#AI reads Urine# A urine-based point-of-care test for Factor Xa inhibitors in acute stroke management

This document focuses on a study of a urine-based point-of-care test for detecting Factor Xa inhibitors. The background is that for stroke patients who have taken direct oral anticoagulants, clinicians often struggle to make decisions because they are unsure whether there is a therapeutic level of anticoagulant effect in the patients' bodies. For example, patients with acute ischemic stroke may miss the opportunity for intravenous thrombolysis, or patients with intracerebral hemorrhage may mistakenly use anticoagulant reversal agents. The study enrolled patients with suspected acute stroke who might have taken Factor Xa inhibitors within 48 hours in the emergency department of an urban teaching hospital. Urine tests and plasma anti-Xa level tests were conducted simultaneously, and the initial treatment plan was not formulated based on the results of the urine test; instead, only how the treatment would be adjusted if the results were known was recorded. The results showed that 21 evaluable patients were finally included over one year, and all urine tests were successfully completed, with a median time of 59 minutes from emergency admission to testing. The sensitivity and specificity of the test for detecting plasma anti-Xa activity reaching the threshold of 30 ng/mL were 100% and 87.5%, respectively. Among 20 patients with ischemic stroke, 6 had negative urine test results, and clinicians would have administered intravenous thrombolysis to 4 of them if they had known the results. The conclusion points out that this urine-based point-of-care test is feasible and accurate, and may enable more stroke patients who were originally excluded from thrombolytic therapy to receive treatment. At the same time, it is mentioned that the test strips were donated by a relevant company, the authors have no conflicts of interest, and further research is needed to ensure safety and accurately calculate benefits.

J Stroke Cerebrovasc Dis. 2025 Nov 20:108500. doi: 10.1016/j.jstrokecerebrovasdis.2025.108500.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/