#AI reads Urine# Maternal oxidative stress throughout pregnancy and early childhood neurodevelopment at different stages

This is a prospective cohort study involving 1791 mother-child pairs in Wuhan. It measured the levels of three oxidative stress biomarkers (8-OHdG, 8-OHG, and HNE-MA) in the urine of mothers during the early, middle, and late stages of pregnancy. The neurodevelopment of children was assessed at 2, 3, and 6 years of age using the Bayley Scales of Infant Development - China Revision (BSID-CR), brain-derived neurotrophic factor (BDNF) testing, and the Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition (WPPSI-IV), respectively. The results showed that higher levels of oxidative stress biomarkers at various stages of pregnancy might be a risk factor for consistently suboptimal neurodevelopment in early childhood. Specifically, higher levels of HNE-MA in the late pregnancy were associated with lower mental development index in children at 2 years old and lower BDNF levels at 3 years old. Increased levels of 8-OHdG and 8-OHG in the middle pregnancy were respectively associated with a decrease in full-scale intelligence quotient in children at 6 years old. These findings provide new epidemiological data on the association between oxidative stress during pregnancy and child neurodevelopment, and indicate possible sensitive windows.

BMC Medicine (2025) 23:463 https://doi.org/10.1186/s12916-025-04297-3

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/