#AI reads Urine# Sex Associated Biomarker Differences in Chronic Kidney Disease Progression and Mortality

Abstract of the Full Text

This article, published in the Clinical Journal of the American Society of Nephrology, investigates the impact of gender differences on the progression and mortality of chronic kidney disease (CKD). By analyzing data from the NURTuRE-CKD cohort study, the research finds gender disparities in multiple biomarker levels among CKD patients, which are associated with renal injury, fibrosis, inflammation, and cardiovascular stress. The study reveals that male CKD patients have a higher risk of kidney failure and mortality, which is no longer significant after adjusting for biomarker differences. This suggests that gender differences may be a biological basis for the disparity in outcomes among CKD patients.

Key Highlights

• The study included 1,680 male and 1,204 female CKD patients, as well as 84 controls, from the NURTuRE-CKD cohort study.
• Gender disparities in multiple biomarker levels were observed among both male and female CKD patients.
• Male CKD patients exhibited higher levels of inflammatory and extracellular matrix deposition biomarkers.
• Female CKD patients showed higher levels of matrix turnover and degradation biomarkers.
• After adjusting for biomarker differences, the elevated risk associated with male CKD patients was no longer significant compared to females.

Clin J Am Soc Nephrol. 2026 Feb 5. doi: 10.2215/CJN.0000000979.

Youhe Gao

Statement: During the preparation of this work the author(s) used GLM-WEB / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/