Near infrared spectroscopy discrimination and pattern recognition of Chinese Pogostemon cablin and Agastache rugosa
October 2023
Pogostemon cablin (Blanco) Benth. and Agastache rugosa (Fisch. et Mey.) O. Ktze. are commonly used traditional Chinese medicines. They belong to the family Lamiaceae and have very similar macroscopical...
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A new design of coculture microfluidic chip for HepG2 and LO2 cells
October 2023
In order to better screen targeted drugs, a microfluidic chip that can culture both diseased and normal cells is designed....
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Analysis of clinical drug use and construction of pharmacy service model for children with Kawasaki disease based on integration concept
October 2023
This study aimed to summarize and share the experience of clinical pharmacists in the clinical treatment of children with Kawasaki disease based on the “integration” concept....
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Tianhuang formula ameliorates non-alcoholic fatty liver diseases in type 2 diabetic mice through CRLS1-ATF3/ChREBP pathway
October 2023
Tianhuang Formula (THF) is a hospital formula summarized by Professor Jiao Guo's 30 years of clinical experience. Some studies have shown that it can alleviate dyslipidemia in the body. The purpose...
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Dioscoreae persimilis polysaccharide ameliorates DSS-induced ulcerative colitis in mice through modulation of microbiota composition
October 2023
Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that has a high rate of recurrence, development of novel therapeutic approaches with high efficacy and few adverse effects are still...
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Forsythiae Fructus attenuates cisplatin-induced cytotoxicity in IEC-6 cells and J774A.1 macrophages by inhibiting NLRP3/caspase-1/GSDMD mediated pyroptosis
October 2023
Forsythiae Fructus (lian qiao in Chinese), the dried fruit of Forsythia suspensa (Thunb.) Vahl, is a commonly used traditional Chinese medicine known for its diverse biological activities, including...
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Xiaochaihu decoction induces Bel-7402/5-FU cell apoptosis and autophagy via PI3K/AKT/mTOR pathway
October 2023
This study aimed to observe the inhibitory effects of xiaochaihu decoction (XCHD) on human hepatocellular carcinoma (HCC) cells resistant to 5-fluorouracil (5-FU) (Bel-7402/5-FU) in vitro and in vivo...
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Effects of Alpinia Officinarum and Euodia Rutaecarpa on the expression of TRPA1 and TRPM8 in rats with irritable bowel syndrome
March 2023
Alpinia Officinarum and Euodia Rutaecarpap are two traditional Chinese herbs with warm nature, usually called interior-warming medicinal and widely used to treat cold syndrome for a long history. The...
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Pan-cancer analysis reveals the relationship between SLC47A1 immune infiltration and clinical prognosis of human tumors
March 2023
Objective To analyze the differential expression and prognosis of Solute Carrier Family 47 Member 1 (SLC47A1) in human pan-cancer using bioinformatic methods to explore the prognostic value of SLC47A1...
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Pan-cancer analysis highlights the role of PSENEN in the prognosis and immunology of cancer
March 2023
Presenilin enhancer-2 (PSENEN, PEN-2), one of the four components of the γ-secretase complex, has been increasingly revealed to be significant in cancer types such as pancreatic cancer, gastric cancer,...
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Clinical analysis of the efficacy of thalidomide combined with finger pointing in the treatment of ankylosing spondylitis
March 2023
This study aims to investigate the different treatment protocols for ankylosing spondylitis (AS) in the clinic. In this paper, finger point therapy and thalidomide were proposed to be used in the treatment...
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Impact of seasonal variations on polyphenolic content and antibacterial activity in Berberis lycium Royl
March 2023
Periodic changes in the environmental conditions affect significantly on the biosynthesis of bioactive compounds and the therapeutic potential in medicinal plants. Although Berberis lycium is being...
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Meta-analysis of the impact of pharmaceutical care on the outcome of gestational diabetes
March 2023
Pharmaceutical care is based on pharmacy, effective organization, and the management of drugs and patients throughout the medication process, to promote the scientific and rational use of drugs. This...
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Tissue-specific comparative transcriptome analysis reveals candidate genes involved in lignans biosynthesis in Saururus chinensis
March 2023
To investigate the functional genes involved in the lignans biosynthesis in Saururus chinensis....
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The volatile oil from Acori Graminei Rhizoma downregulates NMDARs-ERK1/2-CREB signaling pathway to alleviate pain related emotions induced by inflammatory pain in rats
March 2023
To investigate whether Acori Graminei Rhizoma (AGR) volatile oil can reduce inflammatory pain-induced pain-related mood in rats by downregulating NMDARs-ERK 1/2-CREB signaling pathway....
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Ursolic acid induces apoptosis and autophagy of HCT-8/5-FU cells
December 2022
To observe the effects of ursolic acid (UA) on the apoptosis, autophagy and mTOR of human colorectal cancer (CRC) cells resistant to 5-FU (HCT-8/5-FU), and explore the mechanisms of UA reversing the...
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Infarction or reperfusion-induced cardiac autophagy: role of microRNAs
December 2022
The process of cardiomyocyte death is triggered by prolonged ischemia in the heart during myocardial infarction (MI). And the role of non-coding RNAs in the pathophysiology of cardiovascular diseases...
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Analysis on the treatment of acne by Sanhuang with network pharmacology and experimental research
December 2022
To explore the main active components and potential targets of “Sanhuang Xiexin decoction” (Sanhuang) against acne based on network pharmacology and molecular docking technology, and research the bacteriostatic...
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Molecular mechanisms of RNA m6A-modifying enzymes in cardiovascular diseases
December 2022
Cardiovascular diseases are the leading causes of death globally. Their pathological mechanisms are complex and have not yet been fully clarified. With the development of epigenetics research in recent...
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Motor learning dysfunction and its association with neurotransmitters and gut microbiota dysbiosis in hepatic encephalopathy mice
December 2022
This study aims to investigate the potential mechanisms underlying motor learning dysfunction in hepatic encephalopathy (HE) mice using gut microbiota and neurochemicals....
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Effect and mechanism of Buyang Huanwu decoction on retinal inflammation in streptozotocin-induced diabetic rats
December 2022
To observe the protective effect of Buyang Huanwu decoction (BYHWD) against retinal inflammation in diabetic rats....
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Molecular mechanism and rule of TCM prescriptions containing Alismatis Rhizoma in the clinical treatment of hyperlipidemia based on data mining and network pharmacology
December 2022
The clinical treatment rules and mechanism of Alismatis Rhizoma prescription for hyperlipidemia treatment were analyzed based on data mining and network pharmacology....
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Antiseptic property screening for 18 natural plants and efficiency–toxicity research of Coptis chinensis fermentation
December 2022
This study aimed to compare the antibacterial performance of 18 natural plants against six types of microorganisms that tend to grow in cosmetics and select the best natural antiseptic herbs with low...
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Oxidative low-density lipoprotein oxLDL induces pyroptosis in trophoblast cells HTR-8/Svneo by downregulating TET2
December 2022
To investigate pyroptosis in the trophoblast cells HTR-8/Svneo induced by TET2 in oxidized low-density lipoprotein (oxLDL)....
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