Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Available online 19 April 2024
The Lon proteases are evolutionarily conserved oligomeric hydrolases characterized by a built-in ATPase module. Here, we report the structures of LonC from Meiothermus taiwanensis (MtaLonC), a unique...
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Coordination of genome stability: Novel communication pathways between chloroplasts and other compartments in plant cells
Available online 18 April 2024
Chloroplasts have their own genomes, as do the nucleus and mitochondria. Coordination between these genomic compartments in plant cells is crucial for plant development and adaptation to the environment....
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The Application of Multi-scale Simulation in Advanced Electronic Packaging
Available online 16 April 2024
•This review systematically summarized the multiphysics simulation technology for electronic packaging.•This review highlighted the challenges and potential methods for modeling and solving coupled...
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Exploration of ultrafast dynamic processes in photocatalysis: advances and challenges
Available online 16 April 2024
Photocatalysis plays a crucial role in harnessing renewable energy by efficiently converting solar energy into chemical energy. Adequate cognition of photogenerated charge carrier dynamics in photocatalysis...
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Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review
Available online 16 April 2024
Brain-computer interface (BCI) technology represents a burgeoning interdisciplinary domain that facilitates direct communication between individuals and external devices. The efficacy of BCI systems...
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The application of antibody-based agents in cancer therapy based on their mechanisms of action
Available online 15 April 2024
Monoclonal antibodies and antibody-based agents are undergoing remarkable development in cancer immunotherapy. Based on their structural components, these antibodies mediate the crosslinking of tumor...
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Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression
Available online 15 April 2024
The Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is a non-receptor tyrosine phosphatase and acts as a convergent node for oncogenic cell-signaling cascades. SHP2 has been recognized...
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Engineering Exosomes and Exosome-like Nanovesicles for Improving Tissue Targeting and Retention
Available online 12 April 2024
Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological...
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Mechanical communication and function regulation of immune cells
Available online 12 April 2024
As the pivotal components of the immune system, immune cells can migrate rapidly and with flexibility to fulfill their critical functions. The cytoskeleton and mechano-sensitive proteins anchored within...
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Revealing the intricate mechanism governing the pH-dependent activity of a quintessential representative of flavoproteins, glucose oxidase
Available online 12 April 2024
Glucose oxidase (Gox), a prototypical flavoprotein, exhibits diverse industrial applications in glucose sensing and gluconic acid production. Its enzymatic activity is pH-dependent, with maximum activity...
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Neuromodulation with chemicals: Opportunities and challenges
Available online 12 April 2024
Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to...
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Fine-Tune the Electronic Structure of Copper Nanowire Networks by Heteroatom Doping Toward Enhanced Fenton-like Reaction
Available online 11 April 2024
To fine-tune the configuration of electrons around metal centers is critical to enhancing the activation of peroxymonosulfate (PMS) for organic decontamination in a manner similar to the Fenton-like...
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Selective Oxidation by TS-1 coupled with in-situ Synthesised H2O2
Available online 10 April 2024
Feedstock valorisation with preformed H2O2 in conjunction with titanosilicate zeotypes is particularly attractive due to the increased selectivity, lower operating temperatures and improved process...
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New horizon of in-situ Raman spectroelectrochemistry on single-crystal surfaces
Available online 10 April 2024
Single crystal electrodes possess highly ordered and well-defined surface structures, making them ideal model systems for studying the mechanism of electrocatalytic reactions. The latest advancements...
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Characteristic and mechanism of pollution by laser cleaning high-value vehicle parts with a complex structure in remanufacturing industry
Available online 10 April 2024
Remanufacturing high-value vehicle parts is of substantial significance for the circular economy because it provides a second service life and reduces solid waste generation. Laser cleaning is a promising...
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DNA-based Hydrogels: Ideal Biomaterials for Cartilage Organoids
Available online 10 April 2024
•Using cartilage organoids is expected to be an effective treatment of osteoarthritis.•We first proposed to construct cartilage organoids by using DNA hydrogel.•DNA hydrogel can replace Matrigel to...
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A commentary of “Novel approaches in precise genome manipulations from single nucleotides to large DNA segments”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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A commentary of “Discovery of a new charge storage and collective reaction mechanism in lithium sulfur batteries”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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Engineering Exosomes and Exosome-like Nanovesicles for Improving Targeted Retention
Available online 10 April 2024
Exosomes are natural nano-size particles secreted by cells of the human, containing a variety of bioactive cargos. Serve as crucial mediators of intercellular communication, exosomes are involved in...
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Integrating multi-omics data of childhood asthma using a deep association model
Available online 2 April 2024
Childhood asthma is one of the most common respiratory diseases with rising mortality and morbidity. The multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding...
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A commentary of “Rhythmic cilia changes support SCN neuron coherence in circadian clock”: Top 10 Scientific Advances of 2023, China
Available online 2 April 2024
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The SoxE factor Sox9 is selectively expressed in indirect pathway striatal projection neurons and regulates synaptogenesis
Available online 2 April 2024
Striatum, as the largest structure of the basal ganglia, serves as a center for information transmission and is critical for motor function and reward perception. However, the genetic mechanisms underlying...
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A Review on Aero-Engine Inlet-Compressor Integration and Inlet Flow Distortion in Axial Compressors
Available online 1 April 2024
The air intake-compression systems of modern aircraft usually use the aero-engine intake and fan/compressor as the main components. Inlet-engine compatibility has always been the key to the stable and...
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Molecular biology of targeting lymphangiogenesis in cancer: therapeutic strategies and future promise
Available online 1 April 2024
Lymphangiogenesis is considered the rate-limiting step for tumor lymph node (LN) metastasis by sprouting the new lymphatic network from preexisting lymphatic vessels to favor the invasion and entry...
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A novel ABC family protein participates in the regulation of fitness cost caused by tet(X4)-bearing plasmids in Escherichia coli
Available online 1 April 2024
The worldwide prevalence of the plasmid-mediated tigecycline resistance gene tet(X4) in diverse bacterial species challenges the clinical application of tigecycline and poses an increasing threat to...
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