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Recent Translational Medicine of Aging Articles

Recently published articles from Translational Medicine of Aging.

Automation of C. elegans lifespan measurement

2020
Daniel P. Felker | Christine E. Robbins | Mark A. McCormick

Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...

A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease

2020
Emelyne Teo | Soon Yew John Lim | Sheng Fong | Anis Larbi | Graham D. Wright | Nicholas Tolwinski | Jan Gruber

Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...

Remodeling of the H3 nucleosomal landscape during mouse aging

2020
Yilin Chen | Juan I. Bravo | Jyung Mean Son | Changhan Lee | Bérénice A. Benayoun

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and deregulation of gene expression correlates with aging. A key...

RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

2020
Matt Kaeberlein

The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...

The challenge of implementing frailty into clinical practice

2020
Sathya Karunananthan | Nadia Sourial | Howard Bergman

Automated phenotyping and lifespan assessment of a C. elegans model of Parkinson’s disease

2020
Minwook Kim | Daniela Knoefler | Ellen Quarles | Ursula Jakob | Daphne Bazopoulou

Phenotypic analysis of Caenorhabditis elegans has greatly advanced our understanding of the molecular mechanisms implicated in the aging process as well as in age-related pathologies. However, conventional...

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

2020
Takashi K. Ito | Tomohito Sato | Akio Hakamata | Yuki Onoda | Shumpei Sato | Fumiyoshi Yamazaki | Makoto Horikawa | Yutaka Takahashi | Takuya Kitamoto | Masako Suzuki | Shinya Uchida | Keiichi Odagiri | Mitsutoshi Setou

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...

Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases

2020
Kate M. Van Pelt | Matthias C. Truttmann

Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...

Maintaining a scientific community while social distancing

2020
Dudley W. Lamming | Christy S. Carter

The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused...

Improving trainee engagement in science: Lessons from a virtual seminar series

2020
Hannah J. Smith

To be a successful researcher, you are expected to have important skills beyond the bench such as being able to ask questions, talk about science with your peers, and organize scientific events. However,...

Remote but not isolated

2020
William B. Mair

I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future....

ELOVL2: Not just a biomarker of aging

2020
Daniel L. Chao | Dorota Skowronska-Krawczyk

DNA methylation of the ELOVL2 (Elongation Of Very Long Chain Fatty Acids-Like 2) promoter is one of the most robust molecular biomarkers for chronological age, but whether ELOVL2 plays a functional...

Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function

2020
Maria Borja-Gonzalez | Jose C. Casas-Martinez | Brian McDonagh | Katarzyna Goljanek-Whysall

The microbiome: An emerging key player in aging and longevity

2020
Minhoo Kim | Bérénice A. Benayoun

Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host...

The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress

2020
Francesco A. Servello | Javier Apfeld

Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Here, we show that the heat...

Extracellular vesicles and extracellular RNA in aging and age-related disease

2020
Nicole Noren Hooten

Circulating factors are well known to influence aging and age-related disease. As part of the Aging Science Talks: Science for the Community series, data was presented on two types of circulating functional...

Role of hematopoietic aging in cognitive decline

2020
Helen S. Goodridge

We recently demonstrated that transplantation of young bone marrow cells rescued hippocampal learning and memory in old recipient mice. Our study also implicated CCL11/eotaxin-1 in microglial reactivity...

Integration of immune-metabolic signals to preserve healthy aging

2020
Emily L. Goldberg

Inflammation is a broad term that refers to a collection of carefully balanced programs in the body. These pathways are essential for detecting invading microorganisms, controlling the spread of infection,...

Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease

2020
Danielle E. Mor | Coleen T. Murphy

Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson’s disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies...

The eroding chromatin landscape of aging stem cells

2020
Changyou Shi | Lin Wang | Payel Sen

Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging,...

Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system

2020
Ana R. Silverstein | Melanie K. Flores | Brendan Miller | Su-Jeong Kim | Kelvin Yen | Hemal H. Mehta | Pinchas Cohen

Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry in the field of aging. Here, we outline the application of these techniques in the context...

SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast

2020
Eric M. Small | Daniel P. Felker | Olivia C. Heath | Ryla J. Cantergiani | Christine E. Robbins | Mary Ann Osley | Mark A. McCormick

Plate-reader based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast Saccharomyces...

Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals

2019
Hou-Ling Wang | Hongwei Guo | Zhonghai Li

Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention...

Role of the circadian clock in fine-tuning the process of leaf senescence in plants

2019
Hyunmin Kim | Sunghyun Hong

Leaf senescence is a developmental process and a critical evolutionary strategy for fitness in plants, involving highly organized regulatory mechanisms. Many environmental signals as well as internal...

Nanocarriers targeting senescent cells

2019
Daniel Muñoz-Espín

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological...

Hypothesis: Plant stem cells hold the key to extreme longevity

2019
Paul P. Dijkwel | Alvina G. Lai

Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not...

Senescence in aging and disorders of the central nervous system

2019
Barbara L. Swenson | Charlton F. Meyer | Tyler J. Bussian | Darren J. Baker

Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...

