#AI reads Urine#Identifying immunodominant proteins in mouse urine

This study aimed to identify the immunodominant proteins in mouse urine that are likely to trigger human allergies. First, it clarified that the core of mouse allergens is major urinary proteins (MUPs), which are divided into central MUPs (such as MUP7) and peripheral MUPs (such as MUP4 and MUP20). It also pointed out that most commercial mouse allergen extracts are made from mouse pelts, containing albumin and peripheral MUPs but lacking central MUPs, even though mouse urine is the main source of mouse allergens in the environment. Subsequently, the researchers produced relevant recombinant MUPs using bacteria and conducted inhibition experiments with sera from 17 individuals allergic to mice (containing specific IgE) and sera from healthy people as control samples. The results showed that mouse albumin and IgG do not play a key role in致敏 (allergen-induced reactions). Central MUPs, especially MUP7, were far more effective at inhibiting IgE binding than peripheral MUPs, with differences reaching up to 4 orders of magnitude in some cases. Finally, the study proposed that commercial extracts may be inadequate for allergy diagnosis and treatment due to the lack of central MUPs caused by inappropriate source material selection. It also planned to develop MUP profiling tools to facilitate the development of safer and more effective related products.

J Allergy Clin Immunol. 2025 Oct 30:S0091-6749(25)01025-5. doi: 10.1016/j.jaci.2025.09.026.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/