PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment
April 2024
Inclusion bodies (IBs) of respiratory syncytial virus (RSV) are formed by liquid-liquid phase separation (LLPS) and contain internal structures termed “IB-associated granules” (IBAGs), where anti-termination...
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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qīnghǎi Province, China
Available online 26 April 2024
Ticks are a major parasite on the Qīnghǎi-Tibet Plateau, western China, and represent an economic burden to agriculture and animal husbandry. Despite research on tick-borne pathogens that threaten humans...
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Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model
Available online 26 April 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, encodes several accessory proteins that have been shown to play crucial roles in regulating the innate...
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Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021–2022
Available online 26 April 2024
The recent concurrent emergence of H5N1, H5N6, and H5N8 avian influenza viruses (AIVs) has caused significant avian mortality globally. Since 2020, frequent human-animal interactions have been documented....
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Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication
Available online 16 April 2024
The pseudorabies virus (PRV) is identified as a double-helical DNA virus responsible for causing Aujeszky's disease, which results in considerable economic impacts globally. The enzyme tryptophanyl-tRNA...
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Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence
Available online 8 April 2024
Infectious diseases caused by arboviruses are a public health concern in Pakistan. However, the studies on data prevalence and threats posed by arboviruses are limited. This study investigated the seroprevalence...
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Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies
Available online 6 April 2024
African swine fever virus (ASFV) poses a significant threat to the global swine industry. Currently, there are no effective vaccines or treatments available to combat ASFV infection in pigs. The primary...
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Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory
Available online 29 March 2024
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with a case fatality rate of up...
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An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo
Available online 26 March 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still epidemic around the world. The manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories (BSL-3). In this study,...
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A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation
Available online 24 March 2024
•The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R−/− mice.•The infected mice exhibit hyperviremia and distinct splenohepatic lesions.•Virus replicon particle vaccine can protect all IFNα/β/γ...
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Crucial role played by CK8+ cells in mediating alveolar injury remodeling for patients with COVID-19
Available online 21 March 2024
The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after...
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Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China
Available online 20 March 2024
•SFTSV is detected in host-seeking ticks in rural–urban fringe areas in Beijing.•SFTSV RNA, IgM, and neutralizing antibodies are detected in stray cats in Beijing.•Multiple SFTSV genotypes naturally...
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Integration of HiBiT into enteroviruses: A universal tool for advancing enterovirus virology research
Available online 16 March 2024
The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding of enterovirus biology and its applications, enabling the development of effective...
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KIF5B-mediated internalization of FMDV promotes virus infection
Available online 16 March 2024
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, which is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific...
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Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication
February 2024
Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed...
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Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions
February 2024
Hepatitis E virus (HEV) infection can cause severe complications and high mortality, particularly in pregnant women, organ transplant recipients, individuals with pre-existing liver disease and immunosuppressed...
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SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants
February 2024
•Inactivated vaccine breakthrough infection with ancestral variants induced nearly undetectable nAbs against XBB variants.•Inactivated vaccine breakthrough infection with Omicron BA.1 or BA.5 evoked...
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Single-cell RNA sequencing to understand host-virus interactions
February 2024
Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution. This review summarizes the existing scRNA-seq...
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HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming
February 2024
The mortality of patients with severe pneumonia caused by H1N1 infection is closely related to viral replication and cytokine storm. However, the specific mechanisms triggering virus replication and...
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Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing
February 2024
The monkeypox virus (MPXV) has triggered a current outbreak globally. Genome sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and control. It is a significant...
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Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics
February 2024
The achievement of a functional cure for chronic hepatitis B (CHB) remains limited to a minority of patients treated with currently approved drugs. The primary objective in developing new anti-HBV drugs...
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Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release
February 2024
Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits...
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Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia
February 2024
Human endogenous retroviruses (HERVs) are remnants of retroviral infections in human germline cells from millions of years ago. Among these, ERVW-1 (also known as HERV-W-ENV, ERVWE1, or ENVW) encodes...
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Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses
February 2024
•Five broad-spectrum mAbs identified from COVID-19 convalescents and vaccinees possessed the ability to recognize spike S2 of pan-coronaviruses.•Five mAbs targeted distinct but conserved epitopes on...
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