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Recent Brain Hemorrhages Articles

Recently published articles from Brain Hemorrhages.

SARS-CoV-2 infection with pneumonia and stroke

Available online 2 February 2021
Muhammad Hassan | Fibhaa Syed | Fatima Mustafa | Hafiza Faiza Mushtaq | Naveed Ullah Khan | Mazhar Badshah

Covid-19 pandemic has been manifested mainly as respiratory and constitutional symptoms. Though, it may demonstrate the involvement of other systems i.e. cardiovascular system (CVS), central nervous...

MMP-2/9-cleaved occludin promotes endothelia cell death in ischemic stroke

Available online 2 February 2021
Rong Pan | Wenlan Liu | Ke Jian Liu

Although recanalization via thrombolysis and/or thrombectomy has proven to be a beneficial treatment for ischemic stroke, their application are severely limited due to increased risk of symptomatic...

Proteomic analysis of rat brain related to mass effect after experimental intracerebral hemorrhage

Available online 2 February 2021
Yumei Wang | Zongkun Hou | Yuhua Gong | Shilei Hao | Bochu Wang

Precision of minimally invasive surgery for intracerebral hemorrhage treatment

December 2020
Ge Zhang | Chao Pan | Ping Zhang | Devin W. McBride | Yingxin Tang | Guofeng Wu | Zhouping Tang

Minimally invasive surgery has been widely used in the treatment of patients with intracerebral hemorrhage in recent years, and has achieved good clinical efficacy. Based on the basic theory of minimally...

Behavioral tests in rodent models of stroke

December 2020
Jingsong Ruan | Yao Yao

Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties...

Time-dependent progression of hemorrhagic transformation after transient ischemia and its association with GPR68-dependent protection

December 2020
Tao Wang | Mindi He | Xiang-ming Zha

Hemorrhagic transformation (HT) following ischemia is one complication which worsens stroke outcome. During and after ischemia–reperfusion, persistent reduction of brain pH occurs. In a recent study,...

A case of reversible cerebral vasoconstriction syndrome with intracranial hemorrhage

December 2020
Satoshi Fujita | Morito Hayashi | Sho Sato | Yu Hiramoto | Haruo Nakayama | Keisuke Ito | Norihiko Saito | Satoshi Iwabuchi

A 54-year-old woman complained about a headache. Six days later, she developed subcortical hemorrhage (4 × 4 × 5 cm) due to reversible cerebral vasoconstriction syndrome (RCVS). She underwent a craniotomy...

SPARKLE trial kick-off meeting was successfully held

December 2020
Jie Jing | Jingfei Yang

Advancement in the haemodynamic study of intracranial aneurysms by computational fluid dynamics

Available online 18 December 2020
Tao Wu | Qing Zhu

As a promising risk stratification tool, computational fluid dynamics plays an important role in the evaluation of the growth and rupture of intracranial aneurysms. However, many of the experimental...

Clinical treatment progress of small amounts thalamus hemorrhage

Available online 18 December 2020
Yongtao Lv | Wei Wei

Thalamic hemorrhage is one of deep-seating cerebral lesions. Conservative therapy is preferred to patients with minor thalamic hemorrhage, and external ventricular drainage is usually applied in patients...

Diabetes mellitus: A common comorbidity increasing hemorrhagic transformation after tPA thrombolytic therapy for ischemic stroke

Available online 28 November 2020
Yinghua Jiang | Jinrui Han | Pierce Spencer | Yadan Li | Samuel J. Vodovoz | Ming-Ming Ning | Ning Liu | Xiaoying Wang | Aaron S. Dumont

Intravenous tissue type plasminogen activator thrombolytic therapy has long been a mainstay in acute ischemic stroke therapy. However, patients receiving IV tPA therapy may have variable response with...

The effect of cocaine and methamphetamine on saccular aneurysm formation and rupture: A literature review

Available online 28 November 2020
Yazeed W. Haddad | Ejona Korcari | Gina Natasha Polsinelli | Ding Yuchuan

The pathophysiology of saccular aneurysm rupture (berry aneurysm) secondary to cocaine and methamphetamine use has been classically attributed to their effects on cerebrovasculature. We conducted a...

COVID-19 and stroke: A review

Available online 17 November 2020
Xiaoming Qi | Kristin A. Keith | Jason H. Huang

COVID-19 patients have presented with a wide range of neurological disorders, among which stroke is the most devastating. We have reviewed current studies, case series, and case reports with a focus...

