Fine-tuning the cell morphology of Corynebacterium glutamicum via dual-valve regulation for enhanced hyaluronic acid production
2023
Enhanced synthesis of hyaluronic acid (HA) with recombinant Corynebacterium glutamicum as production host was achieved in this work. Hyaluronan synthase (HAS), which is a membrane protein acting as...
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Dual-plasmid interactions stimulate the accumulation of valencene in Saccharomyces cerevisiae
2023
Plasmids are one of the most commonly used basic tools in the construction of microbial cell factories, the use of which individually or in pairs play an important role in the expression of exogenous...
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Resveratrol production of a recombinant Scheffersomyces stipitis strain from molasses
2022
Resveratrol is a plant-derived aromatic compound with beneficial properties and it is required to develop a resveratrol production process from inexpensive biomass feedstocks. Here, we investigated...
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Synthetic biology landscape and community in Germany
2022
Despite its start in the early 2000s, synthetic biology is still overall perceived as a young discipline. In some countries, such as the US, synthetic biology is academically and industrially established,...
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Model-based dynamic engineering of Escherichia coli for N-acetylglucosamine overproduction
2022
N-acetylglucosamine (GlcNAc), a glucosamine derivative, has a wide range of applications in pharmaceutical fields, and there is an increasing interest in the efficient production of GlcNAc genetic engineered...
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Coupled synthetic pathways improve the production of 3-hydroxypropionic acid in recombinant Escherichia coli strains
2022
To improve the production of 3-HP with glucose as a substrate, the malonyl-CoA and propionyl-CoA pathways were coupled to regulate NADP+/NADPH regeneration in the recombinant E. coli. The strain Ec-AM...
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Hyperuricemia and the small intestine: Transport mechanisms and co-morbidities
2022
There is a global increase in cases of hyperuricemia over the last 10 years. A critical component of serum uric acid control is the transport of uric acid to the intestinal lumen, which accounts for...
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Immunomodulatory effects of Abelmoschus esculentus water extract through MAPK and NF-κB signaling in RAW 264.7 cells
2022
During the current COVID-19 pandemic, the world is facing a new, highly contagious virus that suppresses innate immunity as one of its early virulence mechanisms. Therefore, finding new methods to enhance...
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De novo synthesis of synthetic biology ecosystem in Slovakia: Challenges and opportunities
2022
Synthetic biology is an engineering discipline that applies engineering principles to rationally design novel biological systems. It has the potential to contribute to solving major global challenges...
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Following the organism to map synthetic genomics
2022
Synthetic genomics, or engineering biology at the level of whole genomes and whole organisms, is an emerging outgrowth of parts-based synthetic biology. This nascent subfield is also diverse and difficult...
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A SynBio community comes of age: Political, academical, industrial, and societal developments in the Netherlands
2022
Synthetic biology (SynBio) is a rapidly growing scientific discipline. In the Netherlands, various universities and companies are tackling a variety of opportunities and challenges within this field....
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Synthetic biology landscape in the UK
2022
The UK is home to a vibrant and diverse synthetic biology community. Many of its successes in research innovation and technological commercialisation can be attributed to a strong base of dedicated...
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Synthetic biology in Europe: current community landscape and future perspectives
2022
Synthetic biology has captivated scientists' imagination. It promises answers to some of the grand challenges society is facing: worsening climate crisis, insufficient food supplies for ever growing...
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Micelle morphology observation method of lipopeptide by negative-staining-based transmission electron microscopy
2022
Lipopeptides, novel biosurfactants showing versatile promising applications in enhanced oil recovery, textile industry, agriculture and daily chemical products, etc., are profoundly highlighted recently....
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Integrated strategy of CRISPR-Cas9 gene editing and small RNA RhyB regulation in Enterobacter aerogenes: A novel protocol for improving biohydrogen production
2022
Dark fermentation is considered as one of the most practical biological hydrogen production methods. However, current productivity and yield are still not economically viable for industrial applications....
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Construction of an ultra-strong PtacM promoter via engineering the core-element spacer and 5′ untranslated region for versatile applications in Corynebacterium glutamicum
2022
As one of the most important synthetic biology elements in transcriptional regulation, promoters play irreplaceable roles in metabolic engineering. For the industrial microorganism Corynebacterium glutamicum,...
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Ribosome purification from Escherichia coli by ultracentrifugation
2022
With more and more researchers conducting extensive research on all aspects of ribosomes, how to extract ribosomes with good effect and high activity has become a fundamental problem. In this article,...
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Cell-free synthetic biology: Orchestrating the machinery for biomolecular engineering
2022
Due to inherent complexity, incompatibility, and variability in living cell systems, biomolecular engineering faces significant obstacles. To find novel solutions to these issues, researchers have turned...
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MvaT negatively regulates pyocin S5 expression in Pseudomonas aeruginosa
2022
Regulatory mechanisms that direct the synthesis and release of pyocin S5, a surface-acting bacteriocin produced by Pseudomonas aeruginosa, are relatively unknown. This study aims to identify transcription...
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Development of destabilized mCherry fluorescent proteins for applications in the model yeast Saccharomyces cerevisiae
2022
Fluorescent proteins are widely used molecular reporters in studying gene expression and subcellular protein localization. To enable the monitoring of transient cellular events in the model yeast Saccharomyces...
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2022 The 1st Western China symposium on the international frontier of synthetic biomanufacturing
2022
The 1st western China symposium on the international frontier of synthetic biomanufacturing was successfully held on July 8–10 in 2022. The conference is firstly launched by Professor Dan Wang in Chongqing...
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Building the SynBio community in the Czech Republic from the bottom up: You get what you give
2022
Given its highly innovative character and potential socioeconomic impact, Synthetic Biology is often ranked among prominent research areas and national research priorities in developed countries. The...
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The transport of triterpenoids
2021
Triterpenoids are a group of natural products with promising biological activities. Studying the transport of triterpenoids is of vital importance for designing novel microbial cell factory for efficient...
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Substrate promiscuity of the NdmCDE N7-demethylase enzyme complex
2021
Methylxanthines, including caffeine and theophylline, are a class of natural and synthetic compounds with important roles in food, cosmetics, and medicine. These compounds are metabolized by bacteria...
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