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Recent Digital Chinese Medicine Articles

Recently published articles from Digital Chinese Medicine.

Research on Text Mining of Syndrome Element Syndrome Differentiation by Natural Language Processing

June 2019
Deng Wen-Xiang | Zhu Jian-Ping | Li Jing | Yuan Zhi-Ying | Wu Hua-Ying | Yao Zhong- Hua | Zhang Yi-Ge | Zhang Wen-An | Huang Hui-Yong

Natural language processing (NLP) was used to excavate and visualize the core content of syndrome element syndrome differentiation (SESD)....

Network Pharmacology-based Analysis on the Molecular Biological Mechanisms of Xin Hui Tong Formula in Coronary Heart Disease Treatment

June 2019
Wu Hua-Ying | Zhang Chen | Wang Zhao-Hua | Zhang Shi-Ying | Li Jing | Li Feng | Huang Hui-Yong | Li Liang

To investigate the potential molecular mechanism of Xin Hui Tong Formula (XHTF) in the treatment of coronary heart disease (CHD) by using network pharmacology and bioinformatics....

Effects of Buddlejae Flos Granules on Inflammatory Factors TGF-β1, NF-κB, IL-10 and IL-12 in Lacrimal Gland Cells of Castrated Male Rabbits

June 2019
Jiang Peng-Fei | Peng Jun | Tan Han-Yu | Ou-Yang Yun | Qin Gen-Yan | Peng Qing-Hua

To observe the effects of Buddlejae Flos (Mi Meng Hua, 密蒙花) granules on the expression of TGF-β1, NF-κB, IL-10 and IL-12 in lacrimal gland cells in castrated male rabbits....

Methylation Characteristics of Perivisceral Fat Gene in Obese Rats with Phlegm-dampness Syndrome and the Effect of Wen Dan Decoction

June 2019
Yang Hai-Yan | Yu Song-Ren | Xia Xun-Li | Cheng Shao-Min | Wang Ping

To observe the characteristics of gene methylation in obese rats with phlegm-dampness syndrome induced by the high-fat diet, and to study the effect of Wen Dan Decoction on gene methylation after the...

Triterpenoid Saponins from Tu Jia Ethnomedicine Bai San Qi and Their Cytotoxicity on Hep G2 and BGC-823 Cell Lines

June 2019
Li Wei | Muhammad Daniyal | Xie Qing-Ling | Liu Yang | Xie Qian | Li Bin | Peng Cai-Yun | Wang Wei

Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey. (Bai San Qi, 白三七) is recognized as an effective and...

Effects of Zhuang Gu Zhi Tong Formula on Wnt/β-catenin Osteoporosis Pathway Antagonist SOST in Osteoporosis

June 2019
Liu Xiang-Lin | Liu Le-Ping | He Rong | Zhang Shu-Qi | Zhao Zi-Yi | Peng Ting | Liu Hui-Ping | Zhang Guo-Min

To observe the effects of Zhuang Gu Zhi Tong Formula (ZGZTF) on antagonist SOST in canonical Wnt/β-catenin signaling pathway in osteoporosis....

Thoughts About Paths for Digitization of Traditional Chinese Medicine - Refined Data Elements

March 2019
Zhou Xiao-Qing | Zhang Qi-Jie | Zheng Cai-Xing | Tong Tian-Hao | Yu Hao

For digitalization of traditional Chinese medicine (TCM), research is being conducted on objectivization of diagnosis and treatment, mathematical models of TCM theories, and application of modern information...

α-Glucosidase Inhibitory Activity-guided Identification of Compounds from Clerodendrum bungei Steud by HPLC-ESI- QTOF-MS/MS

March 2019
Huang Xiao-Long | Wan Dan | Shu Jun | Fang Liang-Zi | Zou Du-Zhun | Zhang Shui-Han

To identify the compounds with α-glucosidase inhibitory activity from Clerodendrum bungei Steud (Chou Mu Dan, 臭牡丹) using HPLC-ESI-QTOF-MS/MS....

