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Recent Non-coding RNA Research Articles

Recently published articles from Non-coding RNA Research.

A holistic miRNA-mRNA module discovery

December 2021
Ghada Shommo | Bruno Apolloni

The regulatory role of the Micro-RNAs (miRNAs) in the messenger RNAs (mRNAs) gene expression is well understood by the biologists since some decades, even though the delving into specific aspects is...

Hypoxia related long non-coding RNAs in ischemic stroke

December 2021
Jiawei Yao | Yiming Du | Junsi Liu | Ilgiz Gareev | Guang Yang | Xiaohui Kang | Xiaoxiong Wang | Ozal Beylerli | Xin Chen

With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA)...

Characteristics of miRNA-SNPs in healthy Japanese subjects and non-small cell lung cancer, colorectal cancer, and soft tissue sarcoma patients

September 2021
Koki Katayama | Shimon Nakashima | Hiroo Ishida | Yutaro Kubota | Masataka Nakano | Tatsuki Fukami | Yasutsuna Sasaki | Ken-ichi Fujita | Miki Nakajima

Single nucleotide polymorphisms in genes encoding microRNAs (miRNA-SNPs) may affect the maturation steps of miRNAs or target mRNA recognition, leading to changes in the expression of target mRNAs to...

Differential non-coding RNAs expression profiles of invasive and non-invasive pituitary adenomas

September 2021
Ozal Beylerli | Dinar Khasanov | Ilgiz Gareev | Elvir Valitov | Andrei Sokhatskii | Chunlei Wang | Valentin Pavlov | Guzel Khasanova | Aamir Ahmad

Pituitary adenoma (PA) accounts for 10–15% of all intracranial neoplasms. Despite their benign nature, PA often shows invasive growth. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are a class...

Involvement of noncoding RNA in blood-brain barrier integrity in central nervous system disease

September 2021
Xi Liu | Ling Shen | Bing Han | Honghong Yao

Given the important role of the blood-brain barrier (BBB) in the central nervous system (CNS), increasing studies have been carried out to determine how the structural and functional integrity of the...

Long non-coding RNAs in oncourology

September 2021
Ilgiz Gareev | Yulia Gileva | Aleksandr Dzidzaria | Ozal Beylerli | Valentin Pavlov | Murad Agaverdiev | Bakhodur Mazorov | Ilfat Biganyakov | Andranik Vardikyan | Mei Jin | Aamir Ahmad

For several decades, research in tumor biology has focused on the involvement of genes encoding a protein. Only recently has it been discovered that a whole class of molecules called non-coding RNAs...

MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN

September 2021
Xiaoxiang Guan | Yiwei Zhang | Ilgiz Gareev | Ozal Beylerli | Xinyuan Li | Guitian Lu | Lin Lv | Xin Hai

Ischemic stroke (IS) is a common and severe neurological disorder and is associated with high rates of mortality and morbidity. Inflammatory reaction in astrocytes is one of the important pathological...

The nuclear functions of long noncoding RNAs come into focus

June 2021
Zhenxing Song | Jiamei Lin | Zhengguo Li | Chuan Huang

Long noncoding RNAs (lncRNAs), defined as untranslated and tightly-regulated transcripts with a length exceeding 200 nt, are common outputs of the eukaryotic genome. It is becoming increasingly apparent...

Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia

June 2021
Guannan Du | Yunan Zhang | Shoushan Hu | Xueer Zhou | Yi Li

Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes...

LINC02688 and PP7080 as novel biomarkers in early diagnosis of gastric cancer

June 2021
Sadegh Fattahi | Novin Nikbakhsh | Hassan Taheri | Elham Ghadami | Mohammad Ranaee | Haleh Akhavan-Niaki

Despite considerable progress in gastric cancer screening, prevention, and treatment, it remains a major cause of morbidity and mortality worldwide. Due to late diagnosis of the disease, early potential...

RNA and liquid-liquid phase separation

June 2021
Qi Guo | Xiangmin Shi | Xiangting Wang

Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...

Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

June 2021
Ammad Ahmad Farooqi | Kapanova Gulnara | Auyezova Ardak Mukhanbetzhanovna | Ubaidilla Datkhayev | Abay Z. Kussainov | Aima Adylova

RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional...

Oocyte specific lncRNA variant Rose influences oocyte and embryo development

June 2021
Rajan Iyyappan | Daria Aleshkina | Linkai Zhu | Zongliang Jiang | Veronika Kinterova | Andrej Susor

Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain...

miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway

June 2021
Ermin Rachmawati | Djanggan Sargowo | M. Saifur Rohman | Nashi Widodo | Umi Kalsum

MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using...