The role of mural cells in hemorrhage of brain arteriovenous malformation

Available online 3 November 2020
Peipei Pan | Sonali S Shaligram | Leandro Barbosa Do Prado | Liangliang He | Hua Su

Brain arteriovenous malformation (bAVM) is the most common cause of intracranial hemorrhage (ICH), particularly in young patients. However, the exact cause of bAVM bleeding and rupture is not yet fully...

Therapeutic effects of exosomes from angiotensin-converting enzyme 2 -overexpressed endothelial progenitor cells on intracerebral hemorrhagic stroke

Available online 3 November 2020
Jinju Wang | Shuzhen Chen | Sri Meghana Yerrapragada | Wenfeng Zhang | Ji C. Bihl

We have previously demonstrated that angiotensin-converting enzyme 2 (ACE2) could boost the therapeutic effects of endothelial progenitor cells (ACE2-EPCs) on stroke. However, where this effect comes...

A translational perspective on intracranial pressure responses following intracerebral hemorrhage in animal models

Available online 29 October 2020
Cassandra M. Wilkinson | Tiffany F.C. Kung | Glen C. Jickling | Frederick Colbourne

As with ischemic and traumatic brain injury, raised intracranial pressure (ICP) is a common life-threatening complication of intracerebral hemorrhage (ICH). Elevated ICP can lead to cerebral ischemia,...

Poor grade subarachnoid hemorrhage: Treatment decisions and timing influence outcome. Should we, and when should we treat these patients?

Available online 21 October 2020
N. Brawanski | D. Dubinski | M. Bruder | J. Berkefeld | E. Hattingen | C. Senft | V. Seifert | J. Konczalla

A poor admission status (World Federation of Neurosurgical Science (WFNS) IV-V) after aneurysmal subarachnoid hemorrhage (SAH) is well known as a negative prognostic factor for the future outcome of...

Rebleeding after minimally invasive surgery for intracerebral hemorrhage: A mini-review

Available online 21 October 2020
Wenliang Guo | Guangyu Guo | Shuang Bai | Hong Deng | Yuping Tang | Qingwu Yang | Qiang Dong | Wenzhi Wang | Chao Pan | Zhouping Tang

Intracerebral hemorrhage (ICH) is the most disabling form of stroke, but effective treatment protocols for ICH are still limited. The minimally invasive surgery (MIS) is a potential and effective treatment...

Classification mechanism and clinical analysis of perihematomal edema in intracerebral hemorrhage

September 2020
Shuhua Xie | Zhengfang Qin | Xiaoping Yin

The classification and mechanism of perihematomal edema in cerebral hemorrhage are complicated. The edema theory in different periods needs to be unified due to various reasons. Secondary perihematomal...

Fractalkine/CX3CR1 pathway is neuroprotective in intracerebral hemorrhage through facilitating the expression of TGF-β1

September 2020
Hai-Han Yu | Gai-Gai Li | Ying-Xin Tang | Shuang Bai | Chao Pan | Zhou-Ping Tang

Pronounced inflammation after intracerebral hemorrhage (ICH) contributes to secondary brain injury, which seriously affects the prognosis of ICH patients. Fractalkine (FKN)/CX3CR1 pathway may play an...

Absolute hypodensity sign by noncontrast computed tomography as a reliable predictor for early hematoma expansion

September 2020
Heling Chu | Chuyi Huang | Jing Dong | Qiang Dong | Yuping Tang

Early hematoma expansion in intracerebral hemorrhage (ICH) patients is strongly associated with poor outcome and potentially preventable if high-risk patients are timely identified. We aimed to investigate...

Cerebral Salt-Wasting Syndrome and Elevated Brain Natriuretic Peptide Levels caused by Minor Traumatic Brain Injury: A case report

September 2020
Dinh Thi Phuong Hoai | Bui Long The | Tran Thi Mai Dieu | Le Nha Duyen | Mai Dang Thi | Nguyen Thanh Minh

Hyponatremia can be caused by various conditions such as Cerebral Salt Wasting Syndrome (CSWS), Inadequate Antidiuretic Hormone Secretion (SIADH), secondary adrenal dysfunction and thyroid dysfunction....

Therapeutic time window of minimally invasive surgery for intracerebral hemorrhage

September 2020
Guangyu Guo | Wenliang Guo | Yangyang Feng | Hong Deng | Ping Zhang | Yingxin Tang | Guofeng Wu | Qi Li | Chao Pan | Zhouping Tang

Since mass effect and secondary brain injuries persist in the pathogenesis of intracerebral hemorrhage, hematoma evacuation within a limited time is reasonable. However, it is complex to define an accurate...