Dan Huang Ming Mu Recipe Suppresses the Progression of Streptozotocin-induced Diabetic Retinopathy After Retinal Laser Photocoagulation in Brown Norway Rats via Down-regulating Vascular Endothelial Growth Factor and Up-regulating Pigment Epithelium-derived Factor

March 2019
Nie Fu-Jiao | Liu Zhi-Min | Sun Shu-Ming | Yang Yi-Jing | Chen Xiang-Dong | Peng Qing-Hua

To analyze the effects of Dan Huang Ming Mu Recipe (DHMMR) (a pharmaceutical preparation from herbs and having the function of replenishing vital essence, removing heat, promoting blood circulation...

Pretreatment with Lithospermic Acid Attenuates Oxidative Stress- induced Apoptosis in Bone Marrow-derived Mesenchymal Stem Cells via Anti-oxidation and Activation of PI3K/Akt Pathway

March 2019
Li Wang-Yang | Zhou You-Liang | Li Tiao | Zeng Peng | Xu Wu-Ji | Lu Xiao-Long | Qi Xin-Yu | Xiong Hui

Despite the potential therapeutic approaches of bone marrow-derived mesenchymal stem cells (BMSCs) in orthopaedic, their applications are hampered by harsh oxidative stress conditions after transplantation....

Systems Pharmacological Approach to Investigate the Mechanism of Hericium erinaceus for Alzheimer’s Disease

March 2019
Gunter P. Eckert | Song Zhen-Yan | Cheng Shao-Wu

To confirm evidence regarding the potential therapeutic effect of Hericium erinaceus (H. erinaceus, Hou Tou Gu, 猴头菇) on Alzheimer’s disease (AD) using a system pharmacological approach in silico....

Differentiating Trachemys scripta elegans Shell Glue from Chinemys reevesii Shell Glue by UPLC-QTOF/MS Coupled with Binary Compare Tool of UNIFI

March 2019
Tang Min | Yan Jian-Ye | Ren Jie | Li Shun-Xiang

This study was conducted to develop an method for identification of Trachemys scripta elegans (Ba Xi Gui, 巴西龟) shell glue from Chinemys reevesii (Zhong Hua Cao Gui, 中华草龟) shell glue....

Hub Genes of Astrocyte Involved in Glaucoma with Ocular Hypertension by Integrated Bioinformatics Analysis

December 2018
Yi-Jing YANG | Yu XIANG | Ye TIAN | Fei XIA | Ya-Sha ZHOU | Jun PENG | Qing-Hua PENG

Objective This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension....

Advance in Studies on Chemical Constituents, Pharmacology and Quality Control of Aquilaria sinensis

December 2018
Han-Wen YUAN | Jian-Ping ZHAO | Yong-Bei LIU | Yi-Xing QIU | Qing-Ling XIE | Ming-Jiao LI | Ikhlas A. KHAN | Wei WANGb

Aquilaria sinensis (Thymelaeaceae) is widely cultivated in southern China for its significant medicinal usage. The resinous wood, the most used part of the plant as traditional Chinese medicine (TCM),...

Establishing a Quality Control System of Hedyotis corymbosa

December 2018
Yan LIN | Hong-Quan LI | Bo-Hou XIA | Zhi-Min ZHANG | Ya-Mei LI | Xiao-Qing ZHANG | Ping WU | Li-Mei LIN | Duan-Fang LIAO

ObjectiveHedyotis corymbosa (Shui Xian Cao, 水线草, HC) is the main antitumor medicine in China and other southeast Asian countries. A comprehensive quality control system of HC was established in this...

Combinative Approaches of Chemistry, Pharmacology and Toxicology for the Optimal Pharmaceutical Preparation of an Anti-arthritic Chinese Medicine Formulation QFJBT

December 2018
Ting ZHANG | Huang-He YU | Ye LIN | Xin LI | Ling TAN | Hou-Pan SONG | Qing-Hua PENG | Wei WANG | Liang LIU | Cong CHEN | Xiong CAI

ObjectiveQing Fu Juan Bi Tang (QFJBT) is an anti-arthritic Chinese medicine formula consisting of five herbs: Aconiti Lateralis Radix Praeparata (Fu Zi, 附子), Sinomenii Caulis (Qing Feng Teng, 青风藤),...

