A commentary of “Novel approaches in precise genome manipulations from single nucleotides to large DNA segments”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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A commentary of “Discovery of a new charge storage and collective reaction mechanism in lithium sulfur batteries”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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Integrating multi-omics data of childhood asthma using a deep association model
Available online 2 April 2024
Childhood asthma is one of the most common respiratory diseases with rising mortality and morbidity. The multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding...
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A commentary of “Rhythmic cilia changes support SCN neuron coherence in circadian clock”: Top 10 Scientific Advances of 2023, China
Available online 2 April 2024
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The SoxE factor Sox9 is selectively expressed in indirect pathway striatal projection neurons and regulates synaptogenesis
Available online 2 April 2024
Striatum, as the largest structure of the basal ganglia, serves as a center for information transmission and is critical for motor function and reward perception. However, the genetic mechanisms underlying...
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A Review on Aero-Engine Inlet-Compressor Integration and Inlet Flow Distortion in Axial Compressors
Available online 1 April 2024
The air intake-compression systems of modern aircraft usually use the aero-engine intake and fan/compressor as the main components. Inlet-engine compatibility has always been the key to the stable and...
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Molecular biology of targeting lymphangiogenesis in cancer: therapeutic strategies and future promise
Available online 1 April 2024
Lymphangiogenesis is considered the rate-limiting step for tumor lymph node (LN) metastasis by sprouting the new lymphatic network from preexisting lymphatic vessels to favor the invasion and entry...
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A novel ABC family protein participates in the regulation of fitness cost caused by tet(X4)-bearing plasmids in Escherichia coli
Available online 1 April 2024
The worldwide prevalence of the plasmid-mediated tigecycline resistance gene tet(X4) in diverse bacterial species challenges the clinical application of tigecycline and poses an increasing threat to...
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The impacts of gradually terminating nonpharmaceutical interventions for SARS-CoV-2: A mathematical modelling analysis
March 2024
With the expansion of vaccination programs, the policy of terminating nonpharmaceutical interventions for preventing the SARS-CoV-2 pandemic should become more flexible. The current study investigated...
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Frontiers and future perspectives of neuroimmunology
March 2024
Neuroimmunology is an interdisciplinary branch of biomedical science that emerges from the intersection of studies on the nervous system and the immune system. The complex interplay between the two...
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Flexible bidirectional self-powered photodetector with significantly reduced volume and accelerated response speed based on hydrogel and lift-off GaN-based nanowires
March 2024
•A flexible bidirectional detector is realized by nanowires and hydrogel.•The detector volume is reduced successfully from ∼482 to only 0.18 cm3.•Break the limitation to wear bidirectional photoelectrochemical...
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Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders
March 2024
Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis. Genetic defects in microglia lead to microglial...
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Characterization of sand convective motions at a vertical wall subjected to long-term cyclic loading
March 2024
By conducting a two-dimensional experimental study, this paper aims to enhance the understanding of the mechanism of sand convective motions in the vicinity of a wall subjected to long-term cyclic lateral...
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The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases
March 2024
According to a study from World Health Organization's Global Burden of Disease, mental and neurological disorders have accounted for 13% of global diseases in recent years and are on the rise. Neuropsychiatric...
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Fibroblasts: New players in the central nervous system?
March 2024
Fibroblasts are typically described as cells that produce extracellular matrix, contribute to the formation of connective tissue, and maintain the structural framework of tissues. Fibroblasts are the...
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The top-order energy of quasilinear wave equations in two space dimensions is uniformly bounded
March 2024
Alinhac solved a long-standing open problem in 2001 and established that quasilinear wave equations in two space dimensions with quadratic null nonlinearities admit global-in-time solutions, provided...
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Meningeal lymphatic vasculature, a general target for glioblastoma therapy?
March 2024
Glioblastoma (GBM) causes nearly universal mortality as a result of the failure of conventional therapies including surgical resection, targeted radiation therapy, and chemotherapy. An increasingly...
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Scavenging and release of REE and HFSE by Na-metasomatism in magmatic-hydrothermal systems
March 2024
Exploitable or potentially exploitable deposits of critical metals, such as rare-earth (REE) and high-field-strength elements (HFSE), are commonly associated with alkaline or peralkaline igneous rocks....
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Market-based solution in China to finance the clean from the dirty
March 2024
Financial incentives play a key role in promoting renewable energy investments that can help China achieve the ‘dual carbon’ goal. The national emissions trading scheme (ETS) and the renewable energy...
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Quantitative analysis of the morphing wing mechanism of raptors: Analysis methods, folding motions, and bionic design of Falco Peregrinus
March 2024
Raptors can change the shape and area of their wings to an exceptional degree in a fast and efficient manner, surpassing other birds, insects, or bats. Some researchers have focused on the functional...
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Stretchable poly[2]rotaxane elastomers
March 2024
Mechanically interlocked polymers (MIPs) are promising candidates for the construction of elastomeric materials with desirable mechanical performance on account of their abilities to undergo inherent...
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2.4 V ultrahigh-voltage aqueous MXene-based asymmetric micro-supercapacitors with high volumetric energy density toward a self-sufficient integrated microsystem
March 2024
Two-dimensional MXenes are key high-capacitance electrode materials for micro-supercapacitors (MSCs) catering to integrated microsystems. However, the narrow electrochemical voltage windows of conventional...
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Skull and vertebral bone marrow in central nervous system inflammation
March 2024
Emerging evidence has highlighted the capacity of hematogenous cells in skull and vertebral bone marrow to enter the meningeal borders via ossified vascular channels and maintain immune homeostasis...
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