Comparison of two hemostatic skin adhesive dressings, incorporating multi-metal bioactive glass
2025
•Multi-element bioactive glass nanoparticles (BG) were successfully synthesized.•Two skin adhesives, with GelMA back bone, based on adhesive molecules of DOPA and TA, integrating BG were developed.•Both...
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Targeted drug delivery system for Golgi apparatus's diseases
2025
•Snapshot of Golgi apparatus.•Design scheme for targeting Golgi apparatus.•Typical application of Golgi targeting in disease surveillance and therapy....
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ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration
2025
•ORM1 was expressed in AIS bone tissues.•ORM1-positive AIS patient-derived osteoblasts, there was an increased expression of RANKL, decreased expression of OPG.•Osteoclasts overexpressing ORM1 promoted...
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Bioactive scaffolds integrated with micro-precise spatiotemporal delivery and in vivo degradation tracking for complex tissue regeneration
2025
•This study we report groundbreaking preclinical outcomes in the functional regeneration of temporomandibular joint (TMJ) discs of mini-pigs using anatomically correct bioactive 3D-printed scaffolds.•The...
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Integrating bioprinted oral epithelium with millifluidics for fluorouracil perfusion and Fusobacterium infection to bioengineer oral mucositis-on-a-chip
2025
•Magnetic 3D bioassembly or bioprinting can promptly produce physiologically relevant multi-layered oral epithelial sheets from human oral keratinocytes.•Our dynamic millifluidic system can generate...
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Ultrasonic manipulation in tissue engineering
2025
•This review systematically explores the application of ultrasonic waves in tissue engineering, emphasizing their safe, contactless, and precise capabilities for cell manipulation and tissue morphogenesis.•It...
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Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applications
2025
•3D hybrid scaffolds improve biocompatibility and biomechanical properties.•Nano-topography enhances cellular interactions and scaffold performance.•4D printing enables dynamic, stimuli-responsive tissue...
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Transcript-activated collagen matrix for enhanced bone marrow stem cell differentiation and osteochondral repair
2025
•Transcript-activated collagen matrix delivers TGF-β3 mRNA for enhanced osteochondral repair.•Localized and sustained delivery of TGF-β3 promotes BMSC differentiation into chondrocytes.•Chemically modified...
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Novel microsphere scaffold-based islet organoids for rescuing type 1 diabetes and reversing hyperglycemia
2025
•Three-dimensional porous microsphere scaffolds are constructed based on microfluidic technology to form a multi-stage pore network through controlled stacking to promote cell infiltration and material...
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Force induces axon growth in inhibitory conditions
2025
•Nano-pulling is a technology that utilizes magnetic nanoparticles and magnetic fields to mechanically stimulate neurons.•Nano-pulling induces axon growth in hippocampal neurons in the presence of repulsive...
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Engineering Neuroblastoma Models for Clinical Translation*
Available online 6 June 2025
•Children diagnosed with high-risk neuroblastoma exhibit limited significant therapeutic benefits from the administration of chemotherapy and immunotherapy.•The heterogeneity observed in neuroblastoma...
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MicroRNAs and mRNAs: A Comparative Analysis in Translation and Commercialization
Available online 16 April 2025
•Examines the potential of microRNAs as next-generation therapeutics•Compares microRNAs and mRNAs in translation and commercialization prospects•Highlights microRNAs’ unique gene-regulatory roles in...
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Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing
December 2024
•A sprayable, efficient and convenient TACo nanozyme was designed via one-pot method.•TACo nanozyme exhibit pH-responsive and photothermal antibacterial properties.•TACo nanozyme can effectively relieve...
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Bone improvement in osteoporotic rabbits using CoCrMo implants
December 2024
•Metallic biomaterial helps to improve osteoporotic cortical bone.•The experience performed in animals reflected an increase in bone quality.•After 8 weeks, there was marked osteogenesis with both apposition...
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Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
December 2024
•Highly bioactive ECM microfibers serve as reinforce phase to strengthen CSH/CP@ECM-Deno mechanical property similar to cancellous bone.•Long-term release of denosumab regulates osteoclastogenesis by...
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Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
December 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
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Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
December 2024
•We have developed Bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase with high availability and bioactivity.•Our verification, using...
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A patch comprising human umbilical cord-derived hydrogel and mesenchymal stem cells promotes pressure ulcer wound healing
December 2024
•Patch of MSCs/dECM accelerated wound healing and enhanced re-epithelialization of PU in mice.•This effect can be attributed to the promotion of tissue re-epithelialization, collagen deposition, angiogenesis,...
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Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
December 2024
•Cochlear implant/MXene-based electricacoustic stimulation system is proposed and constructed.•Low-frequency electroacoustic stimulation promotes the growth and development of SGNs.•Low-frequency electroacoustic...
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Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip
September 2024
•The liver organoids-on-a-chip platform could recapitulate key features of human liver physiology.•Free fatty acid-induced liver organoids displayed typical pathological characteristics similar to those...
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Intelligent hydrogels for treating malignant melanoma
September 2024
•Potential options for treatment of malignant melanoma (MM) are being presented by emerging therapies like immunotherapy, photodynamic therapy and photothermal therapy due to their effective and secure...
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Advances in nano silver-based biomaterials and their biomedical applications
September 2024
•We report the various physical, chemical and biological methods for AgNP synthesis.•Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry.•Unique optical properties of AgNPs...
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Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
September 2024
•Green synthesized silver nanoparticles have shown promising results in wound healing, promoting faster healing and reducing infection risk.•These environmentally friendly nanoparticles offer a sustainable...
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Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression
September 2024
•3-Dimensional matrix fabricated from poly-l-lactide acid (PLLA) with collagen coating (PLLA/CC) displayed great biocompatibility and biodegradability properties.•Immobilization of conditioned medium...
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Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
September 2024
•The mechanism of osteoclastogenesis induced by rankl is very important.•Oleandin can inhibit RANKL-induced osteoclast formation and bone resorption in vitro.•Oleandrin effectively inhibited lipopolysaccharide-induced...
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