#AI reads Urine# The urinary 6-sulfatoxymelatonin level in patients with central serous chorioretinopathy and its correlation with choroidal vasculature

This is a study on central serous chorioretinopathy, an eye disease. It enrolled 30 male patients and 30 healthy males as controls. Using ultra-widefield swept-source optical coherence tomography angiography, the study measured the choroidal vascular volume, choroidal vascularity index, and choroidal thickness in the fundus of both groups. Meanwhile, morning urine samples were collected from both groups for testing, and it was found that the level of 6-sulfatoxymelatonin (the main metabolite of melatonin) in the urine of patients (after normalization) was significantly lower than that of healthy individuals. Additionally, the choroidal vascular volume, choroidal vascularity index, and choroidal thickness of patients were generally larger than those of healthy individuals, with more obvious differences in the central and inner ring regions of the fundus. Furthermore, whether in patients or healthy individuals, the lower the level of this melatonin metabolite in urine, the higher the values of these three choroidal vascular parameters. For patients, the level of this metabolite in urine was also a key factor in predicting these three choroidal vascular parameters. Finally, the study concluded that melatonin secretion is reduced in patients with central serous chorioretinopathy, and this reduction may be associated with pathological changes such as choroidal vascular dilation and thickening. Insufficient melatonin secretion may be a risk factor for this eye disease, and 6-sulfatoxymelatonin in urine can serve as a marker reflecting the melatonin secretion status related to the disease.

Int Ophthalmol. 2025 Nov 13;45(1):472. doi: 10.1007/s10792-025-03838-2.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/