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Recent Translational Medicine of Aging Articles

Recently published articles from Translational Medicine of Aging.

The challenge of implementing frailty into clinical practice

Sathya Karunananthan | Nadia Sourial | Howard Bergman

RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

Matt Kaeberlein

The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...

Remodeling of the H3 nucleosomal landscape during mouse aging

Yilin Chen | Juan I. Bravo | Jyung Mean Son | Changhan Lee | Bérénice A. Benayoun

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and deregulation of gene expression correlates with aging. A key...

A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease

Emelyne Teo | Soon Yew John Lim | Sheng Fong | Anis Larbi | Graham D. Wright | Nicholas Tolwinski | Jan Gruber

Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...

Automation of C. elegans lifespan measurement

Daniel P. Felker | Christine E. Robbins | Mark A. McCormick

Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...

Computational tools for geroscience

Joseph C.P. Kruempel | Marshall B. Howington | Scott F. Leiser

The rapid progress of the past three decades has led the geroscience field near a point where human interventions in aging are plausible. Advances across scientific areas, such as high throughput “-omics”...

Advances in pharmacological interventions of aging in mice

Minxian Qian | Baohua Liu

The remarkable breakthroughs in aging research pave the way allowing us to explore potential interventions to slow down aging process, and more importantly, to improve healthiness. Multiple approaches,...

Nutrition, sarcopenia and frailty: An Asian perspective

Jean Woo | Sherlin Ong | Ruth Chan | Liz Li | Jianqin Sun | Yoke Mun Chan | Shiou-Liang Wee | Nghiem Nguyet Thu | Pham Thang | Siti Setiati | Yi-Chen Huang | Mark L. Wahlqvist | Lisette CPGM. de Groot

Despite a growing body of evidence that nutrition plays a key role in the pathophysiology, prevention and intervention programs of frailty and sarcopenia, as well as in promoting brain health, the awareness...

Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans

Eun Ji E. Kim | Seung-Jae V. Lee

Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs...

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast

Matthew M. Crane | Mitsuhiro Tsuchiya | Ben W. Blue | Jared D. Almazan | Kenneth L. Chen | Siobhan R. Duffy | Alexandra Golubeva | Annaiz M. Grimm | Alison M. Guard | Shauna A. Hill | Ellen Huynh | Ryan M. Kelly | Michael Kiflezghi | Hyunsung D. Kim | Mitchell Lee | Ting-I. Lee | Jiayi Li | Bao M.G. Nguyen | Riley M. Whalen | Feng Y. Yeh | Mark McCormick | Brian K. Kennedy | Joe R. Delaney | Matt Kaeberlein

An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and...

Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism

Gulperi Yalcin | Cheol-Koo Lee

Extension of lifespan and amelioration of aging-associated phenotypes have been targets of many studies. Some of the established methods of increasing lifespan including dietary restriction and genetic...

Steroid signaling mediates longevity responses to the eat-2 genetic model of dietary restriction in Caenorhabditis elegans

Mindy Farris | Lily Fang | Arianne Aslamy | Victor Pineda

Dietary restriction (DR) extends lifespan in a wide range of model organisms, including Caenorhabditis elegans. It is an interesting but yet to be addressed question whether hormones serve as a systemic...

Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

Shin-Hae Lee | Kyung-Jin Min

Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable...

Amino acids in the regulation of aging and aging-related diseases

Clare-Ann Canfield | Patrick C. Bradshaw

Amino acids are the building blocks of protein, but also play important cellular signaling roles. The mechanisms through which altered levels of many amino acids are sensed and the signals transmitted...

DDS promotes longevity through a microbiome-mediated starvation signal

Haeri Choi | Sung Chun Cho | Young Wan Ha | Billie Ocampo | Shirley Park | Shiwen Chen | Christopher F. Bennett | Jeehae Han | Ryan Rossner | Jong-Sun Kang | Yun-ll Lee | Sang Chul Park | Matt Kaeberlein

The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis...

The function of lncRNAs in aging-related diseases and 3D genome

Wanying Zhang | Tengfei Hu | Xiaoyuan Song

In the past decades, long noncoding RNAs (lncRNAs) have been indicated to play important roles in almost every biological process. Aging is a gradual and irreversible biological processes and associated...

An inexpensive microscopy system for microfluidic studies in budding yeast

Kenneth L. Chen | Toby N. Ven | Matthew M. Crane | Dexter E. Chen | Yen-Chi Feng | Nozomi Suzuki | Adam E. Russell | Diogo de Moraes | Matt Kaeberlein

Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high...

