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Recent Liver Research Articles

Recently published articles from Liver Research.

Bile acid receptors and gastrointestinal functions

Available online 14 January 2019
Alexander L. Ticho | Pooja Malhotra | Pradeep K. Dudeja | Ravinder K. Gill | Waddah A. Alrefai

Bile acids modulate several gastrointestinal (GI) functions including electrolyte secretion and absorption, gastric emptying, and small intestinal and colonic motility. High concentrations of bile acids...

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

Available online 20 December 2018
Yoon Kwang Lee | Jung Eun Park | Mikang Lee | James P. Hardwick

Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation...

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Available online 19 December 2018
Amina I. Shehu | Xiaochao Ma

The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative...

Alcoholic liver disease: A current molecular and clinical perspective

Available online 12 December 2018
Koichiro Ohashi | Michael Pimienta | Ekihiro Seki

Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries, approximately 50%...

Functional roles of gut bacteria imbalance in cholangiopathies

Available online 15 November 2018
Keisaku Sato | Fanyin Meng | Giammarco Fava | Shannon Glaser | Gianfranco Alpini

Cholangiopathies are caused by bile duct damage or inflammation followed by cholestasis leading to liver fibrosis. Bile duct epithelial cells, cholangiocytes, are a primary target for cholangiopathies....

Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances

Available online 20 October 2018
Helen H. Wang | Piero Portincasa | Min Liu | Patrick Tso | David Q.-H. Wang

The terms biliary sludge and cholesterol microlithiasis (hereafter referred to as microlithiasis) were originated from different diagnostic techniques and may represent different stages of cholesterol...

Autophagy in ischemic aged livers

September 2018
Choonghee Lee | Jae-Sung Kim

Ischemia/reperfusion (I/R) injury inevitably occurs during liver resection and transplantation. Elderly patients poorly recover from these surgeries. This reduced reparative capacity with aging is causatively...

Mitophagy in hepatocytes: Types, initiators and role in adaptive ethanol metabolism

September 2018
John J. Lemasters | Zhi Zhong

Mitophagy (mitochondrial autophagy) in hepatocytes is an essential quality control mechanism that removes for lysosomal digestion damaged, effete and superfluous mitochondria. Mitophagy has distinct...

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

September 2018
Bilon Khambu | Shengmin Yan | Nazmul Huda | Gang Liu | Xiao-Ming Yin

Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression...

Mechanisms of the autophagosome-lysosome fusion step and its relation to non-alcoholic fatty liver disease

September 2018
Hayato Hikita | Sadatsugu Sakane | Tetsuo Takehara

Macroautophagy (hereafter autophagy) is a catabolic process by which autophagosomes arising from an isolation membrane fuse with lysosomes to degrade components in the cytoplasm. Autophagosome-lysosome...

Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses

September 2018
Mohsin Khan | Hasan Imam | Aleem Siddiqui

Autophagy is a self-eating process, in which the damaged or excessed cell organelles and misfolded protein aggregates are removed from the cellular microenvironment. Autophagy is generally thought of...

Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy

September 2018
Xiaowen Ma | Clayre Parson | Wen-Xing Ding

The endoplasmic reticulum (ER) is an intracellular organelle consisting of a continuous network of membranes. In the liver, the ER is highly active in protein modification, lipid metabolism, and xenobiotic...

Tumor-suppressing effects of autophagy on hepatocellular carcinoma

September 2018
Lijun Pang | Kai Liu

Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing...

Regulation of bile acid receptor activity

Available online 23 September 2018
Yu-Jui Yvonne Wan | Lili Sheng

Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well...

Hemobilia: Etiology, diagnosis, and treatment

Available online 22 September 2018
Rani Berry | James Han | Ani A. Kardashian | Nicholas F. LaRusso | James H. Tabibian

Hemobilia refers to bleeding from and/or into the biliary tract and is an uncommon but important cause of gastrointestinal hemorrhage. Reports of hemobilia date back to the 1600s, but due to its relative...

WITHDRAWN: Decoding the role of extracellular vesicles in liver diseases

Available online 29 August 2018
Fengyan Deng | Nancy Magee | Yuxia Zhang

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/<10.1016/j.livres.2017.11.003>.The duplicate article has therefore...

