#AI reads Urine# Urine bis(Monoacylglycerol)Phosphate and risk of freezing of gait in parkinson's disease

This study enrolled 354 patients with early Parkinson’s disease from the Parkinson’s Progression Markers Initiative, aiming to explore the association between urinary bis(monoacylglycerol) phosphate and the risk of freezing of gait. The levels of total di-22:6-bis(monoacylglycerol) phosphate and 2,2'-di-22:6-bis(monoacylglycerol) phosphate in the patients' urine were measured at baseline, and they were followed up for up to 5 years to observe the progression of freezing of gait. The cumulative incidence of freezing of gait and related risk factors were evaluated using the Kaplan-Meier method and Cox regression analysis. The results showed that at baseline, the patients who developed freezing of gait in the future had higher levels of total di-22:6-bis(monoacylglycerol) phosphate and 2,2'-di-22:6-bis(monoacylglycerol) phosphate. Multivariate Cox regression analysis indicated that urinary 2,2'-di-22:6-bis(monoacylglycerol) phosphate was an independent predictor of freezing of gait (hazard ratio 1.030; 95% confidence interval 1.010-1.051; p=0.010). In the subgroup analysis, with 6.33 ng/mg creatinine as the cutoff value, the incidence of freezing of gait in the "high-level" group was significantly higher than that in the "low-level" group. Moreover, in the "high-level" group, glucocerebrosidase gene variants independently increased the risk of freezing of gait, while in the "low-level" group, such gene variants had no significant effect on the occurrence of freezing of gait. The study demonstrated that baseline urinary 2,2'-di-22:6-bis(monoacylglycerol) phosphate can serve as a predictive biomarker for the development of freezing of gait in patients with early Parkinson’s disease, but the underlying mechanism still needs to be confirmed by further research.

Sci Rep. 2026 Jan 12. doi: 10.1038/s41598-026-35930-7.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/