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Most Downloaded Non-coding RNA Research Articles

The most downloaded articles from ScienceDirect in the last 90 days.

1. Long non-coding RNAs: Mechanism of action and functional utility

October 2016
Shakil Ahmad Bhat | Syed Mudasir Ahmad | Peerzada Tajamul Mumtaz | Abrar Ahad Malik | Mashooq Ahmad Dar | Uneeb Urwat | Riaz Ahmad Shah | Nazir Ahmad Ganai

Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...

2. Exploring the mechanisms behind long noncoding RNAs and cancer

September 2018
Maggie M. Balas | Aaron M. Johnson

Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant players in gene regulation. They are often differentially expressed and widely-associated with a majority of cancer...

3. A bioinformatics approach to identify novel long, non-coding RNAs in breast cancer cell lines from an existing RNA-sequencing dataset

June 2020
Oza Zaheed | Julia Samson | Kellie Dean

Breast cancer research has traditionally centred on genomic alterations, hormone receptor status and changes in cancer-related proteins to provide new avenues for targeted therapies. Due to advances...

4. Altered levels of MALAT1 and H19 derived from serum or serum exosomes associated with type-2 diabetes

June 2020
Vianet Argelia Tello-Flores | Adán Valladares-Salgado | Marco Antonio Ramírez-Vargas | Miguel Cruz | Oscar del-Moral-Hernández | José Ángel Cahua-Pablo | Mónica Ramírez | Daniel Hernández-Sotelo | Adakatia Armenta-Solis | Eugenia Flores-Alfaro

Environmental, genetic and epigenetic risk factors have been closely related to the development of type-2 diabetes (T2D). It has been reported that the expression in H19 and MALAT1 are related to metabolic...

5. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

December 2018
Haiyan An | Non G. Williams | Tatyana A. Shelkovnikova

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...

6. Unraveling long non-coding RNAs through analysis of high-throughput RNA-sequencing data

June 2017
Rashmi Tripathi | Pavan Chakraborty | Pritish Kumar Varadwaj

Extensive genome-wide transcriptome study mediated by high throughput sequencing technique has revolutionized the study of genetics and epigenetic at unprecedented resolution. The research has revealed...

7. Viral lncRNA: A regulatory molecule for controlling virus life cycle

March 2017
Ziqiang Wang | Yiwan Zhao | Yaou Zhang

Long non-coding RNAs (lncRNAs) are found not only in mammals but also in other organisms, including viruses. Recent findings suggest that lncRNAs play various regulatory roles in multiple major biological...

8. Differential expression analysis comparing EBV uninfected to infected human cell lines identifies induced non-micro small non-coding RNAs

March 2020
Lumbini I. Moss | Van S. Tompkins | Walter N. Moss

Epstein–Barr virus (EBV) is a ubiquitous human herpes virus, which is implicated in cancer and various autoimmune diseases. This study profiles non-micro small non-coding RNA expression changes induced...

9. The lncRNA ANRIL is down-regulated in peripheral blood of patients with periodontitis

June 2020
Leila Gholami | Soudeh Ghafouri-Fard | Sara Mirzajani | Shahram Arsang-Jang | Mohammad Taheri | Zahra Dehbani | Safoora Dehghani | Behzad Houshmand | Reza Amid | Arezou Sayad | Bahareh Shams

Long non-coding RNAs (lncRNAs) have crucial roles in lncRNAs in periodontal development and disorders of this tissue. A number of lncRNAs especially those regulating immune responses contribute in the...

10. Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

March 2019
Faisal A. Al-Allaf | Zainularifeen Abduljaleel | Mohammad Athar | Mohiuddin M. Taher | Wajahatullah Khan | Huseyin Mehmet | Mukaddes Colakogullari | Sophia Apostolidou | Brian Bigger | Simon Waddington | Charles Coutelle | Michael Themis | Mohammed N. Al-Ahdal | Futwan A. Al-Mohanna | Zuhair N. Al-Hassnan | Abdellatif Bouazzaoui

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript....

11. On a stake-out: Mycobacterial small RNA identification and regulation

September 2019
Sagarika Taneja | Tanmay Dutta

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their survival in the...

12. Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways

December 2019
Gabriel Pisani | Byron Baron

The nucleus is an essential hub for the regulation of gene expression in both spatial and temporal contexts. The complexity required to manage such a feat has resulted in the evolution of multiple sub-structures...

13. Long noncoding RNAs and their link to cancer

June 2020
Justine M. Grixti | Duncan Ayers

The central dogma of molecular biology, developed from the study of simple organisms such as Escherichia coli, has up until recently been that RNA functions mainly as an information intermediate between...

14. MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions

March 2020
Aisha M. ElKhouly | R.A. Youness | M.Z. Gad

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration...

15. Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs

June 2018
Vasiliki Zarkou | Alexandros Galaras | Antonis Giakountis | Pantelis Hatzis

The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway...

16. The role of microRNAs in ectopic pregnancy: A concise review

June 2020
Soudeh Ghafouri-Fard | Hamed Shoorei | Mohammad Taheri

Ectopic pregnancy (EP) is reported in about 1%–2% of pregnant females and is associated with mortality and morbidity. Several genetic and environmental factors might modulate occurrence of EP. Prediction...

17. C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks

June 2019
Stefan Stamm | J. Stephen Lodmell

C/D box snoRNAs (SNORDs) are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate...

18. Unravelling the role of long non-coding RNA - LINC01087 in breast cancer

March 2020
Rashmi Tripathi | Imlimaong Aier | Pavan Chakraborty | Pritish Kumar Varadwaj

Apoptosis is a ‘programmed fate’ of all cells participating in diverse physiological and pathological conditions. The role of critical regulators and their involvement in this complex multi-stage process...

19. Relations between approved platinum drugs and non-coding RNAs in mesothelioma

December 2018
Bernhard Biersack

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically...

20. Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

October 2016
Bernhard Biersack

The epigenetic regulation of cancer cells by small non-coding RNA molecules, the microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs play crucial roles concerning...

21. Non-coding RNAs in cancer diagnosis and therapy

October 2016
Mahmood Rasool | Arif Malik | Sara Zahid | Muhammad Abdul Basit Ashraf | Mahmood Husain Qazi | Muhammad Asif | Ahmad Zaheer | Muhammad Arshad | Amir Raza | Mohammad Sarwar Jamal

Cancer invasion involves a series of fundamental heterogeneous steps, with each step being distinct in its type regarding its dependence on various oncogenic pathways. Over the past few years, researchers...

22. Role of let-7 family microRNA in breast cancer

October 2016
Chadrashekar Kagepura Thammaiah | Shankar Jayaram

Metastasis and resistance to therapy significantly contribute to cancer-related deaths. Growing body of evidence suggest that altered expression of microRNAs (miRNAs) is one of the root cause of adverse...

23. Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

December 2018
Andrew G.L. Douglas

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense...

24. Non-coding RNA regulation in reproduction: Their potential use as biomarkers

June 2019
Vanesa Robles | David G. Valcarce | Marta F. Riesco

Non-coding RNAs (ncRNAs) are crucial regulatory elements in most biological processes and reproduction is also controlled by them. The different types of ncRNAs, as well as the high complexity of these...

25. Identification of novel microRNAs and their targets in Chlorophytum borivilianum by small RNA and degradome sequencing

December 2019
Monika Kajal | Nishant Kaushal | Ravneet kaur | Kashmir Singh

Plant specific miRNAs (Novel miRNAs) are well known to perform distinctive functions in biological processes. Identification of new miRNAs is necessary to understand their gene regulation. Degradome...

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