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Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice
July 2024
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Resident to exhausted CD4+ T cell ratio is associated with the prognosis of gastric cancer
July 2024
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Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases
July 2024
The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities. The hepatobiliary system originates from the foregut endoderm, in which cells undergo...
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Advances in the application of hydrogel-based scaffolds for tendon repair
July 2024
Tendon injuries often lead to joint dysfunction due to the limited self-regeneration capacity of tendons. Repairing tendons is a major challenge for surgeons and imposes a significant financial burden...
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PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma
July 2024
Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program. Phosphoenolpyruvate carboxylase 1 (PCK1), a gluconeogenic metabolic enzyme, is down-regulated in hepatocellular...
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Insights into the role of RNA m6A modification in the metabolic process and related diseases
July 2024
According to the latest consensus, many traditional diseases are considered metabolic diseases, such as cancer, type 2 diabetes, obesity, and cardiovascular disease. Currently, metabolic diseases are...
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PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α
July 2024
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle...
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CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer
July 2024
CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5 directly influences cancer progression. In this...
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Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4
July 2024
Gastric cancer is highly prevalent among digestive tract tumors. Due to the intricate nature of the gastric cancer immune microenvironment, there is currently no effective treatment available for advanced...
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Twenty years of Gendicine® rAd-p53 cancer gene therapy: The first-in-class human cancer gene therapy in the era of personalized oncology
July 2024
Genetic mutations in TP53 contribute to human malignancies through various means. To date, there have been a variety of therapeutic strategies targeting p53, including gene therapy to restore normal...
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A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort
July 2024
Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome (SSNS) using genome-wide association studies (GWAS) strategy is important for...
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