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Most Downloaded Non-coding RNA Research Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Long non-coding RNAs: Mechanism of action and functional utility

October 2016
Shakil Ahmad Bhat | Syed Mudasir Ahmad | Peerzada Tajamul Mumtaz | Abrar Ahad Malik | Mashooq Ahmad Dar | Uneeb Urwat | Riaz Ahmad Shah | Nazir Ahmad Ganai

Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...

2. MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions

March 2020
Aisha M. ElKhouly | R.A. Youness | M.Z. Gad

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration...

3. Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

4. Circular RNA expression and function in the brain

March 2019
Shobana Sekar | Winnie S. Liang

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for...

5. Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways

December 2019
Gabriel Pisani | Byron Baron

The nucleus is an essential hub for the regulation of gene expression in both spatial and temporal contexts. The complexity required to manage such a feat has resulted in the evolution of multiple sub-structures...

6. On a stake-out: Mycobacterial small RNA identification and regulation

September 2019
Sagarika Taneja | Tanmay Dutta

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their survival in the...

7. Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

8. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

9. Unravelling the role of long non-coding RNA - LINC01087 in breast cancer

March 2020
Rashmi Tripathi | Imlimaong Aier | Pavan Chakraborty | Pritish Kumar Varadwaj

Apoptosis is a ‘programmed fate’ of all cells participating in diverse physiological and pathological conditions. The role of critical regulators and their involvement in this complex multi-stage process...

10. Current role of non-coding RNAs in the clinical setting

September 2019
Caterina Vicentini | Francesca Galuppini | Vincenzo Corbo | Matteo Fassan

Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and...

11. Long non-coding RNAs: Functional regulatory players in breast cancer

March 2019
Rana Ahmed Youness | Mohamed Zakaria Gad

Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional...

12. Identification of novel microRNAs and their targets in Chlorophytum borivilianum by small RNA and degradome sequencing

December 2019
Monika Kajal | Nishant Kaushal | Ravneet kaur | Kashmir Singh

Plant specific miRNAs (Novel miRNAs) are well known to perform distinctive functions in biological processes. Identification of new miRNAs is necessary to understand their gene regulation. Degradome...

13. Dietary non-coding RNAs from plants: Fairy tale or treasure?

June 2019
Gopinath M. Sundaram

The past two decades have witnessed soaring interest in the field of non-coding RNAs, largely attributed by its regulatory role in controlling two third of human transcriptional output. Though, there...

14. Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome

December 2019
Zainularifeen Abduljaleel | Mohammad Athar | Faisal A. Al-Allaf | Saied Al-Dehlawi | Jose R. Vazquez

The human gene MUTYH codes for a DNA glycosylase involved in the repair of oxidative DNA damage. Faulty MUTYH protein activity causes the accumulation of G→T transversions due to unrepaired 8-oxoG:A...

15. A novel enhancer RNA, Hmrhl, positively regulates its host gene, phkb, in chronic myelogenous leukemia

September 2019
Roshan Fatima | Subhendu Roy Choudhury | Divya T.R | Utsa Bhaduri | M.R.S. Rao

Noncoding RNAs are increasingly being accredited with key roles in gene regulation during development and disease. Here we report the discovery and characterization of a novel long noncoding RNA, Hmrhl,...

16. Long non-coding RNAs in the failing heart and vasculature

September 2018
Steffie Hermans-Beijnsberger | Marc van Bilsen | Blanche Schroen

Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function...

17. C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks

June 2019
Stefan Stamm | J. Stephen Lodmell

C/D box snoRNAs (SNORDs) are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate...

18. Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics

March 2019
Elisa De Paola | Veronica Verdile | Maria Paola Paronetto

In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases....

19. Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

October 2016
Bernhard Biersack

The epigenetic regulation of cancer cells by small non-coding RNA molecules, the microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs play crucial roles concerning...

20. Relations between approved platinum drugs and non-coding RNAs in mesothelioma

December 2018
Bernhard Biersack

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically...

21. Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies: Hype or hope?

June 2018
Hetty Helsmoortel | Celine Everaert | Nicolaas Lumen | Piet Ost | Jo Vandesompele

Prostate cancer is a heterogeneous malignancy, with clinical courses widely differing between indolent and aggressive lethal disease. This heterogeneity calls for a more personalized approach towards...

22. Non-coding RNA regulation in reproduction: Their potential use as biomarkers

June 2019
Vanesa Robles | David G. Valcarce | Marta F. Riesco

Non-coding RNAs (ncRNAs) are crucial regulatory elements in most biological processes and reproduction is also controlled by them. The different types of ncRNAs, as well as the high complexity of these...

23. Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

December 2018
Andrew G.L. Douglas

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense...

24. Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation

September 2019
Zainularifeen Abduljaleel

Oxidative damaged DNA base lesions are repaired through human 8-oxoguanine DNA glycosylase gene (hOGG1) mediated pathways. A recent report based on the meta-analysis has suggested that the DNA Repair...

25. miR-223 and other miRNA's evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools

March 2019
Valérie Metzinger-Le Meuth | Laurent Metzinger

microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded...

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