#AI reads Urine#Cytological Appearances of Colorectal Adenocarcinoma Cells in Urine

This study aimed to evaluate the cytological characteristics of colorectal adenocarcinoma cells that invade the urinary system. By reviewing 30 urine cytology specimens from patients without a history of urothelial carcinoma, these specimens were diagnosed as high-grade urothelial carcinoma based on the Paris System for Reporting Urinary Cytology and supported by CDX-2 immunocytochemical testing. The results showed that colorectal adenocarcinoma cells in urine exhibit morphological diversity: they include not only typical tall columnar or vacuolated cells but also large cells resembling high-grade urothelial carcinoma and small cells with small round or crescent-shaped nuclei (mostly degenerated cells shed from the surface of well-to-moderately differentiated carcinomas). Poorly differentiated carcinomas, on the other hand, present as scattered isolated tumor cells. Since these cells are easily confused with high-grade urothelial carcinoma cells, accurate differentiation is difficult relying solely on urine cytology. Therefore, a multidisciplinary approach combining tissue biopsy, imaging examinations, and immunohistochemistry is required. Recognizing the morphological diversity of these cells is crucial for avoiding misdiagnosis and guiding clinical diagnosis and treatment.

Cytopathology. 2025 Dec 9. doi: 10.1111/cyt.70042.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/