NO-age in Norway

2019
Evandro F. Fang | Hilde L. Nilsen | Jon Storm-Mathisen | Linda H. Bergersen

Applications of high-throughput ‘omics’ data in the study of frailty

2019
Wen Lei | Yudai Xu | Jun Su | Cheong-Meng Chong | Huan-Xing Su | Junhong Luo | Evandro F. Fang | Zhijun Bao | Guobing Chen

Frailty is a common geriatric syndrome and a risk factor for many diseases, even mortality. However, the specific molecular biomarkers for diagnosis and therapeutic targets of frailty are still lacking....

An inexpensive microscopy system for microfluidic studies in budding yeast

2019
Kenneth L. Chen | Toby N. Ven | Matthew M. Crane | Dexter E. Chen | Yen-Chi Feng | Nozomi Suzuki | Adam E. Russell | Diogo de Moraes | Matt Kaeberlein

Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high...

The function of lncRNAs in aging-related diseases and 3D genome

2019
Wanying Zhang | Tengfei Hu | Xiaoyuan Song

In the past decades, long noncoding RNAs (lncRNAs) have been indicated to play important roles in almost every biological process. Aging is a gradual and irreversible biological processes and associated...

DDS promotes longevity through a microbiome-mediated starvation signal

2019
Haeri Choi | Sung Chun Cho | Young Wan Ha | Billie Ocampo | Shirley Park | Shiwen Chen | Christopher F. Bennett | Jeehae Han | Ryan Rossner | Jong-Sun Kang | Yun-ll Lee | Sang Chul Park | Matt Kaeberlein

The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis...

Amino acids in the regulation of aging and aging-related diseases

2019
Clare-Ann Canfield | Patrick C. Bradshaw

Amino acids are the building blocks of protein, but also play important cellular signaling roles. The mechanisms through which altered levels of many amino acids are sensed and the signals transmitted...

Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

2019
Shin-Hae Lee | Kyung-Jin Min

Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable...

Steroid signaling mediates longevity responses to the eat-2 genetic model of dietary restriction in Caenorhabditis elegans

2019
Mindy Farris | Lily Fang | Arianne Aslamy | Victor Pineda

Dietary restriction (DR) extends lifespan in a wide range of model organisms, including Caenorhabditis elegans. It is an interesting but yet to be addressed question whether hormones serve as a systemic...

Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism

2019
Gulperi Yalcin | Cheol-Koo Lee

Extension of lifespan and amelioration of aging-associated phenotypes have been targets of many studies. Some of the established methods of increasing lifespan including dietary restriction and genetic...

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast

2019
Matthew M. Crane | Mitsuhiro Tsuchiya | Ben W. Blue | Jared D. Almazan | Kenneth L. Chen | Siobhan R. Duffy | Alexandra Golubeva | Annaiz M. Grimm | Alison M. Guard | Shauna A. Hill | Ellen Huynh | Ryan M. Kelly | Michael Kiflezghi | Hyunsung D. Kim | Mitchell Lee | Ting-I. Lee | Jiayi Li | Bao M.G. Nguyen | Riley M. Whalen | Feng Y. Yeh | Mark McCormick | Brian K. Kennedy | Joe R. Delaney | Matt Kaeberlein

An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and...

Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans

2019
Eun Ji E. Kim | Seung-Jae V. Lee

Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs...

Nutrition, sarcopenia and frailty: An Asian perspective

2019
Jean Woo | Sherlin Ong | Ruth Chan | Liz Li | Jianqin Sun | Yoke Mun Chan | Shiou-Liang Wee | Nghiem Nguyet Thu | Pham Thang | Siti Setiati | Yi-Chen Huang | Mark L. Wahlqvist | Lisette CPGM. de Groot

Despite a growing body of evidence that nutrition plays a key role in the pathophysiology, prevention and intervention programs of frailty and sarcopenia, as well as in promoting brain health, the awareness...

Advances in pharmacological interventions of aging in mice

2019
Minxian Qian | Baohua Liu

The remarkable breakthroughs in aging research pave the way allowing us to explore potential interventions to slow down aging process, and more importantly, to improve healthiness. Multiple approaches,...

Computational tools for geroscience

2019
Joseph C.P. Kruempel | Marshall B. Howington | Scott F. Leiser

The rapid progress of the past three decades has led the geroscience field near a point where human interventions in aging are plausible. Advances across scientific areas, such as high throughput “-omics”...

Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

Available online 12 September 2019
Richard O'Laughlin | Meng Jin | Yang Li | Lorraine Pillus | Lev S. Tsimring | Jeff Hasty | Nan Hao

Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative...

A toolkit for DNA assembly, genome engineering and multicolor imaging for C. elegans

January 2018
Bryan Sands | Nikolay Burnaevskiy | Soo R. Yun | Matthew M. Crane | Matt Kaeberlein | Alexander Mendenhall

One way scientists can observe and quantify processes in living cells is to engineer the genomes of animals to express multiple fluorescent proteins and then quantify those signals by various imaging...

Translational geroscience: From invertebrate models to companion animal and human interventions

January 2018
Mitchell B. Lee | Matt Kaeberlein

Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan....

The functions of sarcopenia related myokines

January 2018
Lili Han | Si Wu | Ping Hu

Skeletal muscle is not only responsible for locomotion, but also a major metabolism and endocrine organ. Skeletal muscle produces several secreted factors to regulate the microenvironment of both muscle...

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