A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects
2021
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide,...
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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice
2021
Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies...
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Heart failure risk remote monitoring program in the very elderly patients with COVID-19 disease
2021
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The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
2021
We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins....
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A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects
2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...
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Maintaining a scientific community while social distancing
2020
The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused...
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Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases
2020
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...
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Automation of C. elegans lifespan measurement
2020
Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...
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RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
2020
The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...
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Extracellular vesicles and extracellular RNA in aging and age-related disease
2020
Circulating factors are well known to influence aging and age-related disease. As part of the Aging Science Talks: Science for the Community series, data was presented on two types of circulating functional...
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Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system
2020
Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry in the field of aging. Here, we outline the application of these techniques in the context...
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Role of hematopoietic aging in cognitive decline
2020
We recently demonstrated that transplantation of young bone marrow cells rescued hippocampal learning and memory in old recipient mice. Our study also implicated CCL11/eotaxin-1 in microglial reactivity...
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SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast
2020
Plate-reader based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast Saccharomyces...
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A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease
2020
Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...
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Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease
2020
Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson’s disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies...
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The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress
2020
Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Here, we show that the heat...
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Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae
2020
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative...
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Remote but not isolated
2020
I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future....
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Integration of immune-metabolic signals to preserve healthy aging
2020
Inflammation is a broad term that refers to a collection of carefully balanced programs in the body. These pathways are essential for detecting invading microorganisms, controlling the spread of infection,...
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