#AI reads Urine# Urine Proteomic Signatures of Kidney Function Decline after Hospitalization

This study examined the urinary proteomic signatures associated with kidney function decline in post-hospitalization patients. It focused on 174 patients with or without acute kidney injury (AKI). By analyzing their urinary proteins at 3 months after hospitalization, 387 proteins were found to be associated with faster eGFR decline and 10 with slower eGFR decline. Most of these proteins showed differential expression during AKI, and 71% were expressed in kidney cells of AKI patients. The proteins formed 3 clusters, which were respectively associated with tubular injury, interstitial inflammation, and fibrosis in AKI. The study concluded that urinary proteins reflecting degenerative tubular injury, inflammation, and fibrosis are associated with eGFR decline in recently hospitalized patients, and it was supported by funding from NIDDK and others.

JCI Insight. 2025 Aug 12:e195577. doi: 10.1172/jci.insight.195577.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/