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Recent Liver Research Articles

Recently published articles from Liver Research.

WITHDRAWN: Do different bariatric surgery procedures impact hepassocin plasma levels in patients with type 2 diabetes mellitus?

Available online 6 August 2019
Wen-Chi Wu | Wei-Jei Lee | Chun Yeh | Shu-Chun Chen | Chih-Yen Chen

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause....

Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist

June 2019
Adnan Malik | Ani A. Kardashian | Kais Zakharia | Christopher L. Bowlus | James H. Tabibian

Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis...

The acidic pathway of bile acid synthesis: Not just an alternative pathway

June 2019
William M. Pandak | Genta Kakiyama

Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased....

Functions of hepatic non-parenchymal cells in alcoholic liver disease

June 2019
Won-Mook Choi | Myung-Ho Kim | Won-Il Jeong

Alcoholic liver disease (ALD) represents a wide spectrum of disease from simple steatosis to cirrhosis. Although there have been multiple attempts to treat ALD, its treatment is still based on abstinence...

Biliary endoscopy in the management of primary sclerosing cholangitis and its complications

June 2019
Brian M. Fung | James H. Tabibian

Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and/or extrahepatic bile ducts. It can affect...

Risk assessment and management of hepatitis B reactivation from direct-acting antivirals for hepatitis C

June 2019
Maureen Whitsett | David M. Feldman | Calvin Q. Pan

Although hepatitis B virus (HBV) reactivation has been reported in hepatitis C patients who received interferon therapy, rare cases of HBV reactivation occur in the context of direct-acting antiviral...

Emerging role of the orphan nuclear receptor estrogen-related receptor gamma in liver metabolic diseases

June 2019
Don-Kyu Kim | Hueng-Sik Choi

Estrogen-related receptor gamma (ERRγ) is one of three members of the ERR family and remains an orphan, as there are no known natural ligands. ERRγ is an inducible transcription factor, and its ligand-independent...

Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis

Available online 15 June 2019
Bernard Fromenty

Mitochondrial fatty acid oxidation (mtFAO) is a key metabolic pathway required for energy production in the liver, in particular during periods of fasting. One major consequence of drug-induced impairment...

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

March 2019
Eric K. Kwong | Huiping Zhou

The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders...

Alcoholic liver disease and mast cells: What's your gut got to do with it?

March 2019
Julie Ann Tolefree | Abigail Joy Garcia | Jenee Farrell | Vik Meadows | Lindsey Kennedy | Laura Hargrove | Jennifer Demieville | Nicole Francis | Julia Mirabel | Heather Francis

Alcoholic liver disease (ALD) remains one of the leading causes of liver injury and death when left untreated. The gut microbiota has been recognized as a key regulator of a number of pathologies, including...

Altered gut-liver axis in liver diseases

March 2019
Huiping Zhou | Jasmohan S. Bajaj | Grace L. Guo

The role of gut microbiota in liver disease development and treatment

March 2019
Lijun Wang | Yu-Jui Yvonne Wan

Liver cancer is the sixth most common cancer worldwide, and the third most common cause of cancer-related death. Hepatocellular carcinoma (HCC), which accounts for more than 90% of primary liver cancers,...

Role of gut microbiota in the development of non-alcoholic fatty liver disease

March 2019
Xuemei Wang | Jialin Xia | Changtao Jiang

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic steatosis in the absence of other causes, such as chronic alcohol consumption, that cause secondary hepatic...

Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation

March 2019
Yuan Li | Hong-Min Ni | Hartmut Jaeschke | Wen-Xing Ding

Overdose of acetaminophen (APAP) leads to liver injury, which is one of the most common causes of liver failure in the United States. We previously demonstrated that pharmacological activation of autophagy...

Endoplasmic reticulum stress and liver diseases

March 2019
Xiaoying Liu | Richard M. Green

Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring...

Bile acid receptors and gastrointestinal functions

March 2019
Alexander L. Ticho | Pooja Malhotra | Pradeep K. Dudeja | Ravinder K. Gill | Waddah A. Alrefai

Bile acids modulate several gastrointestinal (GI) functions including electrolyte secretion and absorption, gastric emptying, and small intestinal and colonic motility. High concentrations of bile acids...

Functional roles of gut bacteria imbalance in cholangiopathies

March 2019
Keisaku Sato | Fanyin Meng | Giammarco Fava | Shannon Glaser | Gianfranco Alpini

Cholangiopathies are caused by bile duct damage or inflammation followed by cholestasis leading to liver fibrosis. Bile duct epithelial cells, cholangiocytes, are a primary target for cholangiopathies....

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

December 2018
Yoon Kwang Lee | Jung Eun Park | Mikang Lee | James P. Hardwick

Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation...

Pregnane X receptor in drug-induced liver injury: Friend or foe?

December 2018
Amina I. Shehu | Xiaochao Ma

The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative...

Alcoholic liver disease: A current molecular and clinical perspective

December 2018
Koichiro Ohashi | Michael Pimienta | Ekihiro Seki

Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries, approximately 50%...

Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances

December 2018
Helen H. Wang | Piero Portincasa | Min Liu | Patrick Tso | David Q.-H. Wang

The terms biliary sludge and cholesterol microlithiasis (hereafter referred to as microlithiasis) were originated from different diagnostic techniques and may represent different stages of cholesterol...

Regulation of bile acid receptor activity

December 2018
Yu-Jui Yvonne Wan | Lili Sheng

Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well...

Hemobilia: Etiology, diagnosis, and treatment

December 2018
Rani Berry | James Han | Ani A. Kardashian | Nicholas F. LaRusso | James H. Tabibian

Hemobilia refers to bleeding from and/or into the biliary tract and is an uncommon but important cause of gastrointestinal hemorrhage. Reports of hemobilia date back to the 1600s, but due to its relative...

