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Most Downloaded Non-coding RNA Research Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Long non-coding RNAs: Mechanism of action and functional utility

October 2016
Shakil Ahmad Bhat | Syed Mudasir Ahmad | Peerzada Tajamul Mumtaz | Abrar Ahad Malik | Mashooq Ahmad Dar | Uneeb Urwat | Riaz Ahmad Shah | Nazir Ahmad Ganai

Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...

2. Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

3. Circular RNA expression and function in the brain

March 2019
Shobana Sekar | Winnie S. Liang

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for...

4. Long non-coding RNAs: Functional regulatory players in breast cancer

March 2019
Rana Ahmed Youness | Mohamed Zakaria Gad

Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional...

5. Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

6. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

7. Long non-coding RNAs in the failing heart and vasculature

September 2018
Steffie Hermans-Beijnsberger | Marc van Bilsen | Blanche Schroen

Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function...

8. Non-coding RNA regulation in reproduction: Their potential use as biomarkers

June 2019
Vanesa Robles | David G. Valcarce | Marta F. Riesco

Non-coding RNAs (ncRNAs) are crucial regulatory elements in most biological processes and reproduction is also controlled by them. The different types of ncRNAs, as well as the high complexity of these...

9. Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis

June 2018
Jameel M. Abduljalil

Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or...

10. Circular RNAs in the cardiovascular system

March 2018
Clarissa P.C. Gomes | Antonio Salgado-Somoza | Esther E. Creemers | Christoph Dieterich | Mitja Lustrek | Yvan Devaux

Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding...

11. Dietary non-coding RNAs from plants: Fairy tale or treasure?

June 2019
Gopinath M. Sundaram

The past two decades have witnessed soaring interest in the field of non-coding RNAs, largely attributed by its regulatory role in controlling two third of human transcriptional output. Though, there...

12. C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks

June 2019
Stefan Stamm | J. Stephen Lodmell

C/D box snoRNAs (SNORDs) are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate...

13. Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics

March 2019
Elisa De Paola | Veronica Verdile | Maria Paola Paronetto

In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases....

14. miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

March 2019
Valérie Metzinger-Le Meuth | Laurent Metzinger

microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded...

15. On a stake-out: Mycobacterial small RNA identification and regulation

September 2019
Sagarika Taneja | Tanmay Dutta

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their survival in the...

16. Current role of non-coding RNAs in the clinical setting

September 2019
Caterina Vicentini | Francesca Galuppini | Vincenzo Corbo | Matteo Fassan

Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and...

17. Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

December 2018
Andrew G.L. Douglas

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense...

18. Molecular functions and specific roles of circRNAs in the cardiovascular system

June 2018
Lesca M. Holdt | Alexander Kohlmaier | Daniel Teupser

As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge...

19. Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart

March 2018
F. De Majo | M. Calore

Epigenetics refers to all the changes in phenotype and gene expression which are not due to alterations in the DNA sequence. These mechanisms have a pivotal role not only in the development but also...

20. Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways

December 2019
Gabriel Pisani | Byron Baron

The nucleus is an essential hub for the regulation of gene expression in both spatial and temporal contexts. The complexity required to manage such a feat has resulted in the evolution of multiple sub-structures...

21. Relations between approved platinum drugs and non-coding RNAs in mesothelioma

December 2018
Bernhard Biersack

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically...

22. A novel enhancer RNA, Hmrhl, positively regulates its host gene, phkb, in chronic myelogenous leukemia

September 2019
Roshan Fatima | Subhendu Roy Choudhury | Divya T.R | Utsa Bhaduri | M.R.S. Rao

Noncoding RNAs are increasingly being accredited with key roles in gene regulation during development and disease. Here we report the discovery and characterization of a novel long noncoding RNA, Hmrhl,...

23. Unraveling long non-coding RNAs through analysis of high-throughput RNA-sequencing data

June 2017
Rashmi Tripathi | Pavan Chakraborty | Pritish Kumar Varadwaj

Extensive genome-wide transcriptome study mediated by high throughput sequencing technique has revolutionized the study of genetics and epigenetic at unprecedented resolution. The research has revealed...

24. Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation

September 2019
Zainularifeen Abduljaleel

Oxidative damaged DNA base lesions are repaired through human 8-oxoguanine DNA glycosylase gene (hOGG1) mediated pathways. A recent report based on the meta-analysis has suggested that the DNA Repair...

25. Non-coding RNA influences in dementia

December 2018
Duncan Ayers | Charles Scerri

Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other...

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