Phenotype change of polarized microglia after intracerebral hemorrhage: Advances in research

September 2020
Ran Tang | Zhuyi Huang | Heling Chu

Spontaneous intracerebral hemorrhage (ICH) accounts for approximately 10–15% of all strokes with high rates of mortality and residual disability. Multiple studies have demonstrated that microglia-mediated...

Cerebral vasospasm after subarachnoid hemorrhage: Developing treatments

Available online 1 September 2020
Alvin Y. Chan | Elliot H. Choi | Ichiro Yuki | Shuichi Suzuki | Kiarash Golshani | Jefferson W. Chen | Frank P.K. Hsu

Subarachnoid hemorrhage (SAH) can be devastating with high morbidity and mortality. A common sequela is cerebral vasospasm, the narrowing of cerebral blood vessels that can lead to ischemic stroke if...

Spreading depolarization evoked by endothelin-1 is inhibited by octanol but not by carbenoxolone

Available online 1 September 2020
Gabor C. Petzold | Jens P. Dreier

Spreading depolarization (SD) has been implicated in the pathogenesis of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. Endothelin-1 (ET-1) is a powerful trigger of SD and may be involved...

Scanning electron microscopy analysis of incidence and growth pattern of experimentally induced intracranial aneurysms in rat model

Available online 22 July 2020
Lucia Schwyzer | Serge Marbacher | Javier Fandino | Aaron S. Dumont

Experimental animal models are most valuable to study the initiation and growth of cerebral aneurysms. The aim of our study is to analyze the time course, incidence, location and growth pattern of intracranial...

Behavioral assessment of post-stroke depression and anxiety in rodents

June 2020
Danyang Chen | Junmin Wang | Yinpei Xing | Peijun Jia | Yuheng Zhang | Jiarui Wang | Honglei Ren | Anh Le | Xuemei Chen | Jian Wang

In this review, we compare behavioral protocols (e.g., equipment specification, test duration), evaluation indexes, application characteristics, and advantages and disadvantages of six tests used to...

Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke

June 2020
Yu Hasegawa | Cao Cheng | Kenyu Hayashi | Yushin Takemoto | Shokei Kim-Mitsuyama

Stroke is a primary cause of death and a leading cause of disability throughout the world. Although researchers have long studied ways for improving mortality and morbidity, few effective treatments...

The effectiveness of hyperbaric oxygen modalities against vascular component of traumatic brain injury

June 2020
Robert P. Ostrowski | Emanuela Pucko | Ewa Matyja

Intracranial bleeding occurs in a substantial percentage of patients with neurotrauma and may gravely impact clinical outcomes. Hyperbaric oxygen (HBO) has been tested for traumatic brain injury (TBI),...

Up-regulation of PPARγ, Nrf2 and HO-1 in microglia activated by thrombin

June 2020
Hang Hang | Likun Wang | Guofeng Wu | Siying Ren

To explore the molecular mechanism involved in secondary brain damage caused by intracerebral hemorrhage (ICH), we activated microglia by thrombin, to observe the changes of peroxisome proliferator-activated...

Imaging predictors for hematoma expansion in patients with intracerebral hemorrhage: A current review

June 2020
Xin-Ni Lv | Qi Li

Spontaneous intracerebral hemorrhage (ICH) is the common subtype of stroke and has a higher risk of morbidity and mortality than ischemic stroke. Early enlargement of the hematoma has been identified...

Mechanisms and potential therapeutic targets for spontaneous intracerebral hemorrhage

June 2020
Wei Hua | Xuemei Chen | Junmin Wang | Weidong Zang | Chao Jiang | Honglei Ren | Michael Hong | Jiarui Wang | He Wu | Jian Wang

In this review paper, the most recent research on intracerebral hemorrhage (ICH) is summarized and novelperspectives are offered on the pathomechanisms of ICH. These underlying pathomechanisms of ICH...

Intracerebral hemorrhage in translational research

March 2020
Ruiyi Zhang | Qian Bai | Yang Liu | Yan Zhang | Zhaofu Sheng | Mengzhou Xue | V. Wee Yong

Intracerebral hemorrhage (ICH) is a serious stroke subtype with high morbidity and mortality. The prognosis of ICH is poor. In recent years, there have been many studies on how to improve the prognosis...

Double porous media modeling in computational fluid dynamics for hemodynamics of stent-assisted coiling of intracranial aneurysms: A technical case report

March 2020
Masanori Tsuji | Fujimaro Ishida | Tomoyuki Kishimoto | Kazuhiro Furukawa | Yoichi Miura | Masato Shiba | Takanori Sano | Keiji Fukazawa | Katsuhiro Tanaka | Hiroshi Tanemura | Yasuyuki Umeda | Ryuta Yasuda | Shinichi Shimosaka | Hidenori Suzuki

Endovascular therapy is developing, but not all aneurysms are completely obliterated even by using the techniques such as stent-assisted coiling or a flow diverter. To predict the aneurysm-occlusion...

