Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair
June 2024
•Developed a magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating material structure with magnetic stimulation for spinal cord regeneration.•Demonstrated that medium-intensity magnetic...
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The role of Piezo1 and Piezo2 proteins in tissue engineering: A Comprehensive review
June 2024
•Piezo1 and Piezo2 are the two novel mechanosensitive ion channels found in humans.•Piezo's are a sizeable trimeric protein with a three-bladed, propeller-like structure.•Two models- ‘Force from filament’...
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Emerging microfluidics for the modeling and treatment of arthritis
June 2024
•Arthritis is a general term for a variety of joint diseases, seriously affecting people's physical and mental health.•Microfluidic is a technology that allows the precise control of fluid in a micro-channel.•In...
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Microalgae-based drug delivery system for tumor microenvironment photo-modulating and synergistic chemo-photodynamic therapy of osteosarcoma
June 2024
•A natural photosynthetic microalgae (C. vulgaris) was used as drug carriers loaded with chemotherapeutic doxorubicin to develop a multifunctional therapeutic platform (CV@DOX) for tumor microenvironment...
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Flexible wearable sensors: An emerging platform for monitoring of bacterial infection in skin wounds
June 2024
•We introduced the distribution of bacteria in wound infections.•We summarized current methods for bacterial detection in wounds.•We discussed three kinds of flexible wearable sensors for bacterial...
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Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction
June 2024
•Sequential delivery of cytokines, growth factors and cells improved cardiac tissue repair.•IL-10, TGF-β/VEGF-A, FGF-2 loaded into a chitosan-based cryogel exerted a synergistic effect.•Cryo/GF/Cells...
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The Role of Gut Microbiota associated Metabolites in Digestive Disorders
Available online 16 April 2024
•Gut microbiota is closely linked to the body through its metabolites.•Gut microbiota metabolites participate in digestive system stabilization.•Gut microbiota metabolites affect the inflammatory bowel...
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Sustained Adenosine Release: Revealing its Impact on Osteogenic Signalling Pathways of Human Mesenchymal Stromal Cells
Available online 12 April 2024
•Sustained adenosine release achieved using s/o/w method in polymeric microparticles•Controlled release of adenosine boosts mineralization & osteogenic differentiation•Novel exploration of adenosine's...
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Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
Available online 9 April 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
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Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis
March 2024
•It is a huge challenge to one-step repair the load-bearing large segmental bone defects due to the insufficient structural stability of Ca-phosphate bioceramics.•Customized magnesium-doped wollastonite/β-TCP...
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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering
March 2024
•This review outlined hierarchical structures of bone matrix spanning from nanoscale to macroscale.•This study discussed materialistic components of scaffolds and featured scaffold strategies.•This...
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Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour
March 2024
•Tanycte-derived stem/progenitor cells cultured in vitro spontaneously differentiate.•Fiber properties can be controlled during manufacture to introduce aligned fibers.•Tanycyte-derived neurospheres...
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PETG: Applications in Modern Medicine
March 2024
•PETG is a miscible, transparent thermoplastic with strong tensile properties, high ductility, and favorable resistance to heat and chemical insults.•PETG is an inexpensive and versatile biomaterial.•3D...
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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure
March 2024
•The fully human tissue-derived adhesive materials enable significant suppression of inflammatory cytokine storms, which breaks the limitations of existing strategies for organ repair based on the molecular...
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Applications of silk-based biomaterials in biomedicine and biotechnology
March 2024
•Here, we reported the various unique properties of silk and commercially available silk-based biomaterials.•This review focused on highlighting various biomedical applications of silk-based biomaterials...
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Microenvironment-responsive nanosystems for osteoarthritis therapy
March 2024
•This review underscores the intricate nature of OA, and emphasizes the challenge of comprehending its pathogenesis which have hindered the development of targeted therapies and precision medicine for...
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Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages
March 2024
•We applied pulsed electromagnetic field (PEMF) stimulation on nerve cells.•We screened different parameters and found the optimal ones to improve neurite outgrowth.•The same parameters had anti-inflammatory...
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Modelling the development of biological structures displaying longitudinal geometries in vitro: culturing pluripotent stem cells on plasma-treated, growth factor-coupled polycaprolactone fibres
March 2024
•We have taken a biomimicry approach to generate complex longitudinal structures in vitro using pluripotent stem cells cultured on plasma-immersion ion implantation (PIII)-treated polycaprolactone (PCL)...
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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency
March 2024
•Simplified process: The AgSNP@CD was prepared through a simplified process, making it amenable to large-scale production.•Portable and stroage: AgSNP@CD maintains structural integrity after compression,...
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Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
Available online 5 March 2024
•Our previous studies have demonstrated the potential of paris saponins II in mitigating neutrophil infiltration in the nasal mucosa of AR mice. However, its clinical applicability has been hampered...
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Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
Available online 1 February 2024
•The mechanism of osteoclastogenesis induced by rankl is very important.•Oleandin can inhibit RANKL-induced osteoclast formation and bone resorption in vitro•Oleandrin effectively inhibited lipopolysaccharide-induced...
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Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres
Available online 24 January 2024
•The effect of strain on muscle tendon junction formation was investigated for the first time.•10 % cyclic strain induced the cell morphology changes and the gene expression and production of proteins...
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Cross-talk between biometal ions and immune cells for bone repair
Available online 17 January 2024
•The interplay between bioactive factors, bone-related cells, and immune system involved in bone repair continues to be of great scientific interest in the field of bone tissue regeneration.•In this...
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Microalgae-based drug delivery systems in biomedical applications
Available online 15 January 2024
•Applications of microalgae biomass as drug carrier.•Microalgae drug delivery systems based on simple preparation and surface modifying.•Applications of photosynthesis in microalgae as an oxygenator.•Applications...
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In inflammatory bowel disease and extraintestinal manifestations: What role does microbiome play?
December 2023
•This review aims at conveying the roles of microbiome in inflammatory bowel disease and extraintestinal manifestations.•A critical analysis of current development and challenges is presented.•A comprehensive...
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