Analysis of differential expression of hypoxia-inducible microRNA-210 gene targets in mild and severe preeclamptic patients

March 2021
Deeba S. Jairajpuri | Zainab H. Malalla | Sameh Sarray | Naeema Mahmood

Preeclampsia (PE) is a multi-system disorder that is specific to human pregnancy. Inadequate oxygenation of uterus and placenta is considered as one of the leading causes for the disease. MicroRNA-210(miR-210)...

miRNA expression and interaction with the 3′UTR of FMR1 in FRAXopathy pathogenesis

March 2021
Alexander A. Dolskiy | Andrey A. Yarushkin | Irina V. Grishchenko | Natalya A. Lemskaya | Alexey V. Pindyurin | Lidiya V. Boldyreva | Vladimir O. Pustylnyak | Dmitry V. Yudkin

FRAXopathies are caused by the expansion of the CGG repeat in the 5′UTR of the FMR1 gene, which encodes the protein responsible for the synthesis of FMRP. This mutation leads to dramatic changes in...

Differences of time-dependent microRNA expressions in breast cancer cells

March 2021
Serife Buket Bozkurt | Bahadir Ozturk | Nadir Kocak | Ali Unlu

MicroRNA (miRNA) expression is a dynamic process in the cell, and the proper time period for post-transcriptional regulation might be critical due to the gene-on/-off expression times of the cell. Here,...

Role of miRNAs and lncRNAs in hematopoietic stem cell differentiation

March 2021
Soudeh Ghafouri-Fard | Vahid Niazi | Mohammad Taheri

Non-coding RNAs (ncRNAs) have diverse roles in the differentiation of hematopoietic cells. Among these transcripts, long ncRNAs (lncRNAs) and microRNAs (miRNAs) have especial contribution in this regard...

Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology

March 2021
Aima Adylova | Auyezova Ardak Mukhanbetzhanovna | Rukset Attar | Ishmuratova Margarita Yulaevna | Ammad Ahmad Farooqi

One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally...

Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA

March 2021
Ammad Ahmad Farooqi | Auyezova Ardak Mukhanbetzhanovna | Seher Yilmaz | Lazzat Karasholakova | Ishmuratova Margarita Yulaevna

Discovery of non-coding RNAs has paradigmatically shifted our understanding of the multifaceted nature of cancer. It is becoming progressively more understandable that long non-coding RNAs play fundamental...

Green pesticide: Tapping to the promising roles of plant secreted small RNAs and responses towards extracellular DNA

March 2021
Karlia Meitha | Rizkita Rachmi Esyanti | Iriawati | Ristag Hamida Hanisia | Rohyani

The diverse roles of non-coding RNA and DNA in cross-species communication is yet to be revealed. Once thought to only involve intra-specifically in regulating gene expression, the evidence that these...

MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis

March 2021
Noha A. Rezk | Mohamad Bakry Lashin | Norhan A. Sabbah

The role of the Sirutin 1 (SIRT1) and MicroRNA-34 a (miR-34a) in endometriosis and the extent to which the miR-34a/SIRT1/p53 signaling pathway is involved in its pathogenesis is unclear, so we aimed...

Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy

December 2020
Ahmedz Widiasta | Yunia Sribudiani | Husna Nugrahapraja | Dany Hilmanto | Nanan Sekarwana | Dedi Rachmadi

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease (COVID-19), potentially have severe kidney adverse effects. This organ expressed angiotensin-converting...

The physiological function of long-noncoding RNAs

December 2020
He Chen | Ge Shan

The physiological processes of cells and organisms are regulated by various biological macromolecules, including long-noncoding RNAs (lncRNAs), which cannot be translated into protein and are different...

In silico identification and validation of miRNA and their DIR specific targets in Oryza sativa Indica under abiotic stress

December 2020
Deepak Kumar Singh | Shourya Mehra | Sayan Chatterjee | Ram Singh Purty

Several biotic (bacterial and viral pathogenesis) and abiotic stress factors like salt, drought, cold, and extreme temperatures significantly reduce crop productivity and grain quality throughout the...

miRNA signature associated with R–CHOP refractoriness in patients diagnosed with diffuse large B cell lymphoma

December 2020
Oscar Raul Fajardo-Ramirez | Luis Villela | Jocelyn Nikita Campa-Carranza | Antonio Ali Perez-Maya | Gissela Borrego-Soto | Martin Ivan Wah-Suarez | Iram Pablo Rodríguez-Sánchez | Patricio A. Zapata-Morin | Rocio Ortiz-Lopez | Victor Manuel Treviño | Mariano Garcia-Magariño | Ivan Alberto Marino-Martinez

Refractoriness remains as one of the challenges in patients with lymphoma under chemotherapy, and among biological regulators in cells driving this type of response are microRNAs (miRNAs). Different...