Effects of Pachyman in Combination with Vinorelbine and Cisplatin on Tumor Growth and the Expression of EGFR and K-ras in Mice with Lung Cancer

December 2018
Ke WEI | Jia-Hao ZHOU | Yong-Chao CHEN | Jia-Ming TIAN | Meng-Jin SUN | Xin-Wen DAI | Bai-Hui LI | Ling LI | Fang-Liang ZHOU | Yi NING | Jue HU | Qin XIANG | Bo ZHANG | Fang-Guo LU

Objective To examine the effects of pachyman in combination with vinorelbine and cisplatin on tumor growth and the expression of epidermal growth factor receptor (EGFR) and K-ras in a mouse model of...

Effect of the Fu Zheng Method Applied by Hong-Feng CHEN on the Quality of Life in TNBC Patients and Empirical Research Based on Data Mining

December 2018
Yu-Zhu ZHANG | Yue ZHOU | Bai-Ling SHI | Hong-Feng CHEN | Li-Juan CHE

Objective To preliminarily evaluate the efficacy of the Fu Zheng method (supporting resistance against pathogenic factors) applied by Professor Hong-Feng CHEN in improving the quality of life in patients...

Quantitative Comparison of Bile Acid Distribution and Intestinal Transport from Native Cow-bezoar and Artificial and in vitro Cultured Substitutes using Caco-2 Cell Monolayer Model

December 2018
Ying CHEN | Xiao-Ru HU | Xian-Long CHENG | Shuang-Cheng MA | Qing-Sen RAN | Qing YANG | Wei-Jie QIANG | Zhong DAI | Xiao-Xin ZHU

Objective This study was conducted to examine the absorption and translocation of conjugated bile acids (BAs) in Calculus bovis and its substitutes to detect differences in these materials....

Clinical Efficacy and Therapeutic Mechanisms of Traditional Chinese Medicine for Neuroprotection and Neurogenesis in Stroke Treatment

September 2018
Jian-Gang SHEN

Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional...

A Review of Triterpenoids and Their Pharmacological Activities from Genus Kadsura

September 2018
Yong-Bei LIU | Yu-Pei YANG | Han-Wen YUAN | Ming-Jiao LI | Yi-Xing QIU | Muhammad Iqbal CHOUDHARY | Wei WANG

Plants in genus Kadsura, belong to the Schisandraceae family including genus Schisandra and genus Kadsura, revealed folk efficacy and medicinal application in the treatment of rheumatoid arthritis and...

Effects of Shuang Dan Ming Mu Capsule on Expression of VEGF-a, VEGF-b, VEGF-c and the VEGF receptor, Flk-1, in Diabetic Retinopathy Rats

September 2018
Jun PENG | Kun PAN | Zheng-Rong LIU | Yu-Hui QIN | Qing-Hua PENG

Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a, VEGF-b, VEGF-c and the VEGF receptor, Flk-1, were examined in a diabetic retinopathy rats model....

Differentially Expressed Proteins in Rat Hippocampus after Chronic Immobilization Stress and Intervention Using Xiao Yao San Decoction

September 2018
Mei-Jing KOU | Zhe XUE | Yan-Yun LIU | Yue-Yun LIU | Yan LIU | Jia-Xu CHEN

Objective To identify differentially expressed proteins in the hippocampus of rats after chronic immobilization stress (CIS) using a proteomics approach, and to study the effect of the Xiao Yao San...

Chemometrics-aided Metabolic Fingerprint Method Applied in Bladder Cancer Stages Differentiating

September 2018
You QIN | Lin CHEN | Jian-Hua HUANG | Shui-Han ZHANG | Zuo-Wei XIAO

Objective To establish early detection and diagnosis for bladder cancer....