Predictors of risk of intracerebral hemorrhage after intracranial artery intervention in intracranial atherosclerotic stenosis patients

March 2020
Liang Liu | Jie Li | Qing-Wu Yang

To investigate the relationship between clinical characters of intracranial atherosclerotic stenosis patients and occurrence of cerebral hemorrhage after intracranial artery intervention. Clinical data...

Temporal evolution of heme oxygenase-1 expression in reactive astrocytes and microglia in response to traumatic brain injury

March 2020
Alexander Morita | Amandine Jullienne | Arjang Salehi | Mary Hamer | Emon Javadi | Yasir Alsarraj | Jiping Tang | John H. Zhang | William J. Pearce | André Obenaus

Heme oxygenase-1 (HO-1) is an inducible enzyme that catabolizes heme into biliverdin (which is converted to bilirubin), carbon monoxide, and free iron. HO-1 and its downstream molecules have antioxidant...

Comparison of transradial and transfemoral cerebral angiography

March 2020
M.D. Liu | Gai Y.T.

To compare the feasibility, safety and effectiveness of transradial and transfemoral artery puncture cerebral angiography....

Artificial intelligence: The dawn of a new era for cutting-edge technology based diagnosis and treatment for stroke

March 2020
Yang Ma | Ping Zhang | Yingxin Tang | Chao Pan | Gaigai Li | Na Liu | Yang Hu | Zhouping Tang

Stroke is the second leading cause of death worldwide. Therefore, research on prevention and treatment for stroke has great significance. In recent years, the development of artificial intelligence...

Effects of the treatment timing of minimally invasive surgery and urokinase dosage on perihaematomal oedema in intracerebral hemorrhage evacuation

March 2020
Yang Ma | Ping Zhang | Yingxin Tang | Xiaohua Yang | Zhouping Tang

The main aims of the study were to explore the correlation between different times of a minimally invasive operation and perihaematomal oedema properties in patients with cerebral hemorrhage, to identify...

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

March 2020
Zhe Kang Law | Michael Desborough | Kamini Rakkar | Philip M. Bath | Ulvi Bayraktutan | Nikola Sprigg

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH...

Anticoagulant-associated intracerebral hemorrhage

March 2020
Andrea Morotti | Joshua N. Goldstein

Intracerebral hemorrhage (ICH) is the most dangerous complication of oral anticoagulant treatment (OAT). Up to half of patients with OAT-related ICH experience early clinical deterioration due to active...

Effects of apple polyphenols on oxidative stress and cerebral vasospasm after subarachnoid hemorrhage in a rabbit double hemorrhage model

March 2020
Masato Naraoka | Yuchen Li | Takeshi Katagai | Hiroki Ohkuma

Subarachnoid hemorrhage (SAH) is almost always caused by ruptured cerebral aneurysms, and the most serious complication after SAH is cerebral vasospasm. Oxidative stress due to free radicals released...

The blood brain barrier in cerebral ischemic injury – Disruption and repair

March 2020
Wenting Zhang | Ling Zhu | Chengrui An | Rongrong Wang | Liqun Yang | Weifeng Yu | Peiying Li | Yanqin Gao

With the emergence of novel technologies and ground breaking concepts in BBB basic research in the past decades, the researchers’ attention on the critical role of blood brain barrier (BBB) integrity...

Collaterals in ischemic stroke

March 2020
Konark Malhotra | David S. Liebeskind

Collateral flow plays a pivotal role, both in acute and chronic phases of cerebral ischemia. Recruitment of these redundant vascular networks maintains cerebral blood flow to ischemic areas, while primary...

Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke

March 2020
Sydney Corey | Brooke Bonsack | Matt Heyck | Alex Shear | Nadia Sadanandan | Henry Zhang | Cesar V. Borlongan

Hemorrhagic stroke is a global health crisis plagued by neuroinflammation in the acute and chronic phases. Neuroinflammation approximates secondary cell death, which in turn robustly contributes to...

Imaging markers in acute phase of stroke: Implications for prognosis

March 2020
Ying Zhou | Sheng Zhang | Min Lou

Currently, various methods for inspecting ischemic stroke are available, especially the imaging techniques, which play an important role in assisting diagnosis and prognostication of ischemic stroke....

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