Genome-wide analysis of PHD finger gene family and identification of potential miRNA and their PHD finger gene specific targets in Oryza sativa indica

December 2020
Aafrin Waziri | Deepak Kumar Singh | Tarun Sharma | Sayan Chatterjee | Ram Singh Purty

Rice (Oryza sativa L.) is one of the most important cereal crops for one third of the world population. However, the grain quality as well as yield of rice is severely affected by various abiotic stresses....

MicroRNA-7-5p′s role in the O-GlcNAcylation and cancer metabolism

December 2020
Sin Yung Woo | Su Yel Lee | Seong-Lan Yu | Se Jin Park | Daeun Kang | Jin Suk Kim | In Beom Jeong | Sun Jung Kwon | Wan Jin Hwang | Chang Ryul Park | Ji Woong Son

O-GlcNAc Transferase (OGT) is a complementary enzyme that regulates O-linked N-acetylglucosaminylation(O-GlcNAcylation) and plays a critical role in various cancer phenotypes, including invasion, migration,...

Long non-coding RNAs in breast cancer metastasis

December 2020
Priya Mondal | Syed Musthapa Meeran

Breast cancer is the leading cause of cancer-related death among women. Recurrence of primary tumor and metastasis to distant body parts are major causes of breast cancer-associated mortality. The 5-year...

High affinity of host human microRNAs to SARS-CoV-2 genome: An in silico analysis

December 2020
Saeideh Jafarinejad-Farsangi | Maryam Moazzam Jazi | Farzaneh Rostamzadeh | Morteza Hadizadeh

Coronavirus disease 2019 (COVID-19) caused by a novel betacoronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted top health concerns worldwide within a few months...

Evaluation of expression of vitamin D receptor related lncRNAs in lung cancer

September 2020
Tahereh Gheliji | Vahid Kholghi Oskooei | Asghar Ashrafi Hafez | Mohammad Taheri | Soudeh Ghafouri-Fard

Lung cancer as the most common cancer in the world is associated with high rate of mortality. Previous studies have detected expression of vitamin D receptor (VDR) in lung cancer tissues and reported...

The role of microRNAs in the pathogenesis of thyroid cancer

September 2020
Soudeh Ghafouri-Fard | Zeinab Shirvani-Farsani | Mohammad Taheri

Thyroid cancer is the most frequent type of cancers originating from the endocrine system. Early diagnosis leads to good clinical outcome in differentiated types of thyroid cancer. Yet, there are few...

The eminent roles of ncRNAs in the pathogenesis of psoriasis

September 2020
Soudeh Ghafouri-Fard | Reyhane Eghtedarian | Mohammad Taheri | Azadeh Rakhshan

Psoriasis is a chronic immune-related disorder in which both genetic and environmental parameters are involved. Recent studies have demonstrated dysregulation of long non-coding RNAs (lncRNAs) and microRNAs...

TINCR: An lncRNA with dual functions in the carcinogenesis process

September 2020
Soudeh Ghafouri-Fard | Sepideh Dashti | Mohammad Taheri | Mir Davood Omrani

Long non-coding RNAs (lncRNAs) have prominent roles in the pathogenesis of human cancers. Several studies have shown oncogenic or tumor suppressor roles of lncRNAs in different human tissues. Thus,...

Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer

September 2020
Shuping Liao | Xiaolan Lin | Changyu Mo

Diabetic foot ulcer (DFU) is a common and serious complication of diabetes mellitus, which influences patients’ quality of life. Recently, circRNA regulated the mRNA levels by functioning as miRNA sponge...

miRNA target prediction might explain the reduced transmission of SARS-CoV-2 in Jordan, Middle East

September 2020
Hazem Haddad | Walid Al-Zyoud

MicroRNAs (miRNAs) are non-coding RNAs that control many functions within the human cells by controlling protein levels through binding to messenger RNA (mRNA) translation process or mRNA abundance....

Circulating miR-216a as a biomarker of metabolic alterations and obesity in women

September 2020
Indira G.C. Vonhögen | Zenab Mohseni | Bjorn Winkens | Ke Xiao | Thomas Thum | Martina Calore | Paula A. da Costa Martins | Leon J. de Windt | Marc E.A. Spaanderman | Chahinda Ghossein-Doha

Obesity leads to an amplified risk of disease and contributes to the occurrence of type 2 diabetes, fatty liver disease, coronary heart disease, stroke, chronic kidney disease and various types of cancer....

