along with falx cerebri. It represents less than 0.5% of all subdural...
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Inflammatory response in sepsis and hemorrhagic stroke
June 2023
Exaggerated/deregulated inflammatory response is a major medical problem that is often associated with bad outcomes or even the death of the patient. Sepsis and severe hemorrhagic stroke are two illustrative...
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The blood brain barrier in cerebral ischemic injury – Disruption and repair
March 2020
With the emergence of novel technologies and ground breaking concepts in BBB basic research in the past decades, the researchers’ attention on the critical role of blood brain barrier (BBB) integrity...
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Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?
April 2024
An aneurysmal subarachnoid hemorrhage (aSAH) is a devastating event associated with a high mortality and morbidity rate. Though numerous medications are used to prevent cerebral vasospasm and vasospasm-related...
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Managing Mental Disorders in Intracranial Hemorrhage (ICH) Patients: A Case Study on The Importance of Early Recognition and Intervention
February 2024
Intracranial Hemorrhage (ICH) can lead to various clinical manifestations and complications. These include mental disorders that range from impaired cognitive function to disturbances in the sensorium,...
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Collaterals in ischemic stroke
March 2020
Collateral flow plays a pivotal role, both in acute and chronic phases of cerebral ischemia. Recruitment of these redundant vascular networks maintains cerebral blood flow to ischemic areas, while primary...
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A translational perspective on intracranial pressure responses following intracerebral hemorrhage in animal models
March 2021
As with ischemic and traumatic brain injury, raised intracranial pressure (ICP) is a common life-threatening complication of intracerebral hemorrhage (ICH). Elevated ICP can lead to cerebral ischemia,...
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Crescent-shaped enhancement in cranial CT angiography: A manifestation of intracerebral hematoma expansion
June 2022
Hematoma expansion is a known predictor of poor clinical outcome in patients who suffered a spontaneous intracerebral hemorrhage (ICH). A spot sign seen on computed tomography (CT) angiography (CTA)...
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Comparison of accuracy, sensitivity and specifity of Bahrudin score vs Siriraj score vs Gajah Mada algorithm in diagnosing type of stroke
December 2022
Rapid diagnosis is crucial for stroke patients since it is an emergency that may result in morbidity and mortality. The gold standard, which is a CT scan of the brain is not always feasible, hence,...
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Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
December 2022
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease with vascular amyloid-β deposits and is commonly observed among the elderly. Often associated with Alzheimer’s disease, CAA is among the...
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Neurological complications and effects of COVID-19: Symptoms and conceivable mechanisms
September 2023
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December 2019 in Wuhan, China. The new coronavirus disease (COVID-19) was declared a global...
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Initial results of clazosentan with multiple-drug management for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
April 2024
Cerebral vasospasm is an unelucidated complication of subarachnoid hemorrhage. Various treatments exist against cerebral vasospasms however, consensus on the optimal treatment is lacking. We use clazosentan,...
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Emerging regenerative medicine for hemorrhagic stroke: An update on stem cell therapies
March 2023
Hemorrhagic stroke (HS) is a disastrous occurrence with high mortality rates, however, there are no established treatments for this pathology. Given recent advances in stem cell therapies, concerted...
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Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage
April 2024
This retrospective study aimed to analyze the prospectively collected data of computed tomography (CT) perfusion imaging and to examine if clazosentan add-on administration prevented post-subarachnoid...
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Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm
April 2024
Clazosentan (CLA) reduces cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). However, adverse events including pulmonary edema were reported. We examined whether the strict management...
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Middle meningeal artery embolization may be an effective treatment for patients with chronic subdural hematoma resistant to atorvastatin
December 2023
To investigate the efficacy and safety of MMA embolization in patients with CSDH who failed atorvastatin treatment....
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Progress in the treatment of chronic intracranial large artery occlusion: Time for large, randomized trials?
December 2023
Chronic cerebral artery occlusion is an important cause of ischemic stroke, resulting in up to 45% of all ischemic strokes. Therefore, treatment of chronic cerebral artery occlusion is critical to improve...
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Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: A case series
April 2024
Pulmonary edema is a common complication in patients receiving clazonsentan. Here, we report our experience in managing fluid balance with loop diuretics in patients with aneurysmal subarachnoid hemorrhage...
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