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Most Downloaded Non-coding RNA Research Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. RNA and liquid-liquid phase separation

June 2021
Qi Guo | Xiangmin Shi | Xiangting Wang

Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...

2. Long non-coding RNAs: Mechanism of action and functional utility

October 2016
Shakil Ahmad Bhat | Syed Mudasir Ahmad | Peerzada Tajamul Mumtaz | Abrar Ahad Malik | Mashooq Ahmad Dar | Uneeb Urwat | Riaz Ahmad Shah | Nazir Ahmad Ganai

Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...

3. Long non-coding RNAs in oncourology

September 2021
Ilgiz Gareev | Yulia Gileva | Aleksandr Dzidzaria | Ozal Beylerli | Valentin Pavlov | Murad Agaverdiev | Bakhodur Mazorov | Ilfat Biganyakov | Andranik Vardikyan | Mei Jin | Aamir Ahmad

For several decades, research in tumor biology has focused on the involvement of genes encoding a protein. Only recently has it been discovered that a whole class of molecules called non-coding RNAs...

4. Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy

December 2020
Ahmedz Widiasta | Yunia Sribudiani | Husna Nugrahapraja | Dany Hilmanto | Nanan Sekarwana | Dedi Rachmadi

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease (COVID-19), potentially have severe kidney adverse effects. This organ expressed angiotensin-converting...

5. Involvement of noncoding RNA in blood-brain barrier integrity in central nervous system disease

September 2021
Xi Liu | Ling Shen | Bing Han | Honghong Yao

Given the important role of the blood-brain barrier (BBB) in the central nervous system (CNS), increasing studies have been carried out to determine how the structural and functional integrity of the...

6. Characteristics of miRNA-SNPs in healthy Japanese subjects and non-small cell lung cancer, colorectal cancer, and soft tissue sarcoma patients

September 2021
Koki Katayama | Shimon Nakashima | Hiroo Ishida | Yutaro Kubota | Masataka Nakano | Tatsuki Fukami | Yasutsuna Sasaki | Ken-ichi Fujita | Miki Nakajima

Single nucleotide polymorphisms in genes encoding microRNAs (miRNA-SNPs) may affect the maturation steps of miRNAs or target mRNA recognition, leading to changes in the expression of target mRNAs to...

7. High affinity of host human microRNAs to SARS-CoV-2 genome: An in silico analysis

December 2020
Saeideh Jafarinejad-Farsangi | Maryam Moazzam Jazi | Farzaneh Rostamzadeh | Morteza Hadizadeh

Coronavirus disease 2019 (COVID-19) caused by a novel betacoronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted top health concerns worldwide within a few months...

8. Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

9. The nuclear functions of long noncoding RNAs come into focus

June 2021
Zhenxing Song | Jiamei Lin | Zhengguo Li | Chuan Huang

Long noncoding RNAs (lncRNAs), defined as untranslated and tightly-regulated transcripts with a length exceeding 200 nt, are common outputs of the eukaryotic genome. It is becoming increasingly apparent...

10. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

11. Differential non-coding RNAs expression profiles of invasive and non-invasive pituitary adenomas

September 2021
Ozal Beylerli | Dinar Khasanov | Ilgiz Gareev | Elvir Valitov | Andrei Sokhatskii | Chunlei Wang | Valentin Pavlov | Guzel Khasanova | Aamir Ahmad

Pituitary adenoma (PA) accounts for 10–15% of all intracranial neoplasms. Despite their benign nature, PA often shows invasive growth. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are a class...

12. Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

13. Oocyte specific lncRNA variant Rose influences oocyte and embryo development

June 2021
Rajan Iyyappan | Daria Aleshkina | Linkai Zhu | Zongliang Jiang | Veronika Kinterova | Andrej Susor

Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain...

14. In silico identification and validation of miRNA and their DIR specific targets in Oryza sativa Indica under abiotic stress

December 2020
Deepak Kumar Singh | Shourya Mehra | Sayan Chatterjee | Ram Singh Purty

Several biotic (bacterial and viral pathogenesis) and abiotic stress factors like salt, drought, cold, and extreme temperatures significantly reduce crop productivity and grain quality throughout the...

15. miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway

June 2021
Ermin Rachmawati | Djanggan Sargowo | M. Saifur Rohman | Nashi Widodo | Umi Kalsum

MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using...

16. MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions

March 2020
Aisha M. ElKhouly | R.A. Youness | M.Z. Gad

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration...

17. Long non-coding RNAs in breast cancer metastasis

December 2020
Priya Mondal | Syed Musthapa Meeran

Breast cancer is the leading cause of cancer-related death among women. Recurrence of primary tumor and metastasis to distant body parts are major causes of breast cancer-associated mortality. The 5-year...

18. Green pesticide: Tapping to the promising roles of plant secreted small RNAs and responses towards extracellular DNA

March 2021
Karlia Meitha | Rizkita Rachmi Esyanti | Iriawati | Ristag Hamida Hanisia | Rohyani

The diverse roles of non-coding RNA and DNA in cross-species communication is yet to be revealed. Once thought to only involve intra-specifically in regulating gene expression, the evidence that these...

19. The physiological function of long-noncoding RNAs

December 2020
He Chen | Ge Shan

The physiological processes of cells and organisms are regulated by various biological macromolecules, including long-noncoding RNAs (lncRNAs), which cannot be translated into protein and are different...

20. Role of let-7 family microRNA in breast cancer

October 2016
Chadrashekar Kagepura Thammaiah | Shankar Jayaram

Metastasis and resistance to therapy significantly contribute to cancer-related deaths. Growing body of evidence suggest that altered expression of microRNAs (miRNAs) is one of the root cause of adverse...

21. Genome-wide analysis of PHD finger gene family and identification of potential miRNA and their PHD finger gene specific targets in Oryza sativa indica

December 2020
Aafrin Waziri | Deepak Kumar Singh | Tarun Sharma | Sayan Chatterjee | Ram Singh Purty

Rice (Oryza sativa L.) is one of the most important cereal crops for one third of the world population. However, the grain quality as well as yield of rice is severely affected by various abiotic stresses....

22. Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia

June 2021
Guannan Du | Yunan Zhang | Shoushan Hu | Xueer Zhou | Yi Li

Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes...

23. Role of miRNAs and lncRNAs in hematopoietic stem cell differentiation

March 2021
Soudeh Ghafouri-Fard | Vahid Niazi | Mohammad Taheri

Non-coding RNAs (ncRNAs) have diverse roles in the differentiation of hematopoietic cells. Among these transcripts, long ncRNAs (lncRNAs) and microRNAs (miRNAs) have especial contribution in this regard...

24. Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways

December 2019
Gabriel Pisani | Byron Baron

The nucleus is an essential hub for the regulation of gene expression in both spatial and temporal contexts. The complexity required to manage such a feat has resulted in the evolution of multiple sub-structures...

25. A bioinformatics approach to identify novel long, non-coding RNAs in breast cancer cell lines from an existing RNA-sequencing dataset

June 2020
Oza Zaheed | Julia Samson | Kellie Dean

Breast cancer research has traditionally centred on genomic alterations, hormone receptor status and changes in cancer-related proteins to provide new avenues for targeted therapies. Due to advances...

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