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Recent Translational Medicine of Aging Articles

Recently published articles from Translational Medicine of Aging.

DDS promotes longevity through a microbiome-mediated starvation signal

Haeri Choi | Sung Chun Cho | Young Wan Ha | Billie Ocampo | Shirley Park | Shiwen Chen | Christopher F. Bennett | Jeehae Han | Ryan Rossner | Jong-Sun Kang | Yun-ll Lee | Sang Chul Park | Matt Kaeberlein

The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis...

The function of lncRNAs in aging-related diseases and 3D genome

Wanying Zhang | Tengfei Hu | Xiaoyuan Song

In the past decades, long noncoding RNAs (lncRNAs) have been indicated to play important roles in almost every biological process. Aging is a gradual and irreversible biological processes and associated...

An inexpensive microscopy system for microfluidic studies in budding yeast

Kenneth L. Chen | Toby N. Ven | Matthew M. Crane | Dexter E. Chen | Yen-Chi Feng | Nozomi Suzuki | Adam E. Russell | Diogo de Moraes | Matt Kaeberlein

Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high...

Applications of high-throughput ‘omics’ data in the study of frailty

Wen Lei | Yudai Xu | Jun Su | Cheong-Meng Chong | Huan-Xing Su | Junhong Luo | Evandro F. Fang | Zhijun Bao | Guobing Chen

Frailty is a common geriatric syndrome and a risk factor for many diseases, even mortality. However, the specific molecular biomarkers for diagnosis and therapeutic targets of frailty are still lacking....

NO-age in Norway

Evandro F. Fang | Hilde L. Nilsen | Jon Storm-Mathisen | Linda H. Bergersen

Senescence in aging and disorders of the central nervous system

Barbara L. Swenson | Charlton F. Meyer | Tyler J. Bussian | Darren J. Baker

Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...

Hypothesis: Plant stem cells hold the key to extreme longevity

Paul P. Dijkwel | Alvina G. Lai

Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not...

Role of the circadian clock in fine-tuning the process of leaf senescence in plants

Hyunmin Kim | Sunghyun Hong

Leaf senescence is a developmental process and a critical evolutionary strategy for fitness in plants, involving highly organized regulatory mechanisms. Many environmental signals as well as internal...

Nanocarriers targeting senescent cells

Daniel Muñoz-Espín

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological...

Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals

Hou-Ling Wang | Hongwei Guo | Zhonghai Li

Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention...

The functions of sarcopenia related myokines

January 2018
Lili Han | Si Wu | Ping Hu

Skeletal muscle is not only responsible for locomotion, but also a major metabolism and endocrine organ. Skeletal muscle produces several secreted factors to regulate the microenvironment of both muscle...

Therapeutic potential of boosting NAD+ in aging and age-related diseases

January 2018
Yahyah Aman | Yumin Qiu | Jun Tao | Evandro F. Fang

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging...

Translational geroscience: From invertebrate models to companion animal and human interventions

January 2018
Mitchell B. Lee | Matt Kaeberlein

Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan....

Meeting report: Asian Society for Aging Research Symposium 2018

January 2018
Yujin Lee | Seung-Jae V. Lee | Kyung-Jin Min

A toolkit for DNA assembly, genome engineering and multicolor imaging for C. elegans

January 2018
Bryan Sands | Nikolay Burnaevskiy | Soo R. Yun | Matthew M. Crane | Matt Kaeberlein | Alexander Mendenhall

One way scientists can observe and quantify processes in living cells is to engineer the genomes of animals to express multiple fluorescent proteins and then quantify those signals by various imaging...

The role of RNA helicases in aging and lifespan regulation

October 2017
Sangsoon Park | Hae-Eun H. Park | Heehwa G. Son | Seung-Jae V. Lee

RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes,...

Longevity control by the nervous system: Sensory perception, stress response and beyond

October 2017
Chih-Ta Lin | Chun-Wei He | Tzu-Ting Huang | Chun-Liang Pan

Life span is regulated by genetic mechanisms as well as environmental or physiological factors. Neurons detect sensory cues from the environment and internal signals generated within the animal, and...

Alternative splicing in aging and age-related diseases

October 2017
Huan Li | Ziyue Wang | Tianyi Ma | Gang Wei | Ting Ni

Alternative splicing (AS) of mRNA generates multiple protein isoforms from a single gene. This greatly expands proteome diversity and plays important roles in most biological processes. Global changes...

Meeting report: Fifth Asian Society for aging research symposium

October 2017
Takahiko Shimizu | Isao Shimokawa

Alcohol and aging: From epidemiology to mechanism

October 2017
Stuart S. Adamson | Lear E. Brace | Brian K. Kennedy

Alcohol is one of the most widely encountered drugs in the world and is credited with a wealth of health interactions. Light to moderate regular consumption (14–28 g daily) can promote heart health,...

Genome instability and aging: Cause or effect?

October 2017
Jan Vijg | Cristina Montagna

Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal...

Translational geroscience: A new paradigm for 21st century medicine

October 2017
Matt Kaeberlein

Advances in geroscience are allowing scientists and clinicians, for the first time, to consider interventions aimed at directly targeting the hallmarks of aging. Unlike disease-specific approaches,...

Serendipity in search for longevity from experiences of Hansen people

October 2017
Sang Chul Park

While surveying Korean centenarians, I had a fortune to encounter Hansen people, who spent long lives in the restricted sanatorium for leprosy patients. Their unexpectedly long life span compared with...

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