Applications of high-throughput ‘omics’ data in the study of frailty

Wen Lei | Yudai Xu | Jun Su | Cheong-Meng Chong | Huan-Xing Su | Junhong Luo | Evandro F. Fang | Zhijun Bao | Guobing Chen

Frailty is a common geriatric syndrome and a risk factor for many diseases, even mortality. However, the specific molecular biomarkers for diagnosis and therapeutic targets of frailty are still lacking....

NO-age in Norway

Evandro F. Fang | Hilde L. Nilsen | Jon Storm-Mathisen | Linda H. Bergersen

Senescence in aging and disorders of the central nervous system

Barbara L. Swenson | Charlton F. Meyer | Tyler J. Bussian | Darren J. Baker

Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...

Hypothesis: Plant stem cells hold the key to extreme longevity

Paul P. Dijkwel | Alvina G. Lai

Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not...

Role of the circadian clock in fine-tuning the process of leaf senescence in plants

Hyunmin Kim | Sunghyun Hong

Leaf senescence is a developmental process and a critical evolutionary strategy for fitness in plants, involving highly organized regulatory mechanisms. Many environmental signals as well as internal...

Nanocarriers targeting senescent cells

Daniel Muñoz-Espín

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological...

Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals

Hou-Ling Wang | Hongwei Guo | Zhonghai Li

Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention...

Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

Available online 12 September 2019
Richard O'Laughlin | Meng Jin | Yang Li | Lorraine Pillus | Lev S. Tsimring | Jeff Hasty | Nan Hao

Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative...

The functions of sarcopenia related myokines

January 2018
Lili Han | Si Wu | Ping Hu

Skeletal muscle is not only responsible for locomotion, but also a major metabolism and endocrine organ. Skeletal muscle produces several secreted factors to regulate the microenvironment of both muscle...

Therapeutic potential of boosting NAD+ in aging and age-related diseases

January 2018
Yahyah Aman | Yumin Qiu | Jun Tao | Evandro F. Fang

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging...

Translational geroscience: From invertebrate models to companion animal and human interventions

January 2018
Mitchell B. Lee | Matt Kaeberlein

Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan....

Meeting report: Asian Society for Aging Research Symposium 2018

January 2018
Yujin Lee | Seung-Jae V. Lee | Kyung-Jin Min

A toolkit for DNA assembly, genome engineering and multicolor imaging for C. elegans

January 2018
Bryan Sands | Nikolay Burnaevskiy | Soo R. Yun | Matthew M. Crane | Matt Kaeberlein | Alexander Mendenhall

One way scientists can observe and quantify processes in living cells is to engineer the genomes of animals to express multiple fluorescent proteins and then quantify those signals by various imaging...

The role of RNA helicases in aging and lifespan regulation

October 2017
Sangsoon Park | Hae-Eun H. Park | Heehwa G. Son | Seung-Jae V. Lee

RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes,...

Longevity control by the nervous system: Sensory perception, stress response and beyond

October 2017
Chih-Ta Lin | Chun-Wei He | Tzu-Ting Huang | Chun-Liang Pan

Life span is regulated by genetic mechanisms as well as environmental or physiological factors. Neurons detect sensory cues from the environment and internal signals generated within the animal, and...

Alternative splicing in aging and age-related diseases

October 2017
Huan Li | Ziyue Wang | Tianyi Ma | Gang Wei | Ting Ni

Alternative splicing (AS) of mRNA generates multiple protein isoforms from a single gene. This greatly expands proteome diversity and plays important roles in most biological processes. Global changes...

Meeting report: Fifth Asian Society for aging research symposium

October 2017
Takahiko Shimizu | Isao Shimokawa

Alcohol and aging: From epidemiology to mechanism

October 2017
Stuart S. Adamson | Lear E. Brace | Brian K. Kennedy

Alcohol is one of the most widely encountered drugs in the world and is credited with a wealth of health interactions. Light to moderate regular consumption (14–28 g daily) can promote heart health,...

Genome instability and aging: Cause or effect?

October 2017
Jan Vijg | Cristina Montagna

Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal...

Translational geroscience: A new paradigm for 21st century medicine

October 2017
Matt Kaeberlein

Advances in geroscience are allowing scientists and clinicians, for the first time, to consider interventions aimed at directly targeting the hallmarks of aging. Unlike disease-specific approaches,...

Serendipity in search for longevity from experiences of Hansen people

October 2017
Sang Chul Park

While surveying Korean centenarians, I had a fortune to encounter Hansen people, who spent long lives in the restricted sanatorium for leprosy patients. Their unexpectedly long life span compared with...

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