Autophagy in ischemic aged livers

September 2018
Choonghee Lee | Jae-Sung Kim

Ischemia/reperfusion (I/R) injury inevitably occurs during liver resection and transplantation. Elderly patients poorly recover from these surgeries. This reduced reparative capacity with aging is causatively...

Mitophagy in hepatocytes: Types, initiators and role in adaptive ethanol metabolism

September 2018
John J. Lemasters | Zhi Zhong

Mitophagy (mitochondrial autophagy) in hepatocytes is an essential quality control mechanism that removes for lysosomal digestion damaged, effete and superfluous mitochondria. Mitophagy has distinct...

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

September 2018
Bilon Khambu | Shengmin Yan | Nazmul Huda | Gang Liu | Xiao-Ming Yin

Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression...

Mechanisms of the autophagosome-lysosome fusion step and its relation to non-alcoholic fatty liver disease

September 2018
Hayato Hikita | Sadatsugu Sakane | Tetsuo Takehara

Macroautophagy (hereafter autophagy) is a catabolic process by which autophagosomes arising from an isolation membrane fuse with lysosomes to degrade components in the cytoplasm. Autophagosome-lysosome...

Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses

September 2018
Mohsin Khan | Hasan Imam | Aleem Siddiqui

Autophagy is a self-eating process, in which the damaged or excessed cell organelles and misfolded protein aggregates are removed from the cellular microenvironment. Autophagy is generally thought of...

Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy

September 2018
Xiaowen Ma | Clayre Parson | Wen-Xing Ding

The endoplasmic reticulum (ER) is an intracellular organelle consisting of a continuous network of membranes. In the liver, the ER is highly active in protein modification, lipid metabolism, and xenobiotic...

Tumor-suppressing effects of autophagy on hepatocellular carcinoma

September 2018
Lijun Pang | Kai Liu

Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing...

WITHDRAWN: Decoding the role of extracellular vesicles in liver diseases

Available online 29 August 2018
Fengyan Deng | Nancy Magee | Yuxia Zhang

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/<10.1016/j.livres.2017.11.003>.The duplicate article has therefore...

WITHDRAWN: IL-22 in liver inflammation, injury and repair

Available online 29 August 2018
Shi Yin | Dechun Feng

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.09.003. The duplicate article has therefore...

Emerging signals regulating liver tumor initiating cells

June 2018
Jingyu Chen | Chien-Yu Chen | Christopher Nguyen | Lulu Chen | Kangmin Lee | Bangyan L. Stiles

Tumor initiating cells (TICs) have been identified as cells that account for tumor heterogeneity. Recent studies demonstrated that genes controlling stem cell biology play key roles in maintaining TICs...

Neuroendocrine tumors with hepatic metastases: A review of evolving treatment options

June 2018
Steven D. Colquhoun

Once considered exceptionally rare, neuroendocrine tumors (NET) are increasingly common and therefore of growing relevance to both clinicians and researchers. Most patients with such tumors present...

Roles of microRNA in liver cancer

June 2018
Junyan Tao | Lili Jiang | Xin Chen

Primary liver cancer is the fifth most common cancer and the third leading cause of cancer death worldwide. MicroRNAs (miRNAs) are small non-coding RNA molecules that downregulate gene expression by...

Primary biliary cholangitis: Diagnosis and treatment

June 2018
Michael Chew | Christopher L. Bowlus

Primary biliary cholangitis (PBC) is an autoimmune disease that causes progressive destruction of the intrahepatic bile ducts. Although the pathogenesis of PBC is not completely understood, it is characterized...

Emerging roles of DJ-1 in liver diseases through regulation of oxidative stress and immune response

June 2018
Min Xu | Lili Chen | Jichang Li | Hailong Wu | Qiang Xia | Xiaoni Kong

Reactive oxygen species (ROS) and immune response play critical roles in the progression of liver diseases. DJ-1, also known as Parkinson disease 7 (Park7), is extensively expressed in cells and tissues,...

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis

June 2018
Jonathan Choiniere | Matthew Junda Lin | Li Wang | Jianguo Wu

Pyruvate dehydrogenase kinase 4 (PDK4) is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle (TCA cycle) in the mitochondria. Liver detoxifies xenobiotics and is constantly...

WITHDRAWN: Primary sclerosing cholangitis: A review and update

Available online 19 May 2018
James H. Tabibian | Christopher L. Bowlus

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.12.013. The duplicate article has therefore...

WITHDRAWN: Fibrolamellar hepatocellular carcinoma: Exploring molecular mechanisms and differentiation pathways to better understand disease outcomes and prognosis

Available online 17 May 2018
Cassandra A. Kersten | Elise N. Sloey | Eric Zhou | Ying Peng | Michael S. Torbenson | Yi Guo

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.12.011.The duplicate article has therefore...

WITHDRAWN: Cytokines and fatty liver diseases

Available online 17 May 2018
Lukas Niederreiter | Herbert Tilg

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2018.01.002. The duplicate article has therefore...

WITHDRAWN: Rodent models of fatty liver diseases

Available online 17 May 2018
Adeline Bertola

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2018.02.005.The duplicate article has therefore...

Role of sterile inflammation in fatty liver diseases

March 2018
Yonglin Chen | Muhammad Nadeem Yousaf | Wajahat Z. Mehal

Sterile inflammation is a ubiquitous response of tissues to stress and injury, and occurs to a high degree in the liver. This results in high levels of tissue damage after development of the metabolic...

Gut microbiota, fatty liver disease, and hepatocellular carcinoma

March 2018
Huikuan Chu | Brandon Williams | Bernd Schnabl

Intestinal bacteria contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Recently developed microbial profiling techniques are beginning to shed light on the nature of the changes...

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