The significance of microRNA deregulation in colorectal cancer development and the clinical uses as a diagnostic and prognostic biomarker and therapeutic agent

September 2020
Alireza Ahadi

Colorectal cancer (CRC) is one of the most widely recognized and deadly malignancies worldwide. Although death rates have declined over the previous decade, mainly because of enhanced screening or potential...

A bioinformatics approach to identify novel long, non-coding RNAs in breast cancer cell lines from an existing RNA-sequencing dataset

June 2020
Oza Zaheed | Julia Samson | Kellie Dean

Breast cancer research has traditionally centred on genomic alterations, hormone receptor status and changes in cancer-related proteins to provide new avenues for targeted therapies. Due to advances...

Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management?

June 2020
Joseph Nader | Laurent Metzinger | Pierre Maitrias | Thierry Caus | Valérie Metzinger-Le Meuth

Aortic valve stenosis remains the most frequent structural heart disease, especially in the elderly. During the last decade, we noticed an important consideration and a huge number of publications related...

Altered levels of MALAT1 and H19 derived from serum or serum exosomes associated with type-2 diabetes

June 2020
Vianet Argelia Tello-Flores | Adán Valladares-Salgado | Marco Antonio Ramírez-Vargas | Miguel Cruz | Oscar del-Moral-Hernández | José Ángel Cahua-Pablo | Mónica Ramírez | Daniel Hernández-Sotelo | Adakatia Armenta-Solis | Eugenia Flores-Alfaro

Environmental, genetic and epigenetic risk factors have been closely related to the development of type-2 diabetes (T2D). It has been reported that the expression in H19 and MALAT1 are related to metabolic...

The lncRNA ANRIL is down-regulated in peripheral blood of patients with periodontitis

June 2020
Leila Gholami | Soudeh Ghafouri-Fard | Sara Mirzajani | Shahram Arsang-Jang | Mohammad Taheri | Zahra Dehbani | Safoora Dehghani | Behzad Houshmand | Reza Amid | Arezou Sayad | Bahareh Shams

Long non-coding RNAs (lncRNAs) have crucial roles in lncRNAs in periodontal development and disorders of this tissue. A number of lncRNAs especially those regulating immune responses contribute in the...

The role of microRNAs in ectopic pregnancy: A concise review

June 2020
Soudeh Ghafouri-Fard | Hamed Shoorei | Mohammad Taheri

Ectopic pregnancy (EP) is reported in about 1%–2% of pregnant females and is associated with mortality and morbidity. Several genetic and environmental factors might modulate occurrence of EP. Prediction...

Long noncoding RNAs and their link to cancer

June 2020
Justine M. Grixti | Duncan Ayers

The central dogma of molecular biology, developed from the study of simple organisms such as Escherichia coli, has up until recently been that RNA functions mainly as an information intermediate between...

Differential expression analysis comparing EBV uninfected to infected human cell lines identifies induced non-micro small non-coding RNAs

March 2020
Lumbini I. Moss | Van S. Tompkins | Walter N. Moss

Epstein–Barr virus (EBV) is a ubiquitous human herpes virus, which is implicated in cancer and various autoimmune diseases. This study profiles non-micro small non-coding RNA expression changes induced...

Single nucleotide alterations in MicroRNAs and human cancer-A not fully explored field

March 2020
Dan Zhao

MicroRNAs are ~20 nt long small noncoding RNAs that are processed from stem-looped precursors and function mainly as posttranscriptional regulators of protein coding genes through binding to 3′-untranslated...

The 31-nucleotide Y4-RNA fragment in plasma is a potential novel biomarker

March 2020
Tatsuya Ishikawa | Arisa Haino | Mineaki Seki | Taro Kurihara | Takayuki Hirose | Yosuke Imai | Takuro Ishiguro | Takaaki Chou | Muneatsu Toshima | Hiroshi Terada | Masayuki Nashimoto

The 31- and 32-nt 5′-fragment of Y4-RNA (Y4RNAfr) exists abundantly in human peripheral blood plasma. Although physiological roles of the plasma Y4RNAfr are not well established, its potential utility...

Unravelling the role of long non-coding RNA - LINC01087 in breast cancer

March 2020
Rashmi Tripathi | Imlimaong Aier | Pavan Chakraborty | Pritish Kumar Varadwaj

Apoptosis is a ‘programmed fate’ of all cells participating in diverse physiological and pathological conditions. The role of critical regulators and their involvement in this complex multi-stage process...

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