#AI reads Urine# Urinary titin represents an exciting biomarker for assessment of muscle health
Published 09 November, 2025
This review focuses on the urinary titin N-terminal fragment (UTF), a biomarker for assessing muscle health. It first introduces titin as the largest known protein in the human body, along with the background of UTF's discovery and its basic characteristics. Then, it elaborates on UTF's detection methods, which mostly rely on sandwich ELISA and require creatinine level correction. Subsequently, the review details the applications of UTF in various scenarios: in studies related to muscle atrophy, although some studies have shown a certain correlation between UTF and muscle catabolism, this correlation has not been fully confirmed; in exercise-induced muscle damage, UTF increases significantly after eccentric exercise and exhibits the repeated bout effect; in the field of muscle diseases, patients with various muscular dystrophies (such as Duchenne muscular dystrophy, Becker muscular dystrophy, etc.) and myopathies have elevated UTF levels, which may be used for disease diagnosis and treatment effect evaluation. Additionally, it mentions the research on UTF in athlete monitoring, supplement research, heart-related diseases, and cancer-related sarcopenia. Finally, the review points out that although UTF has demonstrated value in some fields, more research is still needed to clarify its application value in certain scenarios, and it is a promising non-invasive tool for assessing muscle health.
J Muscle Res Cell Motil. 2025 Oct 28. doi: 10.1007/s10974-025-09710-1.
Youhe Gao
Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.
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