WITHDRAWN: IL-22 in liver inflammation, injury and repair

Available online 29 August 2018
Shi Yin | Dechun Feng

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.09.003. The duplicate article has therefore...

Emerging signals regulating liver tumor initiating cells

June 2018
Jingyu Chen | Chien-Yu Chen | Christopher Nguyen | Lulu Chen | Kangmin Lee | Bangyan L. Stiles

Tumor initiating cells (TICs) have been identified as cells that account for tumor heterogeneity. Recent studies demonstrated that genes controlling stem cell biology play key roles in maintaining TICs...

Neuroendocrine tumors with hepatic metastases: A review of evolving treatment options

June 2018
Steven D. Colquhoun

Once considered exceptionally rare, neuroendocrine tumors (NET) are increasingly common and therefore of growing relevance to both clinicians and researchers. Most patients with such tumors present...

Roles of microRNA in liver cancer

June 2018
Junyan Tao | Lili Jiang | Xin Chen

Primary liver cancer is the fifth most common cancer and the third leading cause of cancer death worldwide. MicroRNAs (miRNAs) are small non-coding RNA molecules that downregulate gene expression by...

Primary biliary cholangitis: Diagnosis and treatment

June 2018
Michael Chew | Christopher L. Bowlus

Primary biliary cholangitis (PBC) is an autoimmune disease that causes progressive destruction of the intrahepatic bile ducts. Although the pathogenesis of PBC is not completely understood, it is characterized...

Emerging roles of DJ-1 in liver diseases through regulation of oxidative stress and immune response

June 2018
Min Xu | Lili Chen | Jichang Li | Hailong Wu | Qiang Xia | Xiaoni Kong

Reactive oxygen species (ROS) and immune response play critical roles in the progression of liver diseases. DJ-1, also known as Parkinson disease 7 (Park7), is extensively expressed in cells and tissues,...

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis

June 2018
Jonathan Choiniere | Matthew Junda Lin | Li Wang | Jianguo Wu

Pyruvate dehydrogenase kinase 4 (PDK4) is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle (TCA cycle) in the mitochondria. Liver detoxifies xenobiotics and is constantly...

WITHDRAWN: Primary sclerosing cholangitis: A review and update

Available online 19 May 2018
James H. Tabibian | Christopher L. Bowlus

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.12.013. The duplicate article has therefore...

WITHDRAWN: Fibrolamellar hepatocellular carcinoma: Exploring molecular mechanisms and differentiation pathways to better understand disease outcomes and prognosis

Available online 17 May 2018
Cassandra A. Kersten | Elise N. Sloey | Eric Zhou | Ying Peng | Michael S. Torbenson | Yi Guo

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.12.011.The duplicate article has therefore...

WITHDRAWN: Cytokines and fatty liver diseases

Available online 17 May 2018
Lukas Niederreiter | Herbert Tilg

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2018.01.002. The duplicate article has therefore...

WITHDRAWN: Rodent models of fatty liver diseases

Available online 17 May 2018
Adeline Bertola

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2018.02.005.The duplicate article has therefore...

Role of sterile inflammation in fatty liver diseases

March 2018
Yonglin Chen | Muhammad Nadeem Yousaf | Wajahat Z. Mehal

Sterile inflammation is a ubiquitous response of tissues to stress and injury, and occurs to a high degree in the liver. This results in high levels of tissue damage after development of the metabolic...

Cytokines and fatty liver diseases

March 2018
Lukas Niederreiter | Herbert Tilg

Cytokines are considered crucial players in inflammatory-associated disorders throughout the body. Fatty liver diseases such as alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD)...

Rodent models of fatty liver diseases

March 2018
Adeline Bertola

Fatty liver diseases including alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver diseases worldwide. ALD and NAFLD encompass a broad spectrum...

Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases

March 2018
Akiko Eguchi | Ariel E. Feldstein

Fatty liver diseases, non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common causes of chronic liver diseases around the world. NAFLD and ALD can progress towards...

Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis

March 2018
Kristin Hollister | Praveen Kusumanchi | Ruth Ann Ross | Kristina Chandler | AdePeju Oshodi | Laura Heathers | Sean Teagarden | Li Wang | Alexander L. Dent | Suthat Liangpunsakul

Excessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations....

Gut microbiota, fatty liver disease, and hepatocellular carcinoma

March 2018
Huikuan Chu | Brandon Williams | Bernd Schnabl

Intestinal bacteria contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Recently developed microbial profiling techniques are beginning to shed light on the nature of the changes...

The role of adipose tissue in fatty liver diseases

March 2018
Richard Parker

Fatty liver disease is almost always a consequence of obesity or alcohol abuse. In both cases significant changes to adipose tissue (AT) occur, which are remarkably similar despite their different causes....

WITHDRAWN: Nonalcoholic steatohepatitis therapies

Available online 14 March 2018
Winston Dunn

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.12.008. The duplicate article has therefore...

Therapies for non-alcoholic steatohepatitis

December 2017
Winston Dunn

Current phase 3 trials for the treatment of non-alcoholic steatohepatitis (NASH) are discussed in this review. Modalities that are based on weight loss include therapeutic lifestyle changes, pharmacological...

Fibrolamellar hepatocellular carcinoma: Exploring molecular mechanisms and differentiation pathways to better understand disease outcomes and prognosis

December 2017
Cassandra A. Kersten | Elise N. Sloey | Eric Zhou | Ying Peng | Michael S. Torbenson | Yi Guo

Fibrolamellar hepatocellular carcinoma (FLC) is a rare but aggressive liver cancer of children that occurs predominantly in teenagers without a history of liver disease. Surgical resection remains the...

O-glycosylation in liver cancer: Clinical associations and potential mechanisms

December 2017
Kung-Hao Liang | Chau-Ting Yeh

Liver cancer can be an aggressive disease, and is highly prevalent in Asia and Africa. However, its currently approved therapeutic strategies are far from satisfactory. Recent progress in genomic, proteomic...

Bile acid signaling and bariatric surgery

December 2017
Jingyan Tian | Silvia Huang | Siming Sun | Lili Ding | Eryun Zhang | Yanjun Liu | Wendong Huang

The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications. Bariatric surgical...

Targeting the gut barrier for the treatment of alcoholic liver disease

December 2017
Zhanxiang Zhou | Wei Zhong

Alcohol consumption remains one of the predominant causes of liver disease and liver-related death worldwide. Intriguingly, dysregulation of the gut barrier is a key factor promoting the pathogenesis...

Primary sclerosing cholangitis: A review and update

December 2017
James H. Tabibian | Christopher L. Bowlus

Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease of uncertain etiology characterized biochemically by cholestasis and histologically and cholangiographically by fibro-obliterative...

WITHDRAWN: Long noncoding RNAs in liver metabolism and liver disease: Current Status

Available online 26 November 2017
Yulan Zhao | Jianguo Wu | Suthat Liangpunsakul | Li Wang

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.09.001. The duplicate article has therefore...

WITHDRAWN: Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma

Available online 12 October 2017
Junxia Lei | Songlin Chen | Shuping Zhong

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.08.006. The duplicate article has therefore...

WITHDRAWN: Mesenchymal stem cells for treatment of steroid-resistant acute rejection after liver transplantation

Available online 12 October 2017
Yingcai Zhang | Shihui Li | Guoying Wang | Yanwen Peng | Qi Zhang | Hua Li | Jian Zhang | Genshu Wang | Shuhong Yi | Xiaoyong Chen | Andy Peng Xiang | Yang Yang | Guihua Chen

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.livres.2017.07.001. The duplicate article has therefore...

Hepatic progenitor cell activation in liver repair

September 2017
Adam Bria | Jorgensen Marda | Junmei Zhou | Xiaowei Sun | Qi Cao | Bryon E. Petersen | Liya Pi

The liver possesses an extraordinary ability to regenerate after injury. Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage. When replication...

Methionine adenosyltransferases in liver health and diseases

September 2017
Komal Ramani | Shelly C. Lu

Methionine adenosyltransferases (MATs) are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine (SAMe) from methionine and adenosine...

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