Optimization of Ultrasound-assisted Enzymatic Polysaccharide Extraction from Turpiniae Folium Based on Response Surface Methodology

September 2018
Ling-Jia ZHAO | Bo-Hou XIA | Li-Mei LIN | Su-Hui XIONG | Jie TANG | Duan-Fang LIAO

Objective To optimize the extraction procedure and obtain the maximum total polysaccharide yield from Turpiniae Folium....

Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

September 2018
Run-Nan LIU | Yu TANG | Ping-An LIU | Wen-Long LIU | Qi-Meng FAN | Si-Yang CHEN | Peng HE | Hai-Ying LI | Fu-Yuan HE | Kai-Wen DENG

Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic...

Recommended Medicinal Plants as Source of Natural Products: A Review

June 2018
Henry Ivanz A. Boy | Alfred Joshua H. Rutilla | Kimbberly A. Santos | Allister Matthew T. Ty | Alicia I. Yu | Tooba Mahboob | Jitbanjong Tangpoong | Veeranoot Nissapatorn

Natural product is one of the sources of drugs in pharmaceutical industry, and one of the notable origin of natural product is the medicinal plants. Medicinal plants tend to cure some certain diseases...

Correlation Between Helicobacter pylori Infection and Tongue Manifestations: A Meta-analysis

June 2018
Bo-Nan HOU | Yi-Di ZENG | Hao LIANG | Rui LIU | Xiao-Qing ZHOU | Lin ZHANG | Qing-Hua PENG

Objective To analyze the relationship between Helicobacter pylori (H. pylori) infection and the manifestations of the tongue....

Lonicerae Flos: A Review of Chemical Constituents and Biological Activities

June 2018
Yan-Ran TANG | Ting ZENG | Salman zafar | Han-Wen YUAN | Bin LI | Cai-Yun PENG | Si-Cheng WANG | Yu-Qing JIAN | Yan QIN | Muhammad Iqbal Choudhary | Wei WANG

Lonicerae flos, a widely used traditional Chinese medicine (TCM), has been used for several thousand years in China. As a famous traditional Chinese herbal medicine, it was used as heat-clearing drug...

Design of a WeChat Learning Platform for Syndrome Differentiation

June 2018
Wen-Xiang Deng | Jian-Ping Zhu | Ying-Jiao Liu | Yi-Ge Zhang | Hui-Yong Huang | Wen-An Zhang

Objective To design a WeChat mini program called Chinese Syndrome Differentiation Learning Platform (CSDLP) on smartphone to improve health literacy....

Effect of Flos Buddlejae Granules on Apoptosis Factors Bax, Bcl-2, Fas and FasL in Lacrimal Gland Cells of Castrated Male Rabbits

June 2018
Yun Ou-Yang | Jun Peng | Han-Yu Tan | Wen-Juan Li | Quan-Long Wu | Qing-Hua Peng

Objective To observe the effect of different concentration Flos Buddlejae (Mi Meng Hua, 密 蒙 花) granules on apoptosis factors of lacrimal gland cells of castrated male rabbits, and study the treatment...

Constitution Identification System for Traditional Chinese Medicine (TCM) Based on Correlation Between TCM Constitution and Physical Examination Indices

June 2018
Yue Luo | Bing Lin | Chuan-Biao Wen | Jie-Lin He

Objective Identification of one’s constitution based on a combination of features and back propagation neural network theory is needed in modern medicine and traditional Chinese medicine (TCM). We describe...

Long Dan Xie Gan Formula Granule Promotes Pro-Inflammatory Cytokine Expression in Female Guinea Pigs with Recurrent Genital Herpes

June 2018
Lin KUANG | En-Hui HUANG | Qing-Hu HE | Shao-Wu CHENG | Xiao-Dan LIU

Objective To explore the effects of Long Dan Xie Gan formula granule (LDXGFG) on regulation of pro-inflammatory cytokines in female guinea pigs with recurrent genital herpes (herpes simplex virus 2,...

