Highly tough and conformal silk-based adhesive patches for sutureless repair of gastrointestinal and peripheral nerve defects
November 2025
The use of tissue adhesive patches provides a promising therapeutic approach for sutureless repair of soft tissue injuries. However, existing tissue adhesive patches are confronted with serious challenges...
Share article
Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy
November 2025
The post-radiotherapy wounds are common in patients. The irradiation-induced reactive oxygen species (ROS) accumulation, nucleic acid damage, and inflammation greatly hinder wound healing. The irradiation-induced...
Share article
Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis
November 2025
The treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels...
Share article
Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation
October 2025
Repositioning and securing the cranial bone flap after craniotomy remain significant challenges in neurosurgery. Traditional fixation methods often suffer from weak mechanical strength, bioinertness,...
Share article
Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects
October 2025
Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate...
Share article
Engineering microneedles for biosensing and drug delivery
October 2025
Microneedles (MNs) are small, minimally invasive devices that typically measure from tens to hundreds of micrometers in length and are usually less than a millimeter in diameter. Their purpose is to...
Share article
Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy
October 2025
Traditional antitumor strategies often require sufficient time to assess the effectiveness according to changes in tumor structure. Once ineffective, patients may miss the critical window for pursuing...
Share article
Antiviral nanomedicine: Advantages, mechanisms and advanced therapies
October 2025
The emergence of novel viral pathogens and the limitations of conventional antiviral therapies necessitate innovative strategies to combat persistent and pandemic threats. This review details the role...
Share article
A dual-targeting strategy to inhibit colorectal cancer liver metastasis via tumor cell ferroptosis and cancer-associated fibroblast reprogramming
October 2025
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, with liver metastasis posing a significant therapeutic challenge. Within the “seed and soil” paradigm, disrupting both tumor...
Share article
Charge balance transition enabled Janus hydrogel for robust wet-tissue adhesion and anti-postoperative adhesion
October 2025
Janus hydrogels have recently emerged as promising bioadhesives for efficient wet-tissue adhesion and anti-postoperative adhesion. However, existing Janus hydrogel adhesives normally need varied chemical...
Share article
Trapzyme as multimodal Janus nanoplatform for apoptosis-based immunotherapy of periodontitis
October 2025
Accumulation of pro-inflammatory macrophages caused by apoptosis deficiency is a major contributing factor for periodontitis progression. Inducing apoptosis of these macrophages is thus a promising...
Share article
Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity
October 2025
Chronic nephritis management remains challenging due to the compromised therapeutic efficacy and severe systemic complications of conventional glucocorticoid therapy. Here, we developed a bioinspired...
Share article
Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing
October 2025
Wound healing remains a critical clinical challenge due to inflammatory responses, oxidative stress in the wound microenvironment, and impaired tissue remodeling. In this study, an anisotropic scaffold...
Share article
Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration
October 2025
This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering...
Share article
Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform
October 2025
Extracellular vesicles (EVs) have emerged as a promising pharmacotherapeutic modality for glioblastoma (GBM) drug delivery. However, the clinical translation of EVs remains restricted due to their low...
Share article
Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery
October 2025
Coacervate microdroplets, formed via liquid-liquid phase separation, represent a transformative platform in biomacromolecule delivery due to their unique physicochemical properties, such as ultralow...
Share article
One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration
October 2025
The repair of bone defects relies on the intricate coordination of inflammation, angiogenesis, and osteogenesis. However, scaffolds capable of integrating osteo-immunomodulation and vascular-bone coupling...
Share article
Near-infrared light-induced photothermal and immunotherapy system for lung cancer bone metastasis treatment with simultaneous bone repair
October 2025
Approximately half of lung cancer patients experience bone metastasis, leading to bone loss, fracture, and other skeletal-related events. Although immunotherapies have significantly advanced the therapeutic...
Share article
AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4
October 2025
Burn wound healing is a multifaceted process often complicated by excessive inflammation and impaired keratinocyte function, both of which are key factors contributing to delayed healing. In this study...
Share article
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system
October 2025
The success of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) is greatly limited by the scarcity of cytotoxic T lymphocytes (CTLs) in tumor microenvironment, which is mainly due to the physical...
Share article
Synergistic mastery: Advancing mechanical and electrical harmony in conducting polymer hydrogel bioelectronics
October 2025
Conducting polymer hydrogels offer promising electrical interfaces with biological tissues for electrophysiological signal recording, sensing, and stimulation due to their favorable electrical properties,...
Share article
Research trends of piezoelectric materials in neurodegenerative disease applications
October 2025
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and huntington's disease, pose significant threats to human health, with...
Share article
Emerging technologies towards extracellular vesicles large-scale production
October 2025
Extracellular vesicles (EVs), which carry bioactive components such as proteins and nucleic acids, reflect the physiological state of their parent cells and play a key role in mediating complex intercellular...
Share article
Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects
October 2025
Smart-responsive materials, which possess the capacity to receive signals from the environment and engage in dynamic communication with it, have significantly expanded the frontiers of tissue engineering...
Share article
Multifunctional DNA hydrogels with light-triggered gas-therapy and controlled G-Exos release for infected wound healing
October 2025
Infectious wound healing remains a significant medical challenge due to chronic inflammation and bacterial colonization. Effective antimicrobial and anti-inflammatory therapies are essential to facilitate...
Share article
Production and hosting by Elsevier on behalf of KeAi Communications Co. Ltd