#AI reads Urine# Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications.
Published 29 August, 2025
The study compared cell-free RNA (cfRNA) in urine and plasma for monitoring kidney injury and immune complications. It analyzed 297 samples from 24 hematopoietic stem cell transplant (HSCT) recipients, 46 immune checkpoint inhibitor (ICI)-treated patients (including those with and without acute kidney injury [AKI]), and 5 healthy volunteers. Significant differences were found in the molecular composition and cellular origin between urine and plasma cfRNA. Plasma cfRNA was more suitable for monitoring systemic and immune changes during HSCT, while urine cfRNA could better reflect kidney injury and etiology-related characteristics in ICI-treated patients. These findings indicate that urine cfRNA has great potential in monitoring kidney injury, especially AKI after ICI treatment.
Clin Chem. 2025 Aug 12:hvaf082. doi: 10.1093/clinchem/hvaf082.
Youhe Gao
With Doubao
Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.
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