#AI reads Urine#Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia

This study, published in the American Journal of Hematology, investigated the predictive role of the urine albumin-to-creatinine ratio (uACR) and other clinical and modifiable risk factors for the decline in renal function in adult patients with sickle cell anemia (SCA) using two independent longitudinal cohorts: one from the United States (268 patients, median follow-up of 6 years) and the other from France (310 patients, median follow-up of 8.2 years). Through statistical analyses such as linear mixed-effects models, the study found that an elevated baseline uACR (especially when ≥ 100 mg/g creatinine) independently predicts a faster decline in the estimated glomerular filtration rate (eGFR). Smoking is also a factor associated with a rapid decline in eGFR that is present in both cohorts. In addition, age, hemoglobin level, lactate dehydrogenase concentration, and other factors showed associations with renal function decline in different cohorts. The study concluded that uACR is an important clinical tool for predicting the rapid decline in renal function in SCA patients and should be routinely monitored. Meanwhile, preventive measures such as smoking cessation help reduce the risk of chronic kidney disease progression in this high-risk population.

Am J Hematol. 2025 Dec 3. doi: 10.1002/ajh.70155.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/