#AI reads Urine# Nanoamplifier Agents Transiently Rise the Metabolism of β‑Amyloid Peptide in Urine for the Early Diagnosis of Alzheimer's Disease

To address the lack of effective treatments for Alzheimer's disease (AD) and the critical need for early diagnosis—compounded by flaws in existing methods—the study developed a nanoamplifier named P6−Au. Based on 3 nm gold nanoparticles (AuNP), it is modified with kidney-targeting peptides and Aβ antibody 6E10. This nanoamplifier can specifically capture Aβ in the kidneys that would otherwise be reabsorbed into the bloodstream, preventing its reflux. In a mouse model of AD, tail vein injection of P6−Au increased urinary Aβ levels by over 20 times within 24 hours without significantly altering urinary background proteins. Consequently, the diagnosis of AD was advanced from the 9th month to the 5th month, offering a non-invasive and efficient new approach for the early detection of AD.

JACS Au. 2025 Nov 14;5(12):6169-6178. doi: 10.1021/jacsau.5c01121.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/