#AI reads Urine# Proteinuria is risk factor for abdominal aortic aneurysm
Published 27 May, 2025
This nationwide cohort study analyzed data from nearly 10 million adults who underwent health checkups in 2009, using the Korean National Health Insurance database, with follow-up through 2019 to investigate the association between proteinuria detected by urine dipstick test (UDT) and abdominal aortic aneurysm (AAA). Participants were categorized into five groups based on UDT results (negative, trace, 1+, 2+, ≥3+), with incident AAA as the primary endpoint.
Over a median follow-up of 9.3 years, AAA incidence rates increased significantly with higher proteinuria levels. After adjusting for multiple covariates, proteinuria showed a positive correlation with AAA risk, consistent across all estimated glomerular filtration rate categories. Subgroup analyses revealed a consistent positive trend between proteinuria severity and AAA risk regardless of age, sex, hypertension, diabetes, or chronic kidney disease (CKD), with a stronger association observed in CKD patients. Persistent proteinuria in follow-ups was linked to the highest AAA risk, while improved proteinuria reduced risk.
The study concludes that proteinuria, measured by UDT, is an independent risk factor for AAA and may serve as a potential marker to identify individuals at elevated AAA risk.
BMC Public Health. 2025 May 23;25(1):1897. doi: 10.1186/s12889-025-22989-6.
Youhe Gao
Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.
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