Ability of Tong Luo Jiu Nao Oral Solution to Improve Cognitive and Gait Deficits in a Rat Model of Focal Cerebral Ischemia

March 2018
Si-Di Li | Yi-Hua Sheng | Xin-Min Liu | Zu-Guang Ye

Objective To investigate the ability of Tong Luo Jiu Nao (TLJN) Oral Solution to improve cognitive and gait deficits in a rat model of focal cerebral ischemia....

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

March 2018
Wei-Jie Qiang | Ying Chen | Fu-Yuan He | Mei-Feng Xiao | Wei-Yan Cai | Yi-Fei Dai | Qing Yang | Yu-Jie Li | Xiao-Gang Weng | Qi Li | Ya-Jie Wang | Xiao-Xin Zhu

Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology....


March 2018
Shi-Zhen Zhong

Digital Chinese Medicine Research: an Overview

March 2018
Hui-Yong Huang | Jun-Feng Yan | Zhi-Xi Hu

Digital Chinese medicine (DCM) is an emerging interdisciplinary field developed from traditional Chinese medicine (TCM) and information science. In this article, we consider the significance and propose...

Chinese Medicine in the Management of New and Emerging Infectious Diseases

March 2018
Viroj Wiwanitkit

Emerging infectious diseases are an important problem in medicine, and many continue to pose a global threat. However, the management of new and emerging infections is usually difficult due to a lack...

Abstraction of Data Elements of Clinical Symptoms in Chinese Medicine

March 2018
Xiao-Xia Xiao | Jun-Feng Yan | Dong-Bo Liu | Hao Liang | Yin-Yin Peng | Man Li | Xiao-Qing Zhou

This report analyzes the existing problems in terminology referring to clinical symptoms of traditional Chinese medicine (TCM) from the viewpoint of data sharing and elaborates the necessity of establishing...

Optimization of GERD Therapeutic Regimen Based on ANN and Realization of MATLAB

March 2018
Wei-Wu Wang | Rui-Qing Ni | Fang-Yan Yu | Guo-Feng Lou | Cai-Dan Zhao

Objective To optimize therapeutic regimens for gastro-esophageal reflux disease (GERD), artificial neural networks (ANNs) are used to simulate and set up an intelligent traditional Chinese medicine...

Conducting a Correlation Model Between TCM Constitution and Physical Examination Index Based on BPNN Algorithm

March 2018
Yue Luo | Bing Lin | Chuan-Biao Wen | Mao Luo

This paper studies the correlation between Traditional Chinese Medicine (TCM) Constitution discrimination and physical examination index based on BPNN algorithm. 253 cases of routine urine test were...

Ophthalmic Syndrome Differentiation System and Digital Chinese Medicine

March 2018
Peng-Fei Jiang | Jun Peng | Ya-Sha Zhou | Yi-Chen Li | Qing-Hua Peng | Xiang-Dong Chen

In traditional Chinese medicine (TCM), ophthalmic syndrome differentiation is an ophthalmology-specific method for identifying syndromes based on the “Five Orbiculi” theory. It was devised by Professor...

Analysis of the Phytochemistry and Bioactivity of the Genus Polygonum of Polygonaceae

March 2018
Bing-Bing Shen | Yu-Pei Yang | Sumera Yasamin | Na Liang | Wei Su | Sheng-Huang Chen | Xiao-Juan Wang | Wei Wang

The main chemical constituents of the genus Polygonum (Polygonaceae) are flavonoids, quinones, phenylpropanoids, and terpenoids, which show anticancer, antitumor, anti-oxidative, anti-inflammatory,...

Establishment and Evaluation of a Rat Model of Spinal Cord Injury with the Pathopattern of Qi-Deficiency and Blood-Stasis in Traditional Chinese Medicine

March 2018
Liang Li | Feng Li | Jian Yin | Bo Pan | Qing-Ping Yu | Xiong Cai | Hui-Yong Huang | An Chen

Objective To establish a rat model of Spinal Cord Injury (SCI) with the pathopattern of Qi-deficiency and Blood-stasis (QDBS) in Traditional Chinese Medicine (TCM), and then assess its feasibility....

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