Nitrate and body homeostasis
March 2024
Homeostasis is essential for the maintenance of health, and how it is maintained is the focus of attention in homeostatic medicine. As a natural dietary nutrient, nitrate is critical in regulating homeostasis....
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder
March 2024
Early-onset schizophrenia (EOS) and autism spectrum disorder (ASD) are two mental disorders with abnormal neurodevelopment and overlapping clinical symptoms. However, few prospective multi-center imaging...
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Artificial intelligence in coronary computed tomography angiography
March 2024
The rapid development of artificial intelligence (AI) technologies, like machine learning, deep learning, and other algorithms applied to the intelligent diagnostic and decision making, image interpretation,...
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Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
March 2024
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate...
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Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery
March 2024
Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology,...
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Tumor deposits in colorectal and gastric cancers
June 2024
Tumor deposits (TDs), initially recognized in colorectal cancer (CRC), have been identified in various other cancer types, including gastric cancer (GC), rendering them a widely studied adverse prognostic...
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Delayed treatment effect predicting (DTEP) model for guiding immuno-oncology trial designs
March 2024
The presence of delayed treatment effects (DTE) is common in immuno-oncology trials. However, conventional trial designs often overlook the potential presence of DTE, which can result in an underestimation...
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A molecular glue for P53
Available online 26 April 2024
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